Cardiac arrest

This study looks at whether giving people a heart-lung machine (ECPR) right where they collapse from a cardiac arrest can help more of them survive to leave the hospital. Researchers will compare people who get this extra treatment with those who get standard CPR and care. The st…

This phase 3 trial tests whether the drug troriluzole can slow the progression of spinocerebellar ataxia, a rare genetic disorder that affects coordination and balance. About 300 adults with different types of SCA are randomly assigned to take either troriluzole or a placebo dail…

This study tests whether giving a drug that blocks a key inflammatory protein (TNF-alpha) within 6 hours after a cardiac arrest can help more people survive. The trial includes 208 adults who remain unconscious after their heartbeat is restored. The goal is to see if the drug imp…

This study looks at 3,500 unconscious patients who survived a cardiac arrest to find the best combination of sedation, fever control, and blood pressure management in the ICU. Each patient gets one of two levels for each factor (e.g., deep vs. light sedation, tight vs. loose feve…

This study is tracking 100 adults who receive an EluPro antibiotic-eluting envelope during implantation of a heart device (like a pacemaker). The envelope slowly releases antibiotics to prevent infection. Researchers are monitoring complication rates in real-world use to see how …

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This study tests whether a weekly injection of CagriSema (a combination of two drugs) can reduce the risk of heart attacks, strokes, and other heart-related events in people with established cardiovascular disease. About 7,100 participants will receive either CagriSema or a place…

This study tests a technique called acute normovolemic hemodilution (ANH) in 2000 high-risk heart surgery patients. Before the heart-lung machine is used, doctors remove some blood and replace it with fluids. The goal is to see if this reduces the number of patients who need a bl…

This phase 3 trial tests whether a monthly injection of pelacarsen can reduce major heart problems like heart attacks and strokes in people with high levels of Lp(a), a genetic risk factor. Over 8,000 participants with existing heart disease are being followed for several years. …

This study follows 2000 people who have or will get the OmniaSecure defibrillation lead, a wire that helps control dangerous heart rhythms. Researchers will track how often the lead causes problems over 5 years. The goal is to make sure the lead is safe and works as expected in e…

This study compares vasopressin to the standard drug epinephrine for newborns who need CPR at birth. Only 8 babies were enrolled, and the hospital was randomly assigned to use one drug for a year. The goal is to see which drug helps restart the heart faster, but the results are v…

This pilot study tests whether giving packed red blood cells during in-hospital cardiac arrest can help deliver oxygen to the brain and other vital organs. Researchers plan to enroll 30 adults who have been in cardiac arrest for at least 10 minutes, comparing blood transfusions t…

This study tests three ways emergency responders help children breathe: a bag-mask, a throat tube, or a breathing tube. It includes 3,000 children under 18 with cardiac arrest, severe injury, or breathing failure. The goal is to see which method leads to more days alive and out o…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This trial tests whether a procedure called catheter ablation works better than anti-arrhythmic drugs for people with structural heart disease who have had a dangerous fast heart rhythm (ventricular tachycardia). About 162 participants will be randomly assigned to either ablation…

This study tests whether a gel containing silver diamine fluoride can stop cavities in preschool children as effectively as the standard liquid version. About 630 healthy children with at least one cavity will receive the gel or solution every six months for 30 months. The goal i…

This study tests whether giving sodium bicarbonate (a common substance) during a cardiac arrest in the hospital helps restart the heart. About 778 adults who have already received adrenaline will be randomly assigned to get bicarbonate or a placebo. The main goal is to see if it …

This study tests whether giving patients capsules containing gut bacteria (called Probacine) before and after heart surgery can reduce gut injury and organ failure. Researchers will enroll 500 adults undergoing cardiovascular surgery. The goal is to see if changing the gut microb…

This study tests whether wearing electrically insulated gloves during defibrillation allows rescuers to continue chest compressions without stopping, which current guidelines require for safety. Researchers will compare survival and recovery rates between standard CPR and CPR wit…

This study planned to test whether a direct injection of potassium chloride could help people whose hearts had stopped and were not responding to standard shocks. The trial was withdrawn before any patients were enrolled, so no results are available.

