Cardiac arrest

This trial compares two treatments for white spot lesions—early cavities that appear as milky-white marks on front teeth after braces. One treatment uses a special paste (MI Paste Plus) combined with etching, while the other uses a resin infiltration technique (Icon). The study i…

This study tests whether taking a daily fiber and magnesium supplement (WellBiome) for 6-8 weeks before heart surgery can improve recovery. Researchers will compare ICU time, complications, and hospital stay between 80 patients who get the supplement or a placebo. The goal is to …

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This trial tests whether a special alert system called ICU Beacon can help doctors in intensive care units detect early signs of organ failure. The study includes about 1,962 adult ICU patients and compares units using the software plus standard care to those using standard care …

This study tests whether repeatedly inflating and deflating a blood pressure cuff on a leg can reduce brain damage in people who survive a cardiac arrest outside the hospital. The procedure, called remote ischemic post-conditioning (RIPOST), is started within 4 hours after the he…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This study tests whether using special brain monitors (near-infrared light, ultrasound, and brain wave tracking) can help doctors better manage oxygen levels in the brain for people on life support after a cardiac arrest. The goal is to see if this approach increases the number o…

This study tests different lengths of body cooling in children who remain unconscious after a cardiac arrest outside the hospital. The goal is to see if longer cooling helps protect the brain and improve recovery. The trial will enroll 900 children and follow them for one year.

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study compares two types of CPR for people who have a cardiac arrest outside a hospital: hands-only CPR (chest compressions without rescue breaths) versus standard CPR (compressions plus rescue breaths). The trial will include over 3,000 adults whose cardiac arrest is witnes…

This phase 2 trial tests whether giving high-dose vitamin C and thiamine early after cardiac arrest can help patients recover from shock. About 234 adults who remain unconscious after cardiac arrest and need blood pressure support will be randomly assigned to get either standard …

This study tests whether a special activity score, calculated from heart rate data, can help people who have completed cardiac rehab stick to exercise guidelines. About 318 participants will wear a smartwatch for 4 months and do an exercise test at the end. Researchers will compa…

This study compares two methods for closing the breastbone after open-heart surgery: rigid plate fixation (using a metal plate and screws) versus traditional wire cerclage (using stainless steel wires). The trial will enroll 250 adults at high risk for wound complications, such a…

This study tests whether text messages can help people who have finished cardiac rehab keep up healthy habits like weight management, physical activity, and taking medications. Researchers will enroll 400 people from groups often left out of heart research. The study compares dif…

This study tests whether emergency responders can safely use a special cooling vest on adults who have had a cardiac arrest and regained a pulse but remain unconscious. The vest is designed to cool the body quickly in the ambulance, which might protect the brain. The goal is to s…

This study tests a new step-by-step care plan for paramedics to use after an adult's heart is restarted following a cardiac arrest outside the hospital. The plan includes careful monitoring of oxygen, blood pressure, and fluids to prevent the heart from stopping again. About 318 …

This study tests whether placing a balloon in the main artery (aorta) during CPR helps restart the heart more often than standard CPR alone. The balloon is inserted through the leg and inflated to block blood flow below the chest, potentially sending more blood to the heart and b…

This study tests a device called Efferon LPS that filters harmful substances from the blood during and after heart surgery. The goal is to see if it can reduce the risk of multiple organ failure, a serious complication. Researchers will enroll 60 adults having heart surgery with …

This early-stage trial tests a single intravenous dose of a gene therapy called RP-A601 in 9 adults with a genetic heart condition (PKP2-ACM) that causes dangerous heart rhythms and heart failure. The therapy delivers a working copy of the PKP2 gene to heart cells to restore prot…

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This trial tests whether a new app and device can help community first responders give better CPR during out-of-hospital cardiac arrests. The enhanced system allows two-way audio and one-way video communication with dispatchers, plus real-time feedback on chest compressions. Rese…

This study tests a new method called decrement evoked potential (DeEP) mapping to guide catheter ablation for ventricular tachycardia (VT) in people with structural heart disease. VT is a fast, dangerous heart rhythm that can cause sudden cardiac arrest. The standard ablation pro…

This study tests whether giving magnesium sulfate soon after a cardiac arrest can protect the brain from damage. Researchers will give 178 patients either magnesium or a saltwater solution within two hours of their heart restarting. The main goal is to see if the treatment is saf…

