Ketamine combo may halt prolonged seizures faster

NCT ID NCT06907173

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether adding ketamine to the standard drug levetiracetam stops prolonged seizures (status epilepticus) more effectively than levetiracetam alone. About 770 people aged 1 and older who are still seizing after initial treatment will receive either the combination or standard care. The main goal is to see if seizures stop within 15 minutes and stay stopped for an hour.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Ketamine (added to levetiracetam)

What this could lead to

If successful, this could provide a faster, more effective way to stop prolonged seizures in the emergency room.

What could go wrong

This is an early-phase trial, so results may not confirm benefit. Ketamine can cause side effects like hallucinations or changes in blood pressure.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Status Epilepticus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Arthur M. Blank Hospital

    RECRUITING

    Atlanta, Georgia, 30329, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Banner University Medical Center - Tucson Campus

    RECRUITING

    Tucson, Arizona, 85724, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Children's Hospital Los Angeles

    NOT_YET_RECRUITING

    Los Angeles, California, 90027, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Children's Hospital of Wisconsin

    NOT_YET_RECRUITING

    Milwaukee, Wisconsin, 53226, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Children's Medical Center Dallas

    NOT_YET_RECRUITING

    Dallas, Texas, 75235, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Children's National Medical Center

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Christiana Hospital

    NOT_YET_RECRUITING

    Newark, Delaware, 19718, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Comer Children's Hospital

    NOT_YET_RECRUITING

    Chicago, Illinois, 60637, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Detroit Receiving Hospital

    NOT_YET_RECRUITING

    Detroit, Michigan, 48201, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Duke Regional Hospital

    NOT_YET_RECRUITING

    Durham, North Carolina, 27710, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Duke University Hospital

    NOT_YET_RECRUITING

    Durham, North Carolina, 27710, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Froedtert Hospital

    NOT_YET_RECRUITING

    Milwaukee, Wisconsin, 53226, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Grady Memorial Hospital

    RECRUITING

    Atlanta, Georgia, 30303, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Harborview Medical Center

    RECRUITING

    Seattle, Washington, 98104, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Hennepin County Medical Center

    NOT_YET_RECRUITING

    Minneapolis, Minnesota, 55415, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Henry Ford Hospital

    NOT_YET_RECRUITING

    Detroit, Michigan, 48202, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Hospital of the University of Pennsylvania

    NOT_YET_RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • IU Health Methodist Hospital

    NOT_YET_RECRUITING

    Indianapolis, Indiana, 46202, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Jefferson Einstein Philadelphia Hospital

    NOT_YET_RECRUITING

    Philadelphia, Pennsylvania, 19141, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Massachusetts General Hospital

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02114, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Memorial Hermann Texas Medical Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Nationwide Children's Hospital

    RECRUITING

    Columbus, Ohio, 43205, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Nemours Children's Hospital

    NOT_YET_RECRUITING

    Wilmington, Delaware, 19803, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Northwestern Memorial Hospital

    NOT_YET_RECRUITING

    Chicago, Illinois, 60611, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • OSU Wexner Medical Center

    NOT_YET_RECRUITING

    Columbus, Ohio, 43210, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Oregon Health & Science University Hospital

    RECRUITING

    Portland, Oregon, 97239, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Orlando Regional Medical Center

    NOT_YET_RECRUITING

    Orlando, Florida, 32806, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Penn Presbyterian Medical Center

    NOT_YET_RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Primary Children's Hospital

    NOT_YET_RECRUITING

    Salt Lake City, Utah, 84108, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Reading Hospital

    RECRUITING

    West Reading, Pennsylvania, 19611, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Riley Hospital for Children

    NOT_YET_RECRUITING

    Indianapolis, Indiana, 46202, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Ronald Reagan UCLA Medical Center

    NOT_YET_RECRUITING

    Los Angeles, California, 90024, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • SUNY Upstate Medical University

    NOT_YET_RECRUITING

    Syracuse, New York, 13210, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • San Francisco General Hospital

    NOT_YET_RECRUITING

    San Francisco, California, 94143, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Sinai-Grace Hospital

    NOT_YET_RECRUITING

    Detroit, Michigan, 48201, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Stanford University Medical Center

    NOT_YET_RECRUITING

    Palo Alto, California, 94304, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Temple University Hospital

    RECRUITING

    Philadelphia, Pennsylvania, 19140, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • UC Davis Medical Center

    RECRUITING

    Sacramento, California, 95817, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • UCSF Medical Center

    NOT_YET_RECRUITING

    San Francisco, California, 94143, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • UPMC Children's Hospital of Pittsburgh

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • UPMC Presbyterian Hospital

    NOT_YET_RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Chicago Medical Center

    NOT_YET_RECRUITING

    Chicago, Illinois, 60637, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Cincinnati Medical Center

    NOT_YET_RECRUITING

    Cincinnati, Ohio, 45267, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Iowa Medical Center

    NOT_YET_RECRUITING

    Iowa City, Iowa, 52242, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Maryland Medical Center

    NOT_YET_RECRUITING

    Baltimore, Maryland, 21201, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Michigan University Hospital

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Minnesota Masonic Children's Hospital

    NOT_YET_RECRUITING

    Minneapolis, Minnesota, 55414, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Minnesota Medical Center

    NOT_YET_RECRUITING

    Minneapolis, Minnesota, 55455, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Utah Healthcare

    NOT_YET_RECRUITING

    Salt Lake City, Utah, 84112, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Virginia Medical Center

    RECRUITING

    Charlottesville, Virginia, 22908, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • VCU Medical Center

    NOT_YET_RECRUITING

    Richmond, Virginia, 23298, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Yale New Haven Hospital

    RECRUITING

    New Haven, Connecticut, 06519, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact