Ketamine combo may halt prolonged seizures faster
NCT ID NCT06907173
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether adding ketamine to the standard drug levetiracetam stops prolonged seizures (status epilepticus) more effectively than levetiracetam alone. About 770 people aged 1 and older who are still seizing after initial treatment will receive either the combination or standard care. The main goal is to see if seizures stop within 15 minutes and stay stopped for an hour.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ketamine (added to levetiracetam)
What this could lead to
If successful, this could provide a faster, more effective way to stop prolonged seizures in the emergency room.
What could go wrong
This is an early-phase trial, so results may not confirm benefit. Ketamine can cause side effects like hallucinations or changes in blood pressure.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Arthur M. Blank Hospital
RECRUITINGAtlanta, Georgia, 30329, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Banner University Medical Center - Tucson Campus
RECRUITINGTucson, Arizona, 85724, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital Los Angeles
NOT_YET_RECRUITINGLos Angeles, California, 90027, United States
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Children's Hospital of Wisconsin
NOT_YET_RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Children's Medical Center Dallas
NOT_YET_RECRUITINGDallas, Texas, 75235, United States
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Children's National Medical Center
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Christiana Hospital
NOT_YET_RECRUITINGNewark, Delaware, 19718, United States
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Comer Children's Hospital
NOT_YET_RECRUITINGChicago, Illinois, 60637, United States
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Detroit Receiving Hospital
NOT_YET_RECRUITINGDetroit, Michigan, 48201, United States
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Duke Regional Hospital
NOT_YET_RECRUITINGDurham, North Carolina, 27710, United States
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Duke University Hospital
NOT_YET_RECRUITINGDurham, North Carolina, 27710, United States
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Froedtert Hospital
NOT_YET_RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Grady Memorial Hospital
RECRUITINGAtlanta, Georgia, 30303, United States
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Harborview Medical Center
RECRUITINGSeattle, Washington, 98104, United States
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Hennepin County Medical Center
NOT_YET_RECRUITINGMinneapolis, Minnesota, 55415, United States
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Henry Ford Hospital
NOT_YET_RECRUITINGDetroit, Michigan, 48202, United States
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Hospital of the University of Pennsylvania
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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IU Health Methodist Hospital
NOT_YET_RECRUITINGIndianapolis, Indiana, 46202, United States
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Jefferson Einstein Philadelphia Hospital
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19141, United States
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Massachusetts General Hospital
NOT_YET_RECRUITINGBoston, Massachusetts, 02114, United States
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Memorial Hermann Texas Medical Center
RECRUITINGHouston, Texas, 77030, United States
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
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Nemours Children's Hospital
NOT_YET_RECRUITINGWilmington, Delaware, 19803, United States
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Northwestern Memorial Hospital
NOT_YET_RECRUITINGChicago, Illinois, 60611, United States
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OSU Wexner Medical Center
NOT_YET_RECRUITINGColumbus, Ohio, 43210, United States
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Oregon Health & Science University Hospital
RECRUITINGPortland, Oregon, 97239, United States
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Orlando Regional Medical Center
NOT_YET_RECRUITINGOrlando, Florida, 32806, United States
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Penn Presbyterian Medical Center
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Primary Children's Hospital
NOT_YET_RECRUITINGSalt Lake City, Utah, 84108, United States
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Reading Hospital
RECRUITINGWest Reading, Pennsylvania, 19611, United States
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Riley Hospital for Children
NOT_YET_RECRUITINGIndianapolis, Indiana, 46202, United States
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Ronald Reagan UCLA Medical Center
NOT_YET_RECRUITINGLos Angeles, California, 90024, United States
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SUNY Upstate Medical University
NOT_YET_RECRUITINGSyracuse, New York, 13210, United States
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San Francisco General Hospital
NOT_YET_RECRUITINGSan Francisco, California, 94143, United States
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Sinai-Grace Hospital
NOT_YET_RECRUITINGDetroit, Michigan, 48201, United States
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Stanford University Medical Center
NOT_YET_RECRUITINGPalo Alto, California, 94304, United States
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Temple University Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
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UC Davis Medical Center
RECRUITINGSacramento, California, 95817, United States
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UCSF Medical Center
NOT_YET_RECRUITINGSan Francisco, California, 94143, United States
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UPMC Children's Hospital of Pittsburgh
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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UPMC Presbyterian Hospital
NOT_YET_RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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University of Chicago Medical Center
NOT_YET_RECRUITINGChicago, Illinois, 60637, United States
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University of Cincinnati Medical Center
NOT_YET_RECRUITINGCincinnati, Ohio, 45267, United States
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University of Iowa Medical Center
NOT_YET_RECRUITINGIowa City, Iowa, 52242, United States
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University of Maryland Medical Center
NOT_YET_RECRUITINGBaltimore, Maryland, 21201, United States
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University of Michigan University Hospital
RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Minnesota Masonic Children's Hospital
NOT_YET_RECRUITINGMinneapolis, Minnesota, 55414, United States
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University of Minnesota Medical Center
NOT_YET_RECRUITINGMinneapolis, Minnesota, 55455, United States
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University of Utah Healthcare
NOT_YET_RECRUITINGSalt Lake City, Utah, 84112, United States
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University of Virginia Medical Center
RECRUITINGCharlottesville, Virginia, 22908, United States
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VCU Medical Center
NOT_YET_RECRUITINGRichmond, Virginia, 23298, United States
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Yale New Haven Hospital
RECRUITINGNew Haven, Connecticut, 06519, United States
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