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study looks at whether people at moderate risk for heart problems should continue or stop taking aspirin before a colonoscopy. About 2,500 participants will be randomly assigned to take either aspirin or a placebo for a few days around the procedure. The goal is to see which…

This study tests a noninvasive radiation treatment (SBRT) for people with ventricular tachycardia, a dangerous heart rhythm that can cause sudden death. The 12 participants have structural heart disease and have not been helped by standard treatments like drugs or catheter ablati…

This study compares a single dose of targeted radiation (SBRT) to the standard catheter ablation procedure for reducing dangerous heart rhythms in people with advanced heart disease. Sixty participants will be randomly assigned to one of the two treatments. The main goal is to se…

This trial tests whether using two defibrillators in sequence, instead of the standard single defibrillator, can improve survival in people whose hearts are in a shockable rhythm but don't respond to the first shock. About 916 adults with out-of-hospital cardiac arrest will be ra…

This study tests a program that uses an AI chatbot, health coach, and home monitoring devices to help 300 adults with heart disease, diabetes, or kidney disease manage their conditions. The goal is to see if this approach reduces hospital visits, complications, and deaths over 6 …

This study looks at whether low-dose beta-blockers can reduce dangerous heart rhythms in people who have survived a cardiac arrest with no clear cause. About 218 participants will receive one of several beta-blockers and be followed for up to 3 years. The goal is to see if this t…

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on heart health. The goal is to see if th…

This study tests whether giving a special life-support machine (ECMO) at the scene of a cardiac arrest helps more people survive than waiting until they reach the hospital. About 90 adults under 70 who have a witnessed heart attack and receive bystander CPR will be included. The …

This study tests whether adding a small valve (PEEP) to the breathing bag during CPR helps restart the heart and improve survival in adults whose heart stops outside a hospital. About 132 participants will be randomly assigned to receive CPR with or without PEEP. The goal is to s…

This study is testing whether giving air conditioners and a $100 electricity subsidy to older adults in Boston neighborhoods can reduce heat stress, heat strain, and related health problems. One hundred participants aged 55-95 who don't have AC will be randomly assigned to receiv…

This study tests whether using a heart-lung machine (ECMO) right at the scene of a cardiac arrest can improve survival and brain function. Researchers will compare how quickly ECMO can be started on-site versus in the hospital. The trial involves 100 adults who have a witnessed c…

This study tests whether giving the heart medication amiodarone for 72 hours can reduce death and prevent life-threatening heart rhythms in critically ill patients who survived a cardiac arrest with a shockable rhythm. About 674 adults in intensive care will receive either amioda…

This study tests whether giving the heart medication amiodarone one cycle earlier than usual during cardiac arrest can improve survival. About 585 adults with a shockable heart rhythm will be enrolled. The goal is to see if this change in timing helps restore a normal heartbeat f…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV. About 121 adults aged 40 and older with well-controlled HIV and at least one heart disease risk factor will receive either the drug or…

This study compares a low cumulative dose of epinephrine (adrenaline) to the standard dose during resuscitation for out-of-hospital cardiac arrest. About 3,790 adults with a shockable heart rhythm will be enrolled. The goal is to see if using less epinephrine improves survival to…

This trial compares two ways to help patients breathe during a cardiac arrest in the hospital: a supraglottic airway (a tube placed in the throat) versus endotracheal intubation (a tube placed into the windpipe). About 1,060 adults who suffer cardiac arrest while hospitalized wil…

This study tests a new device called NEURESCUE, a balloon catheter inserted into the leg artery that inflates to redirect blood to the heart and brain during cardiac arrest. Researchers will compare standard CPR plus the device against CPR alone in 84 adults with witnessed cardia…

This study tests whether giving a combination of three drugs (epinephrine, vasopressin, and a steroid) during emergency treatment for out-of-hospital cardiac arrest can restart the heart and improve survival compared to the standard drug epinephrine alone. About 1,344 adults in T…

This study tests whether a group of treatments (like controlling body temperature, oxygen levels, blood pressure, and blood sugar) can improve brain function in adults who remain unconscious after a cardiac arrest. About 1,000 participants will be randomly assigned to receive eit…

