Cardiac arrest

This trial tests whether an adapted CPR bundle can increase the chance of restarting the heart in adults who suffer cardiac arrest outside a hospital. Participants are randomly assigned to receive either standard advanced life support or a modified approach that includes mechanic…

This trial asks whether cooling the body to 33-34°C after a cardiac arrest treated with ECMO improves survival and brain function compared to keeping a normal temperature. It includes adults aged 18-75 who had an out-of-hospital cardiac arrest with certain heart rhythms. Particip…

This study tests whether moving cardiac arrest survivors to a specialized hospital improves their recovery. About 1,600 adults who were revived after an out-of-hospital cardiac arrest will be randomly assigned to either stay at the nearest hospital or be transferred to a specialt…

This study tests whether placing a balloon in the main artery (aorta) during CPR helps restart the heart more often than standard CPR alone. The balloon is inserted through the leg and inflated to block blood flow below the chest, potentially sending more blood to the heart and b…

After a cardiac arrest, some patients develop seizures that do not respond to standard treatment. This trial tests whether putting the brain into a deeper state of electrical silence — called burst suppression — can stop those seizures better than the usual approach of only suppr…

This trial tests whether using two defibrillators in rapid succession, rather than one, can improve survival in people whose hearts stop outside a hospital. The procedure, called double sequential external defibrillation (DSED), is normally tried only after several failed attempt…

This study tests different lengths of body cooling in children who remain unconscious after a cardiac arrest outside the hospital. The goal is to see if longer cooling helps protect the brain and improve recovery. The trial will enroll 900 children and follow them for one year.

This study tests whether repeatedly inflating and deflating a blood pressure cuff on a leg can reduce brain damage in people who survive a cardiac arrest outside the hospital. The procedure, called remote ischemic post-conditioning (RIPOST), is started within 4 hours after the he…

This trial compares two treatments for white spot lesions—early cavities that appear as milky-white marks on front teeth after braces. One treatment uses a special paste (MI Paste Plus) combined with etching, while the other uses a resin infiltration technique (Icon). The study i…

This trial tests whether a special alert system called ICU Beacon can help doctors in intensive care units detect early signs of organ failure. The study includes about 1,962 adult ICU patients and compares units using the software plus standard care to those using standard care …

This study tests whether using special brain monitors (near-infrared light, ultrasound, and brain wave tracking) can help doctors better manage oxygen levels in the brain for people on life support after a cardiac arrest. The goal is to see if this approach increases the number o…

This study compares two types of CPR for people who have a cardiac arrest outside a hospital: hands-only CPR (chest compressions without rescue breaths) versus standard CPR (compressions plus rescue breaths). The trial will include over 3,000 adults whose cardiac arrest is witnes…

This phase 2 trial tests whether giving high-dose vitamin C and thiamine early after cardiac arrest can help patients recover from shock. About 234 adults who remain unconscious after cardiac arrest and need blood pressure support will be randomly assigned to get either standard …

This study tests whether emergency responders can safely use a special cooling vest on adults who have had a cardiac arrest and regained a pulse but remain unconscious. The vest is designed to cool the body quickly in the ambulance, which might protect the brain. The goal is to s…

This study tests a new step-by-step care plan for paramedics to use after an adult's heart is restarted following a cardiac arrest outside the hospital. The plan includes careful monitoring of oxygen, blood pressure, and fluids to prevent the heart from stopping again. About 318 …

This early-stage trial tests a single intravenous dose of a gene therapy called RP-A601 in 9 adults with a genetic heart condition (PKP2-ACM) that causes dangerous heart rhythms and heart failure. The therapy delivers a working copy of the PKP2 gene to heart cells to restore prot…

This trial tests whether a new app and device can help community first responders give better CPR during out-of-hospital cardiac arrests. The enhanced system allows two-way audio and one-way video communication with dispatchers, plus real-time feedback on chest compressions. Rese…

This study tests whether giving magnesium sulfate soon after a cardiac arrest can protect the brain from damage. Researchers will give 178 patients either magnesium or a saltwater solution within two hours of their heart restarting. The main goal is to see if the treatment is saf…

