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Brain rescue: dual drug attack on Post-Arrest seizures shows promise

NCT ID NCT05756621

Completed Disease control Sponsor: University of Milano Bicocca Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study investigates whether combining two drugs that block brain-damaging overactivity—ketamine and perampanel—can stop super-refractory status epilepticus in people who remain in a coma after cardiac arrest. Researchers will compare outcomes in 84 patients who received this dual therapy versus those who got other treatments. The goal is to see if this approach can safely resolve seizures and improve neurological recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a combination of ketamine (given intravenously) and perampanel (given orally via tube)
What this could lead to
If effective, this dual therapy could offer a new treatment option for a severe, hard-to-control seizure condition after cardiac arrest, potentially improving survival and neurological recovery.
What could go wrong
This is a retrospective study, not a randomized trial, so results may be influenced by bias. The sample is small (84 patients), and the therapy may not work for everyone or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiac arrest Status Epilepticus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC ARREST STATUS EPILEPTICUS

Contacts and locations

Locations

  • AOU Careggi

    Florence, FI, Italy

  • ASST Spedali Civili Brescia

    Brescia, BS, Italy

  • Azienda Ospedaliero-Universitaria Integrata di Verona

    Verona, VR, Italy

  • Azienda Ospedaliero-Universitaria di Modena

    Modena, MO, Italy

  • Azienda Ospedaliero-Universitaria di Parma

    Parma, PR, Italy

  • Fondazione IRCCS San Gerardo dei Tintori Monza

    Monza, MB, 20900, Italy

  • Ospedale Centrale di Bolzano

    Bolzano, BZ, Italy

  • Ospedale G. Brotzu

    Cagliari, CA, Italy

  • Ospedale M. Bufalini

    Cesena, FC, Italy

  • Ospedale Santa Chiara Trento

    Trento, TN, Italy

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