This study tests a special breathing method (ventilation bundle) for children whose hearts stop beating in the hospital. The goal is to see if it helps more children survive and have better brain function. About 1,530 children who need CPR and a breathing tube will take part. The…

This study tests whether cooling the brain quickly after a cardiac arrest (using a special nasal device) and then keeping the body cool for 24 hours helps more people survive with full brain function. About 1,000 adults aged 18-79 who have a shockable heart rhythm will be randoml…

This phase 2 trial tests whether breathing a mix of argon gas and oxygen soon after a cardiac arrest can reduce brain damage. Researchers will enroll 120 comatose patients who were resuscitated from a witnessed cardiac arrest. The main goal is to see if argon lowers a brain injur…

This study tests whether starting a heart-lung machine (ECMO) at the scene of a cardiac arrest, instead of waiting until arrival at the hospital, can improve survival and brain function. Researchers will enroll 20 adults aged 18-70 who suffer a cardiac arrest that does not respon…

This study tests a new, noninvasive method to quickly determine if critically ill children need intravenous fluids. The method uses gentle abdominal pressure and a device that measures blood flow. If accurate, it could help doctors avoid giving unnecessary fluids, which can be ha…

This study is testing a cloud-based artificial intelligence platform called Willem that analyzes ECG recordings to detect heart rhythm problems and abnormal patterns. Researchers will compare the AI's readings to those of board-certified cardiologists in over 5,300 high-risk card…

This study is testing a special mattress that can measure heart rate, breathing, temperature, and body position without touching the patient. It is designed for people with heart disease who are in the hospital. The goal is to see if this wireless system works as well as standard…

This study tests a new CT scan method that checks for blocked heart arteries in people who survive a cardiac arrest, without needing extra medication or heart monitoring. About 30 adults who have been revived after a cardiac arrest will get this special CT scan, and the results w…

This study checks if a quick, non-invasive finger test (QuantaFlo HD) can detect early signs of heart dysfunction. Researchers will compare the finger test results with standard heart ultrasound measurements in 600 adults who have risk factors like high blood pressure or diabetes…

This study is testing whether a machine learning algorithm can accurately detect heart murmurs that point to structural heart disease. Researchers will record heart sounds from 125 adults using two different digital stethoscopes and compare the algorithm's findings to standard ec…

This study compares two types of portable heart monitors in people who have symptoms of an irregular heartbeat (arrhythmia) but whose standard heart test was normal. About 588 participants will wear either a continuous ECG patch or use a handheld ECG device for one month. The goa…

This study tests a smartphone app designed to help people prepare for heart surgery through exercise, nutrition tips, and telehealth check-ins. About 40 adults awaiting surgery will either use the app or receive standard care. Researchers want to see if the app is easy to use, ac…

This study tests a 6-session program called BE-FIT that helps cardiac rehabilitation patients reduce anxiety about exercise. The program uses gradual exposure to feared sensations, prevents safety behaviors, and uses activity monitors for feedback. Researchers will enroll 146 adu…

This study tests a modified imaging catheter (ViewFlex X ICE) to help doctors see heart structures during procedures for irregular heartbeats. About 500 adults who are already scheduled for a heart procedure using ultrasound will be enrolled. The goal is to see if the new cathete…

This study looks at how a child's quality of life changes after a procedure called transcatheter ablation, which treats abnormal heart rhythms. Researchers will ask 200 children aged 5 to 17 and their parents to fill out questionnaires about physical, emotional, social, and schoo…

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients. Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program encourages simple activities like standing, walki…

This study tests whether a 12-week home walking program can improve daily activity and quality of life in people who have an implantable cardioverter defibrillator (ICD). Researchers will enroll 210 adults who can walk without help and have had an ICD placed to prevent sudden car…

This study tests a new therapy called AMBET (Acceptance- and Mindfulness-Based Exposure Therapy) for treating PTSD in people who survived a cardiac arrest. About 90 adults will be randomly assigned to either AMBET or a standard talk therapy (PCT) for 12 weeks. Researchers will tr…

This study tests whether a web-based program can improve quality of life for people who survived a cardiac arrest outside the hospital. The program includes educational sessions, brain games, and tips on physical activity and nutrition. Researchers will enroll 106 survivors and m…

This study tests whether adding a program that targets sleep and stress (called RESST) to standard cardiac rehabilitation helps heart patients recover better. About 200 adults with heart conditions who also have poor sleep or high stress will take part. Researchers will measure s…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program for women with heart disease. Sixty women aged 40-80 will attend 36 sessions over 12 weeks, with extra women-focused education. Researchers will measure attendance, completion rat…

This study tests two mind-body programs designed to reduce anxiety, depression, and emotional distress in cardiac arrest survivors and their caregivers. About 84 pairs (survivor and a family member or friend who helps them) will participate. The goal is to see if the programs are…

This study tests a program called One-Mind One-Heart that combines mindfulness and behavior change skills to help older adults with HIV reduce stress and improve heart health. The program includes text messages and covers topics like physical activity, diet, and substance use. Th…

This study tests whether a standardized, step-by-step protocol for giving blood thinner injections (low-molecular-weight heparin) can reduce bruising and pain in heart patients. About 180 patients in cardiac care units will be randomly assigned to receive injections either by the…

This registry study will enroll 200,000 high-risk cardiac patients to see how well an AI platform called Willem can detect heart problems from standard ECGs. The AI's readings will be compared to expert cardiologist diagnoses, but the AI results won't be shared with doctors, so p…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study tests whether a live video connection between paramedics and pediatric emergency doctors improves care for critically ill children. Paramedics will treat infant mannequins in simulated ambulance scenarios, with some getting video support and others only audio. The goal…

This study tests whether an artificial intelligence algorithm can predict survival and complications in people who have had a cardiorespiratory arrest and been revived. Researchers will analyze hospital records from 300 to 500 patients treated in intensive care units in France be…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This study tests whether advanced MRI scans that map the brain's structural and functional connections can better predict neurological recovery in coma patients after cardiac arrest than standard methods. Researchers will scan 263 adults who remain unconscious at least 72 hours a…

This study observes 50 adult organ donors to measure oxygen levels in the blood when the heart stops during a Maastricht III donation procedure. Researchers take blood samples at key moments to understand how low oxygen gets. The goal is to gather knowledge, not to test a treatme…

This study looks at medical records of 1,000 older heart patients in Russia to see if they were prescribed potentially harmful medications during the COVID-19 pandemic. Researchers will use a medical database to count how often these risky prescriptions happened and check for dan…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study is testing whether simple nutritional checks before heart surgery can predict how well patients recover. Researchers will give 250 patients questionnaires, blood and urine tests, and measure grip strength and body composition. They will then see if these measures are l…

This observational study at Brigham and Women's Hospital will use advanced MRI scans to see if brain activity and structure can predict recovery in 50 people who are comatose after a cardiac arrest. Participants will have a special MRI during their standard scan and be followed f…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study looks at how people with ME/CFS (chronic fatigue syndrome) and people with heart conditions feel after a bike exercise test. Researchers want to see if the type and timing of symptoms after exercise are different between the two groups. 80 adults will take part, and th…

After a cardiac arrest, many patients remain comatose and are at risk of further brain injury. Doctors currently measure brain oxygen by drawing blood from the jugular vein and sending it to a lab, which takes time. This study tests a special catheter that can measure oxygen leve…

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study looks at people who had a heart attack and also developed a dangerous heart rhythm (ventricular arrhythmia) while still in the hospital. Researchers want to learn more about how these patients are treated and how many die after leaving the hospital. The study does not …

This study tests whether paramedics can safely place a small tube in the leg artery of people having a cardiac arrest outside the hospital. The tube allows continuous blood pressure monitoring, which may help doctors give the right amount of medication to keep the heart pumping. …

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study explores whether drones can deliver automated external defibrillators (AEDs) to people experiencing cardiac arrest in rural areas faster than traditional emergency responders. Researchers will compare arrival times and see if drone delivery is practical enough to test …

This study looks at how artificial intelligence (AI) can help emergency call operators quickly identify life-threatening situations like cardiac arrest, stroke, or severe breathing problems. Researchers will analyze millions of past emergency calls to train AI models to recognize…

This study looks at how much pain people feel after a cardiac arrest while they are in the intensive care unit. Researchers will track pain using special scales, even in patients who are unconscious or on a breathing machine. The goal is to understand how pain affects recovery, s…