This trial tests whether using two defibrillators in sequence, instead of the standard single defibrillator, can improve survival in people whose hearts are in a shockable rhythm but don't respond to the first shock. About 916 adults with out-of-hospital cardiac arrest will be ra…

This study looks at whether low-dose beta-blockers can reduce dangerous heart rhythms in people who have survived a cardiac arrest with no clear cause. About 218 participants will receive one of several beta-blockers and be followed for up to 3 years. The goal is to see if this t…

This study tests whether giving a special life-support machine (ECMO) at the scene of a cardiac arrest helps more people survive than waiting until they reach the hospital. About 90 adults under 70 who have a witnessed heart attack and receive bystander CPR will be included. The …

This study tests whether adding a small valve (PEEP) to the breathing bag during CPR helps restart the heart and improve survival in adults whose heart stops outside a hospital. About 132 participants will be randomly assigned to receive CPR with or without PEEP. The goal is to s…

This study tests whether using a heart-lung machine (ECMO) right at the scene of a cardiac arrest can improve survival and brain function. Researchers will compare how quickly ECMO can be started on-site versus in the hospital. The trial involves 100 adults who have a witnessed c…

This study tests whether giving the heart medication amiodarone for 72 hours can reduce death and prevent life-threatening heart rhythms in critically ill patients who survived a cardiac arrest with a shockable rhythm. About 674 adults in intensive care will receive either amioda…

This study tests whether giving the heart medication amiodarone one cycle earlier than usual during cardiac arrest can improve survival. About 585 adults with a shockable heart rhythm will be enrolled. The goal is to see if this change in timing helps restore a normal heartbeat f…

This study compares a low cumulative dose of epinephrine (adrenaline) to the standard dose during resuscitation for out-of-hospital cardiac arrest. About 3,790 adults with a shockable heart rhythm will be enrolled. The goal is to see if using less epinephrine improves survival to…

This trial compares two ways to help patients breathe during a cardiac arrest in the hospital: a supraglottic airway (a tube placed in the throat) versus endotracheal intubation (a tube placed into the windpipe). About 1,060 adults who suffer cardiac arrest while hospitalized wil…

This study tests a new device called NEURESCUE, a balloon catheter inserted into the leg artery that inflates to redirect blood to the heart and brain during cardiac arrest. Researchers will compare standard CPR plus the device against CPR alone in 84 adults with witnessed cardia…

This study tests whether giving a combination of three drugs (epinephrine, vasopressin, and a steroid) during emergency treatment for out-of-hospital cardiac arrest can restart the heart and improve survival compared to the standard drug epinephrine alone. About 1,344 adults in T…

This study tests whether a group of treatments (like controlling body temperature, oxygen levels, blood pressure, and blood sugar) can improve brain function in adults who remain unconscious after a cardiac arrest. About 1,000 participants will be randomly assigned to receive eit…

This study tests a special breathing method (ventilation bundle) for children whose hearts stop beating in the hospital. The goal is to see if it helps more children survive and have better brain function. About 1,530 children who need CPR and a breathing tube will take part. The…

This study tests whether cooling the brain quickly after a cardiac arrest (using a special nasal device) and then keeping the body cool for 24 hours helps more people survive with full brain function. About 1,000 adults aged 18-79 who have a shockable heart rhythm will be randoml…

This phase 2 trial tests whether breathing a mix of argon gas and oxygen soon after a cardiac arrest can reduce brain damage. Researchers will enroll 120 comatose patients who were resuscitated from a witnessed cardiac arrest. The main goal is to see if argon lowers a brain injur…

This study tests whether starting a heart-lung machine (ECMO) at the scene of a cardiac arrest, instead of waiting until arrival at the hospital, can improve survival and brain function. Researchers will enroll 20 adults aged 18-70 who suffer a cardiac arrest that does not respon…

