Seizure drug may shield the brain after cardiac arrest — a trial puts it to the test
NCT ID NCT06401707
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
After a cardiac arrest, many survivors develop seizures that can worsen brain injury. This trial tests whether giving the drug perampanel soon after resuscitation can prevent those seizures. About 52 adults who are comatose after a cardiac arrest will receive either perampanel or a placebo for five days. The study will check if the drug is safe and feasible to use in this setting, and whether it reduces the number of seizures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- perampanel (also known as Fycompa), a drug that blocks AMPA glutamate receptors in the brain
- What this could lead to
- If it works, this could point toward a way to prevent brain-damaging seizures after cardiac arrest, potentially improving survival and recovery.
- What could go wrong
- This is a small early-stage trial focused on safety and feasibility, so it is too soon to know if perampanel truly prevents seizures or improves outcomes. The drug may also cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Zuckerberg San Francisco General Hospital
RECRUITINGSan Francisco, California, 94110, United States
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