Breath of fresh air: new MRI could spot lung rejection before It's too late

NCT ID NCT07046910

Recruiting now Diagnosis Sponsor: University of Virginia Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a special MRI using inhaled xenon gas can detect early signs of rejection in lung transplant patients. Researchers will compare MRI images with lung tissue samples and breathing tests in 60 participants. The goal is to find a safer, non-invasive way to diagnose rejection early and prevent long-term graft failure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hyperpolarized Xenon-129 gas (inhaled contrast agent for MRI)
What this could lead to: If successful, this MRI method could allow doctors to detect lung transplant rejection earlier and more accurately, potentially improving treatment and survival.
What could go wrong: This is a small, early-phase study (60 participants) focused on diagnosis, not treatment. The MRI technique may not prove reliable enough for routine use, and results may not apply to all transplant patients.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG TRANSPLANT REJECTION

Contacts and locations

Locations

University of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States

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