This study aims to develop a new clinical test to diagnose Calcium Release Deficiency Syndrome (CRDS), a rare inherited heart condition that increases the risk of sudden cardiac arrest. Researchers will use a pacing procedure to measure heart wave changes in 400 participants, inc…

This study compares two types of portable heart monitors in people who have symptoms of an irregular heartbeat (arrhythmia) but whose standard heart test was normal. About 588 participants will wear either a continuous ECG patch or use a handheld ECG device for one month. The goa…

This study evaluates a new multichannel ECG system designed to detect early signs of cardiovascular disease (CVD) in people who may have no symptoms yet. The system uses advanced algorithms to analyze electrical signals from the heart, looking for subtle abnormalities that could …

This study is testing a cloud-based artificial intelligence platform called Willem that analyzes ECG recordings to detect heart rhythm problems and abnormal patterns. Researchers will compare the AI's readings to those of board-certified cardiologists in over 5,300 high-risk card…

This study tests a new, noninvasive method to quickly determine if critically ill children need intravenous fluids. The method uses gentle abdominal pressure and a device that measures blood flow. If accurate, it could help doctors avoid giving unnecessary fluids, which can be ha…

This study tests a new CT scan method that checks for blocked heart arteries in people who survive a cardiac arrest, without needing extra medication or heart monitoring. About 30 adults who have been revived after a cardiac arrest will get this special CT scan, and the results w…

After a cardiac arrest, many survivors develop seizures that can worsen brain injury. This trial tests whether giving the drug perampanel soon after resuscitation can prevent those seizures. About 52 adults who are comatose after a cardiac arrest will receive either perampanel or…

This pilot study tests a program called Heartsight, which provides educational modules to caregivers of children who have had a cardiac arrest. The goal is to see if the program is feasible and acceptable, and whether it can reduce caregivers' uncertainty, anxiety, depression, an…

This study tests a modified imaging catheter (ViewFlex X ICE) to help doctors see heart structures during procedures for irregular heartbeats. About 500 adults who are already scheduled for a heart procedure using ultrasound will be enrolled. The goal is to see if the new cathete…

This study looks at how a child's quality of life changes after a procedure called transcatheter ablation, which treats abnormal heart rhythms. Researchers will ask 200 children aged 5 to 17 and their parents to fill out questionnaires about physical, emotional, social, and schoo…

This study tests whether a 12-week home walking program can improve daily activity and quality of life in people who have an implantable cardioverter defibrillator (ICD). Researchers will enroll 210 adults who can walk without help and have had an ICD placed to prevent sudden car…

This study tests a new therapy called AMBET (Acceptance- and Mindfulness-Based Exposure Therapy) for treating PTSD in people who survived a cardiac arrest. About 90 adults will be randomly assigned to either AMBET or a standard talk therapy (PCT) for 12 weeks. Researchers will tr…

This study tests whether a web-based program can improve quality of life for people who survived a cardiac arrest outside the hospital. The program includes educational sessions, brain games, and tips on physical activity and nutrition. Researchers will enroll 106 survivors and m…

This study tests two mind-body programs designed to reduce anxiety, depression, and emotional distress in cardiac arrest survivors and their caregivers. About 84 pairs (survivor and a family member or friend who helps them) will participate. The goal is to see if the programs are…

This study looks at how therapeutic cooling after cardiac arrest affects the body's energy expenditure and which nutrients (sugars, fats, proteins) are burned for fuel. About 40 unconscious patients will be cooled to either 33°C or 36°C and given a fixed nutrition plan. Researche…

This study observes how core body temperature changes in adults who experience cardiac arrest outside the hospital. Researchers will measure temperature using a probe inserted into the esophagus during resuscitation and transport to the hospital. They will also track environmenta…

This study looks at whether using a special heart ultrasound (called TEE) during emergencies helps doctors make better decisions and improves patient outcomes. Researchers will track 1,000 critically ill adults in the ER or ICU who receive this test as part of their care. The goa…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study follows 30,000 people in Korea who experienced cardiac arrest outside a hospital, tracking their survival and brain function for up to six months. The goal is to understand the factors that influence outcomes, which could help improve emergency care and resuscitation p…