This study follows 10 people who already received LX2020 gene therapy for arrhythmogenic cardiomyopathy caused by a PKP2 gene mutation. Researchers will monitor them for years to see if the treatment remains safe and continues to help control the disease. The goal is to understan…

This early-stage trial tests a gene therapy called LX2020 for people with a heart condition called arrhythmogenic cardiomyopathy, caused by a change in the PKP2 gene. The study involves 10 adults who already have a defibrillator implanted. The main goal is to see if the treatment…

This study explores whether a simple, non-invasive leg movement test can measure blood vessel health in older adults. Researchers will use ultrasound to track blood flow changes after a passive leg movement, comparing young healthy people and older patients undergoing heart tests…

This large study tested whether taking daily vitamin D3 and omega-3 (fish oil) supplements can lower the risk of developing cancer, heart disease, or stroke. Over 25,000 healthy older adults (men 50+, women 55+) took the supplements or placebos for about 5 years. The goal is to s…

This study tests a nurse-led education program designed to help women in cardiac rehab address sexual concerns after a heart event. Sixty-six women will be randomly assigned to either the program or usual care. The goal is to see if the program improves sexual function, mood, and…

This study tests whether adding blood flow restriction (BFR) to standard resistance training helps heart rehab patients get stronger and healthier. Twenty adults with stable heart disease will do exercises with and without a special cuff that limits blood flow to the arms and leg…

This study tests whether a nerve block given before heart surgery can reduce pain and the need for opioid painkillers afterward. About 150 adults having heart surgery will receive either a long-acting or standard form of the numbing drug bupivacaine via ultrasound-guided injectio…

This study tests a short program that helps heart patients and their families explore what gives life meaning during cardiac rehab. About 80 people in Denmark will try one of three formats: one-on-one, with a relative, or in a group. The goal is to see if this approach can reduce…

This study tests whether a 12-week web-based support program can improve wellbeing in adults who survived a cardiac arrest 1 to 3 months earlier. The program includes educational modules, videos, breathing exercises, and a chat forum. Researchers will compare 120 participants who…

This study tracks 120 adults with heart disease and at least two other long-term illnesses to see how often dangerous drug interactions happen. Researchers check medications, including over-the-counter and herbal products, and follow participants for a year. The goal is to unders…

This study looks at whether the amount of carbon dioxide a person breathes out during CPR can help predict if they will survive a cardiac arrest that happens outside a hospital. Researchers are reviewing records from 3,500 adults who had a cardiac arrest and were treated by emerg…

This study examines how different hospital treatments—sedation, temperature control, and blood pressure management—after a cardiac arrest impact kidney function. Researchers will follow 3500 adults who were resuscitated from a heart attack outside the hospital. The goal is to und…

This study looks at whether training nurses with realistic simulations helps them perform CPR and use defibrillators better during cardiac arrest. About 134 experienced nurses will take part. The goal is to improve patient survival by boosting nurses' skills.

This registry follows 545 people with arrhythmia who received a heart ablation using the DiamondTemp system. Researchers will track how many stay free of their heart rhythm problem and how many have serious side effects over 12 months. The goal is to see how well the device works…

This study examines whether a low pulse pressure (the difference between top and bottom blood pressure numbers) in the first hours after a cardiac arrest is linked to early death. Researchers will analyze data from 3500 patients who had a cardiac arrest outside the hospital and a…

This study tracks over 1,700 heart patients who had hip or knee replacement surgery. Researchers want to see how often bleeding or blood clots happen in the months after surgery. The goal is to find better ways to prevent these complications.

This large trial tests whether a coordinated community approach can improve survival and brain function after cardiac arrest. The plan includes faster 911 dispatch, CPR instructions over the phone, public CPR and AED training, and better first responder performance. About 20,000 …

This study looks at blood samples from 682 adults who survived a cardiac arrest outside the hospital. Researchers are analyzing proteins to find new markers that could help predict recovery and understand the body's response after the heart stops. The goal is to discover potentia…

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study involves 100 adults who have a cardiac arrest outside the hospital. Doctors will use portable ultrasound, blood tests, and a digital checklist to quickly find reversible causes, like a blocked artery or drug overdose. The goal is to see how often these causes are found…

This study is a large registry that collects medical data and tissue samples from 30,000 people with heart disease and healthy volunteers. Researchers will analyze this information to better understand risk factors, treatments, and outcomes for various heart conditions. The goal …

This study tests whether the PulsePoint app can increase the number of people who receive CPR or a defibrillator from bystanders before paramedics arrive. About 340 adults who suffer sudden cardiac arrest in public places will be included. Half of the 911 calls will trigger the a…

This study looks at whether a simple, painless eye ultrasound can help doctors predict brain damage and survival in people who have had a cardiac arrest. Researchers will measure the optic nerve sheath diameter in 80 adults and compare it with other tests. The goal is to find a f…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …

This study tests whether a virtual group program can help people who survived a cardiac arrest and their relatives. About 50 participants will either join the virtual group or receive a digital booklet. The goal is to see if the program is practical and helpful for improving reco…

This study looks at how well air and blood mix in the lungs of 10 adults on a heart-lung bypass machine (VA ECMO). Researchers will adjust the breathing machine settings using special monitoring tools to see if they can improve oxygen levels. The goal is to gather information, no…

This study looks at how being in a hospital intensive care unit (ICU) after heart surgery affects your body's natural sleep-wake cycle. Researchers will track sleep patterns and thinking ability in 15 adults to see if disrupted rhythms slow down recovery. The goal is to understan…

This study looks at whether a new first responder system in the Swiss canton of Zug helps people who have a cardiac arrest outside of a hospital. Researchers will compare survival rates and heart rhythms before and after the system was put in place. The study includes 250 adults …

This study follows 10,000 people with both obstructive sleep apnea and high blood pressure over many years. Researchers will track how well patients use CPAP machines and blood pressure medications, and whether this reduces the chance of heart attacks, strokes, heart failure, or …

This study aimed to see if using a special pad along with a standard closure device could help patients get out of bed sooner after a heart catheterization. It was planned for adults having the procedure through the groin. However, the study was withdrawn before any participants …

This study uses a special 3D ultrasound probe placed in the throat to see inside the heart during CPR. Researchers want to find the best location on the chest to push, so blood flows better. They will test this in 50 adults who had a cardiac arrest outside the hospital.

This study looks at whether a forehead EEG monitor (BIS) can be used during out-of-hospital cardiac arrest to track brain activity. Researchers will check if the device works in the ambulance and emergency room, and whether its readings help predict brain injury. The study involv…

This study tests an artificial intelligence system that analyzes brain CT scans to predict how well someone will recover after a cardiac arrest. Researchers will look at data from 350 patients who survived a cardiac arrest in Taiwan between 2014 and 2020. The goal is to see if th…

This registry follows 75 pregnant women with heart disease to better understand the risks and outcomes for both mother and baby. Researchers will track health data for one year and check vital status at five years. The goal is to fill knowledge gaps and improve future care for th…

This study follows 347 heart surgery patients to understand why some develop swallowing problems (dysphagia). Researchers will use special camera tests to watch how patients swallow and look for risk factors. The goal is to create simple tools that doctors can use at the bedside …

This study is following 10,000 adults who are having a heart MRI for medical reasons. Researchers want to see if the MRI results can help predict who will have heart problems in the future, like heart attacks or heart failure. The goal is to better understand how MRI scans can gu…

This study aimed to see if virtual reality training helps first-year emergency residents manage traumatic cardiac arrest faster than e-learning. It was withdrawn before enrolling any participants, so no results are available. The trial was designed to compare time to critical act…

This study was designed to measure blood pressure in adults experiencing cardiac arrest and to see how a device called an impedance threshold device (ITD) affects it. The ITD is placed on the airway to help blood flow to the heart. However, the study was withdrawn before enrollin…