This study looks at whether checking pupils and brain oxygen levels right before starting ECMO can help predict neurological recovery in cardiac arrest patients. Researchers will measure these in 45 adults being evaluated for ECMO, before and after the procedure. The goal is to s…

This study is testing different treatments to reduce major complications and improve survival in 600 adults who need ECMO—a machine that does the work of the heart and lungs. Researchers will compare how well these treatments work in the first 28 days. The goal is to find safer, …

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This study looks at whether long-term stress, measured by cortisol levels in hair, is linked to cardiac arrest. Researchers will take a small hair sample from 136 patients who had a cardiac arrest or heart attack. The goal is to see if higher stress levels over the past three mon…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study tests whether a mixed reality (MR) system called HEROS 4.0 can teach CPR as effectively as traditional instructor-led classes. 120 adults who haven't had CPR training in the last year will be split into two groups: one using MR and one using standard video and in-perso…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study aims to find genetic causes of out-of-hospital cardiac arrest in people aged 18–50 in Lombardy, Italy. Researchers will analyze blood samples from 1,725 patients and also check family members for inherited heart risks. The goal is to better understand why cardiac arres…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study tests whether a machine-learning model can predict serious heart events in children admitted to the hospital. The model alerts doctors when a child may need a palliative care consultation. Researchers will compare outcomes before and after the model is used, involving …

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can help doctors better understand, diagnose, and treat different heart conditions. Researchers will track participants' health over ti…

This study tests whether improved telephone instructions for CPR can reduce the time without chest compressions when using an AED. About 80 volunteers will act as single rescuers in a simulated cardiac arrest. Half will get standard phone CPR guidance, and half will get enhanced …

This study creates a large collection of blood, tissue, and medical information from up to 5,000 people with or at risk for pediatric heart disease. Researchers will use these samples to better understand the disease and find new ways to diagnose or treat it in the future. Partic…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This registry is collecting information from 8,000 people undergoing heart or chest surgery. The goal is to see how factors before and during surgery relate to serious complications like death, shock, or infection. By analyzing this data, researchers hope to find ways to improve …

This study watches how hospital staff give breaths during CPR to adults whose hearts stop. It will measure the rate and volume of breaths and see which levels are linked to restarting the heart and surviving 30 days. The goal is to find the best ventilation approach during CPR.

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study looks at whether combining blood tests and brain ultrasound can better predict how well someone recovers from a cardiac arrest. Researchers will enroll 50 adults and check their blood for proteins linked to inflammation and use ultrasound to measure brain blood flow an…

This study is testing whether giving probiotics after heart surgery can improve recovery by changing the bacteria in the gut. Researchers will measure certain chemicals in the blood that come from gut bacteria. The trial involves 30 adults scheduled for heart surgery, who will re…

This study looks at how the brain, nerves, and blood vessels interact in 80 adults having heart surgery. Researchers will measure brain activity, blood flow, and heart reflexes to better understand the link between heart disease and depression. The goal is to develop new tools fo…

This study aims to improve how doctors predict the risk of sudden cardiac death or heart failure in people with inherited heart diseases. Researchers will use artificial intelligence to analyze data from 1,000 participants, including medical history, ECGs, imaging, genetic tests,…

This study collects information from trauma patients who experienced cardiac arrest due to injury. Researchers will review medical records to see how different pre-hospital treatments, like breathing tubes or medications, relate to survival. The goal is to find patterns that coul…

This study follows people who survived a cardiac arrest and received ultra-rapid cooling treatment in a previous study. Researchers will check their health and survival status over 5 years through phone interviews and medical records. The goal is to understand the long-term effec…

This study is looking for proteins, metabolites, and platelet changes in the blood that could predict whether a person will survive after receiving ECPR, a machine that takes over heart and lung function during cardiac arrest. Researchers will study blood samples from 130 adults …

This study aims to uncover the molecular causes of secondary brain injury in patients who survive cardiac arrest. Researchers will analyze cerebrospinal fluid from 60 participants using advanced techniques to identify changes in genes, proteins, and other molecules. The goal is t…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

This study tests whether a balloon device, called REBOA, can be safely used by emergency teams outside a hospital to improve blood flow in people whose heart has stopped (cardiac arrest). The balloon is inserted into the main artery and inflated to redirect blood to the heart and…

This study looks at why the airway sometimes closes during CPR for people who have a cardiac arrest outside the hospital. Researchers will analyze breathing data from 150 adults to see how common this closure is and whether it affects the chances of restarting the heart. The goal…

This study tests a program called Heart-to-Heart, where community health workers help low-income patients make informed choices about cardiac rehab after a heart event. About 50 adults from Johns Hopkins Hospital will take part. The goal is to see if the program is practical and …

This study looks at rules doctors use to decide when to stop trying to revive someone after a cardiac arrest outside the hospital. These rules were made in Western countries, and this study checks if they work for people in Asia. Researchers will study 140,000 patients to see if …

This study tests an AI system that reads blood pressure signals during CPR to tell rescuers if they are compressing the wrong part of the chest. In about half of cardiac arrest patients, standard chest compressions accidentally press on a valve in the heart, reducing blood flow. …

This study explores using drones to quickly deliver automated external defibrillators (AEDs) to people helping someone having a cardiac arrest outside a hospital. Researchers will test the delivery process with training manikins and interview people with and without cardiac arres…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study is a registry that will collect detailed information from 400 people who had a cardiac arrest outside of a hospital. The goal is to better understand what happens before, during, and after the event, so doctors can improve care and survival rates. Participants are foll…

This study collects small heart tissue samples from 400 adults undergoing heart procedures. Researchers will analyze these samples to find new markers that could help diagnose heart diseases earlier and better understand how the heart works in health and disease. The goal is to i…

This study looks at whether MRI scans can help predict serious heart events in people who have implanted heart devices like pacemakers or defibrillators. Researchers will scan 1,500 adults before they get their device and track their health for years. The goal is to see if MRI fi…

This study tests a portable MRI machine to look for brain injury in patients who have had a cardiac arrest. Researchers will scan the brain multiple times over several days to see how injuries change. The goal is to make brain imaging available at hospitals without specialized sc…

This study compares two ways of training emergency teams to handle adult cardiac arrest: training in the actual emergency room (in-situ) versus training in a separate simulation center (off-site). About 100 healthcare professionals from two hospital campuses will participate. The…

This study follows 700 patients who received ECMO after cardiac arrest to find out what predicts survival and good brain function. Researchers will also check if pre-primed ECMO machines work safely and how patients fare years later. The goal is to help doctors choose the right p…

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study tests whether a serious game (a digital learning tool) can improve critical care nurses' knowledge of targeted temperature management—a cooling treatment used after cardiac arrest. 120 nurses from adult ICUs will be split into two groups: one gets standard lectures, th…

This study is testing whether adding genetic and imaging information to standard risk assessments can better predict heart disease in 30,000 healthy Italian adults aged 40-80. Participants will have their risk calculated using traditional methods and then again with the added dat…

This study looks at whether using a special heart ultrasound (called TEE) during emergencies helps doctors make better decisions and improves patient outcomes. Researchers will track 1,000 critically ill adults in the ER or ICU who receive this test as part of their care. The goa…

This study is testing a virtual patient navigation program for 260 English, Chinese, or Spanish speakers with breast cancer or heart disease. The goal is to see if a phone-based portal can help underserved people get the support they need, even though it won't fully replace in-pe…

This study looks at how the height of a hospital bed affects the quality of CPR given to children. 25 pediatric doctors will each perform chest compressions on a child-sized manikin at four different bed heights. The goal is to find the bed height that helps doctors give the best…

This study is tracking over 5,000 adults who had a cardiac arrest outside the hospital to learn what causes it and who is at risk. Researchers will look at health habits, chronic diseases, and develop a prediction model. The goal is to find new ways to prevent these life-threaten…

This study looks at a better way to predict recovery in people who remain unconscious after a cardiac arrest. Doctors often struggle to know who will wake up, which can lead to early decisions to stop life support. The study will follow 600 patients in the US, Brazil, and Italy, …

This study tests a new tool called PRECOM that uses brain wave signals to predict whether coma patients after cardiac arrest will wake up within three months. Researchers will enroll 100 adults in French ICUs and compare the tool's predictions to actual outcomes. The goal is to i…

This study follows over 10,000 Moroccan adults for 10 years after a heart screening. Researchers will track heart attacks, strokes, and heart-related deaths to build a risk score tailored to the Moroccan population. The goal is to better predict and prevent heart disease in Moroc…