This study collects information from trauma patients who experienced cardiac arrest due to injury. Researchers will review medical records to see how different pre-hospital treatments, like breathing tubes or medications, relate to survival. The goal is to find patterns that coul…

This study will collect ECG recordings from 600 people using the HeartBeam 3-Lead ECG recorder. The goal is to build a database of heart rhythm information for future research and regulatory use. Participants will have their ECG taken as part of routine care, and their de-identif…

This study tests whether improved telephone instructions for CPR can reduce the time without chest compressions when using an AED. About 80 volunteers will act as single rescuers in a simulated cardiac arrest. Half will get standard phone CPR guidance, and half will get enhanced …

This study tests whether a live video connection between paramedics and pediatric emergency doctors improves care for critically ill children. Paramedics will treat infant mannequins in simulated ambulance scenarios, with some getting video support and others only audio. The goal…

This study tests whether an artificial intelligence algorithm can predict survival and complications in people who have had a cardiorespiratory arrest and been revived. Researchers will analyze hospital records from 300 to 500 patients treated in intensive care units in France be…

This study tests whether advanced MRI scans that map the brain's structural and functional connections can better predict neurological recovery in coma patients after cardiac arrest than standard methods. Researchers will scan 263 adults who remain unconscious at least 72 hours a…

This study observes 50 adult organ donors to measure oxygen levels in the blood when the heart stops during a Maastricht III donation procedure. Researchers take blood samples at key moments to understand how low oxygen gets. The goal is to gather knowledge, not to test a treatme…

This observational study at Brigham and Women's Hospital will use advanced MRI scans to see if brain activity and structure can predict recovery in 50 people who are comatose after a cardiac arrest. Participants will have a special MRI during their standard scan and be followed f…

After a cardiac arrest, many patients remain comatose and are at risk of further brain injury. Doctors currently measure brain oxygen by drawing blood from the jugular vein and sending it to a lab, which takes time. This study tests a special catheter that can measure oxygen leve…

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study looks at people who had a heart attack and also developed a dangerous heart rhythm (ventricular arrhythmia) while still in the hospital. Researchers want to learn more about how these patients are treated and how many die after leaving the hospital. The study does not …

This study tests whether paramedics can safely place a small tube in the leg artery of people having a cardiac arrest outside the hospital. The tube allows continuous blood pressure monitoring, which may help doctors give the right amount of medication to keep the heart pumping. …

This study explores whether drones can deliver automated external defibrillators (AEDs) to people experiencing cardiac arrest in rural areas faster than traditional emergency responders. Researchers will compare arrival times and see if drone delivery is practical enough to test …

This study looks at how artificial intelligence (AI) can help emergency call operators quickly identify life-threatening situations like cardiac arrest, stroke, or severe breathing problems. Researchers will analyze millions of past emergency calls to train AI models to recognize…

This study looks at how much pain people feel after a cardiac arrest while they are in the intensive care unit. Researchers will track pain using special scales, even in patients who are unconscious or on a breathing machine. The goal is to understand how pain affects recovery, s…

This study looks at whether checking pupils and brain oxygen levels right before starting ECMO can help predict neurological recovery in cardiac arrest patients. Researchers will measure these in 45 adults being evaluated for ECMO, before and after the procedure. The goal is to s…

This study is testing different treatments to reduce major complications and improve survival in 600 adults who need ECMO—a machine that does the work of the heart and lungs. Researchers will compare how well these treatments work in the first 28 days. The goal is to find safer, …

This study looks at whether long-term stress, measured by cortisol levels in hair, is linked to cardiac arrest. Researchers will take a small hair sample from 136 patients who had a cardiac arrest or heart attack. The goal is to see if higher stress levels over the past three mon…

This study tests whether a mixed reality (MR) system called HEROS 4.0 can teach CPR as effectively as traditional instructor-led classes. 120 adults who haven't had CPR training in the last year will be split into two groups: one using MR and one using standard video and in-perso…

This study aims to find genetic causes of out-of-hospital cardiac arrest in people aged 18–50 in Lombardy, Italy. Researchers will analyze blood samples from 1,725 patients and also check family members for inherited heart risks. The goal is to better understand why cardiac arres…

This study watches how hospital staff give breaths during CPR to adults whose hearts stop. It will measure the rate and volume of breaths and see which levels are linked to restarting the heart and surviving 30 days. The goal is to find the best ventilation approach during CPR.

This study looks at whether combining blood tests and brain ultrasound can better predict how well someone recovers from a cardiac arrest. Researchers will enroll 50 adults and check their blood for proteins linked to inflammation and use ultrasound to measure brain blood flow an…

This study aims to improve how doctors predict the risk of sudden cardiac death or heart failure in people with inherited heart diseases. Researchers will use artificial intelligence to analyze data from 1,000 participants, including medical history, ECGs, imaging, genetic tests,…

This study follows people who survived a cardiac arrest and received ultra-rapid cooling treatment in a previous study. Researchers will check their health and survival status over 5 years through phone interviews and medical records. The goal is to understand the long-term effec…

This study is looking for proteins, metabolites, and platelet changes in the blood that could predict whether a person will survive after receiving ECPR, a machine that takes over heart and lung function during cardiac arrest. Researchers will study blood samples from 130 adults …

This study aims to uncover the molecular causes of secondary brain injury in patients who survive cardiac arrest. Researchers will analyze cerebrospinal fluid from 60 participants using advanced techniques to identify changes in genes, proteins, and other molecules. The goal is t…

This study tests whether a balloon device, called REBOA, can be safely used by emergency teams outside a hospital to improve blood flow in people whose heart has stopped (cardiac arrest). The balloon is inserted into the main artery and inflated to redirect blood to the heart and…

This study looks at why the airway sometimes closes during CPR for people who have a cardiac arrest outside the hospital. Researchers will analyze breathing data from 150 adults to see how common this closure is and whether it affects the chances of restarting the heart. The goal…

This study looks at rules doctors use to decide when to stop trying to revive someone after a cardiac arrest outside the hospital. These rules were made in Western countries, and this study checks if they work for people in Asia. Researchers will study 140,000 patients to see if …

This study tests an AI system that reads blood pressure signals during CPR to tell rescuers if they are compressing the wrong part of the chest. In about half of cardiac arrest patients, standard chest compressions accidentally press on a valve in the heart, reducing blood flow. …

This study explores using drones to quickly deliver automated external defibrillators (AEDs) to people helping someone having a cardiac arrest outside a hospital. Researchers will test the delivery process with training manikins and interview people with and without cardiac arres…

This study is a registry that will collect detailed information from 400 people who had a cardiac arrest outside of a hospital. The goal is to better understand what happens before, during, and after the event, so doctors can improve care and survival rates. Participants are foll…

This study looks at whether MRI scans can help predict serious heart events in people who have implanted heart devices like pacemakers or defibrillators. Researchers will scan 1,500 adults before they get their device and track their health for years. The goal is to see if MRI fi…

This study tests a portable MRI machine to look for brain injury in patients who have had a cardiac arrest. Researchers will scan the brain multiple times over several days to see how injuries change. The goal is to make brain imaging available at hospitals without specialized sc…

This study compares two ways of training emergency teams to handle adult cardiac arrest: training in the actual emergency room (in-situ) versus training in a separate simulation center (off-site). About 100 healthcare professionals from two hospital campuses will participate. The…

This study follows 700 patients who received ECMO after cardiac arrest to find out what predicts survival and good brain function. Researchers will also check if pre-primed ECMO machines work safely and how patients fare years later. The goal is to help doctors choose the right p…

This study tests whether a serious game (a digital learning tool) can improve critical care nurses' knowledge of targeted temperature management—a cooling treatment used after cardiac arrest. 120 nurses from adult ICUs will be split into two groups: one gets standard lectures, th…

This study looks at how the height of a hospital bed affects the quality of CPR given to children. 25 pediatric doctors will each perform chest compressions on a child-sized manikin at four different bed heights. The goal is to find the bed height that helps doctors give the best…

This study looks at a better way to predict recovery in people who remain unconscious after a cardiac arrest. Doctors often struggle to know who will wake up, which can lead to early decisions to stop life support. The study will follow 600 patients in the US, Brazil, and Italy, …

This study tests a new tool called PRECOM that uses brain wave signals to predict whether coma patients after cardiac arrest will wake up within three months. Researchers will enroll 100 adults in French ICUs and compare the tool's predictions to actual outcomes. The goal is to i…

This study tests a special rehabilitation program designed to help people who survived a sudden cardiac arrest return to work. The program includes tailored support and is compared to usual care alone. About 214 survivors will take part, and researchers will track their work stat…

This study measures how much air actually reaches the lungs when rescuers give breaths by hand during cardiac arrest. It compares two common airway devices—tracheal tubes and laryngeal mask airways—using a small flow sensor. The 30 participants are already part of a larger trial …

This study watches 250 adults who are unconscious after a cardiac arrest to see if early brain tests can predict when they will wake up. Researchers use tools like EEG and ultrasound to monitor the brain. The goal is to find reliable signs of recovery, not to test a new treatment…

This study looks at how care in the emergency room (ER) after a heart attack affects short-term survival. Researchers will review records from 6,000 adults who had a heart attack outside the hospital and were revived in the ER. The goal is to find which ER treatments and timing h…

This study looks at how frailty—a state of increased weakness—impacts the results of CPR in patients who need emergency resuscitation. Researchers will track factors like the reason for the emergency, how long CPR lasts, and what equipment is used. The goal is to better understan…

This study compares different scoring systems to predict brain damage in patients admitted to the ICU after cardiac arrest. Researchers will calculate early prognosis scores using clinical and lab values to see which system best identifies patients at risk. The goal is to help do…

This study watches how doctors and nurses perform CPR on children who have had a cardiac arrest. Researchers will check if following American Heart Association guidelines for chest compression depth, rate, and timing leads to better outcomes. Up to 7,000 children across multiple …

This study is testing a new training program that teaches doctors how to use a special ultrasound (TEE) during cardiac arrest. The program includes a lecture and hands-on practice with a simulator. Researchers are also developing an AI tool to assess how well doctors perform. The…

This study observes 128 critically ill ICU patients to see how two common sedatives—propofol and ketamine—affect the risk of severe drops in blood pressure or cardiac arrest during emergency intubation. Propofol can lower blood pressure, while ketamine may help maintain stability…

This study is for people starting a type of cancer drug called BTK inhibitors, which can sometimes cause irregular heartbeats. Researchers will implant a small heart monitor under the skin to watch for these heart rhythm problems continuously for up to 5 years. The goal is to lea…

This study will follow 10,000 people who come to a clinic in Davos, Switzerland for cardiac rehabilitation after a heart attack, surgery, or other heart problem. Researchers will collect health data, blood samples, and genetic information to understand what helps people recover b…

This study explores whether using emotional sounds—like a patient's own name spoken by a family member—can improve brain wave tests that help predict recovery in people with disorders of consciousness. Researchers will compare brain responses to familiar versus unfamiliar voices …

This study looks at 840 people in Paris whose hearts stopped and didn't restart with standard CPR. They received a special life-support machine called ECMO to keep blood flowing. Researchers will track how many survive for one year and how well their brains recover. The goal is t…

This study is testing a special heart monitor, the BIOMONITOR IV, in 300 people with heart failure who also have irregular heartbeats. The device tracks heart activity, fluid levels, and breathing patterns to see if it can predict when heart failure gets worse. Researchers hope t…

This study tests whether a clear plastic box placed over a patient's head during CPR can reduce the spread of viruses like COVID-19 to healthcare workers. Researchers will simulate cardiac arrest scenarios with 240 participants, measuring how well the box works during chest compr…