Breathing in a special gas reveals hidden lung damage in transplant patients

NCT ID NCT04941573

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study used a special MRI technique with a harmless gas called hyperpolarized xenon-129 to take detailed pictures of lung function in people who had a lung transplant. The goal was to see if this scan could detect early signs of chronic lung allograft dysfunction (CLAD), a common complication after transplant. Researchers compared transplant patients, healthy volunteers, and people with COPD to understand how the gas moves through the lungs and where problems might be.

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Conditions

The condition(s) this trial relates to.

bronchiolitis obliterans syndrome chronic obstructive pulmonary disease transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States