This study is building a biobank of blood and tissue samples from 500 patients undergoing cardiac surgery. Researchers will analyze these samples to better understand the causes and progression of heart disease. The goal is to improve future diagnosis and treatment, but no new th…

This study tests a special rehabilitation program designed to help people who survived a sudden cardiac arrest return to work. The program includes tailored support and is compared to usual care alone. About 214 survivors will take part, and researchers will track their work stat…

This study tracks 150 adults in cardiac rehab to see if men and women differ in how much they move during and up to 6 months after the program. Participants wear activity trackers and complete fitness tests at three visits over 10 months. The goal is to understand barriers to sta…

This study measures how much air actually reaches the lungs when rescuers give breaths by hand during cardiac arrest. It compares two common airway devices—tracheal tubes and laryngeal mask airways—using a small flow sensor. The 30 participants are already part of a larger trial …

This study watches 250 adults who are unconscious after a cardiac arrest to see if early brain tests can predict when they will wake up. Researchers use tools like EEG and ultrasound to monitor the brain. The goal is to find reliable signs of recovery, not to test a new treatment…

This study looks at how care in the emergency room (ER) after a heart attack affects short-term survival. Researchers will review records from 6,000 adults who had a heart attack outside the hospital and were revived in the ER. The goal is to find which ER treatments and timing h…

This study looks at how frailty—a state of increased weakness—impacts the results of CPR in patients who need emergency resuscitation. Researchers will track factors like the reason for the emergency, how long CPR lasts, and what equipment is used. The goal is to better understan…

This study aims to see if voice recordings from a smartphone can help detect heart disease. Researchers will collect voice samples and health data from up to 1 million adults using the Mayo Clinic app. No treatment is given; the goal is to gather information for future AI tools.

This study compares different scoring systems to predict brain damage in patients admitted to the ICU after cardiac arrest. Researchers will calculate early prognosis scores using clinical and lab values to see which system best identifies patients at risk. The goal is to help do…

This study watches how doctors and nurses perform CPR on children who have had a cardiac arrest. Researchers will check if following American Heart Association guidelines for chest compression depth, rate, and timing leads to better outcomes. Up to 7,000 children across multiple …

This study is testing a new training program that teaches doctors how to use a special ultrasound (TEE) during cardiac arrest. The program includes a lecture and hands-on practice with a simulator. Researchers are also developing an AI tool to assess how well doctors perform. The…

This study observes 128 critically ill ICU patients to see how two common sedatives—propofol and ketamine—affect the risk of severe drops in blood pressure or cardiac arrest during emergency intubation. Propofol can lower blood pressure, while ketamine may help maintain stability…

This study is for people starting a type of cancer drug called BTK inhibitors, which can sometimes cause irregular heartbeats. Researchers will implant a small heart monitor under the skin to watch for these heart rhythm problems continuously for up to 5 years. The goal is to lea…

This study will follow 10,000 people who come to a clinic in Davos, Switzerland for cardiac rehabilitation after a heart attack, surgery, or other heart problem. Researchers will collect health data, blood samples, and genetic information to understand what helps people recover b…

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…

This study is observing 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and at least one heart condition. Researchers will track their health for two years, recording lung flare-ups, heart complications, hospital visits, and quality of life. The go…

This study explores whether using emotional sounds—like a patient's own name spoken by a family member—can improve brain wave tests that help predict recovery in people with disorders of consciousness. Researchers will compare brain responses to familiar versus unfamiliar voices …

This study looks at 840 people in Paris whose hearts stopped and didn't restart with standard CPR. They received a special life-support machine called ECMO to keep blood flowing. Researchers will track how many survive for one year and how well their brains recover. The goal is t…

This study is testing a special heart monitor, the BIOMONITOR IV, in 300 people with heart failure who also have irregular heartbeats. The device tracks heart activity, fluid levels, and breathing patterns to see if it can predict when heart failure gets worse. Researchers hope t…

This study tests whether a clear plastic box placed over a patient's head during CPR can reduce the spread of viruses like COVID-19 to healthcare workers. Researchers will simulate cardiac arrest scenarios with 240 participants, measuring how well the box works during chest compr…