Could chilling the body after cardiac arrest save more brains?

NCT ID NCT06776549

Recruiting now Disease control Sponsor: Kagawa University Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This trial asks whether cooling the body to 33-34°C after a cardiac arrest treated with ECMO improves survival and brain function compared to keeping a normal temperature. It includes adults aged 18-75 who had an out-of-hospital cardiac arrest with certain heart rhythms. Participants are randomly assigned to either hypothermia or normothermia, and the study tracks survival, neurological outcomes, and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Temperature control (hypothermia at 33-34°C versus normothermia)
What this could lead to: If cooling improves outcomes, it could become a standard way to protect the brain and boost survival after cardiac arrest requiring ECMO.
What could go wrong: The trial is still testing this approach, and cooling may not improve outcomes or could carry risks like infection or bleeding. Results are not yet known.

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Conditions

The condition(s) this trial relates to.

cardiac arrest Out-of-Hospital Cardiac Arrest post-cardiac arrest syndrome sudden cardiac arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ECMO TREATMENT OUT-OF-HOSPITAL CARDIAC ARREST (OHCA) POST-CARDIAC ARREST SYNDROME TEMPERATURE

Contacts and locations

Locations

Asahikawa Medical University Hospital
NOT_YET_RECRUITING

Asahikawa, Hokkaido, 0788510, Japan
Ebina General Hospital
RECRUITING

Ebina, Kanagawa, 2430432, Japan
Hitachi General Hospital
RECRUITING

Hitachi-shi, Ibaraki, 317-0077, Japan
Hokkaido University Hospital
RECRUITING

Sapporo, Hokkaido, 0608648, Japan
Hyogo Emergency Medical Center
RECRUITING

Kobe, Hyōgo, 6510073, Japan
Hyogo Prefectural Kakogawa Medical Center
RECRUITING

Kakogawa, Hyōgo, 6758555, Japan
Institute of Science Tokyo Hospital
RECRUITING

Tokyo, 1138519, Japan
Japanese Red Cross Musashino Hospital
RECRUITING

Tokyo, 1808610, Japan
Kagawa University Hospital
RECRUITING

Kita-gun, Kagawa-ken, 7610793, Japan
Keio University Hospital
RECRUITING

Tokyo, 1608582, Japan
Kurume University Hospital
RECRUITING

Kurume, Fukuoka, 8300011, Japan
Kyoto Second Red Cross Hospital
NOT_YET_RECRUITING

Kyoto, Kyoto, 6028026, Japan
National Hospital Organization Disaster Medical Center
RECRUITING

Tokyo, 1900014, Japan
Nippon Medical School Hospital
RECRUITING

Tokyo, 1138603, Japan
Okayama University Hospital
RECRUITING

Okayama, Okayama-ken, 7008558, Japan
Okinawa Prefectural Nanbu Medical Center & Children's Medical Center
RECRUITING

Shimajiri-gun, Okinawa, 9011193, Japan
Osaka Saiseikai Senri Hospital
RECRUITING

Suita, Osaka, 5650862, Japan
Oshima Prefectural Hospital
RECRUITING

Amami, Kagoshima-ken, 8940015, Japan
Saiseikai Yokohamashi Tobu Hospital
RECRUITING

Yokohama, Kanagawa, 2308765, Japan
Saitama Red Cross Hospital
RECRUITING

Saitama, Saitama, 3308553, Japan
Sapporo Medical University Hospital
RECRUITING

Sapporo, Hokkaido, 0608556, Japan
Sendai Medical Center
RECRUITING

Sendai, Miyagi, 9838520, Japan
St. Luke's International Hospital
RECRUITING

Tokyo, 1048560, Japan
Tohoku University Hospital
RECRUITING

Sendai, Miyagi, 9808574, Japan
Tokyo Metropolitan Bokutoh Hospital
RECRUITING

Tokyo, 1308575, Japan
Tokyo Metropolitan Tama Medical Center
RECRUITING

Tokyo, 1838524, Japan
Tottori Prefectural Central Hospital
RECRUITING

Tottori-shi, Tottori, 6800901, Japan
Toyooka Public Hospital
RECRUITING

Toyooka, Hyōgo, 6688501, Japan
Tsuyama Chuo Hospital
RECRUITING

Tsuyama, Okayama-ken, 7080841, Japan

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