Cardiac arrest

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This study tests whether an external abdominal tourniquet can temporarily block blood flow to the lower body during cardiac arrest, redirecting it to the brain and heart. Researchers will try it on 5 adults with non-traumatic cardiac arrest outside a hospital. The goal is to see …

This study compares two CPR methods for newborns with cardiac arrest: a new technique that combines chest compressions with sustained lung inflation versus the standard 3:1 compression-to-ventilation ratio. Researchers will enroll 554 newborns across multiple hospitals to see whi…

This study tests whether mirabegron, a drug typically used for overactive bladder, can reduce dangerous heart rhythms in people with heart disease. Twenty adults with an implanted defibrillator and frequent ventricular tachycardia will take the drug for two months. Researchers wi…

This study looks at whether giving volunteer community responders a small, portable defibrillator (about the size of a chocolate bar) helps them treat people having a cardiac arrest outside the hospital. Around 1,000 volunteers in Singapore will carry the device for up to a year …

This early study tests a special cap that shines near-infrared light on the heads of infants who have had a cardiac arrest in the hospital. The light is meant to reduce brain injury caused when blood flow returns. The trial will include 30 infants with heart disease and will chec…

This study tests a new method for closing the breastbone after coronary artery bypass graft (CABG) surgery using special knotless barbed sutures and a skin adhesive. Researchers will compare 401 adults who receive this new closure to past patients who had standard closure. The go…

This trial will test whether using smaller breaths (350ml) during CPR helps more people survive cardiac arrest compared to standard larger breaths (600ml). Paramedics will treat 1656 adults with presumed cardiac arrest. The main goal is to see if the smaller breaths lead to more …

This study tests whether using special devices to precisely control breathing during CPR can help more people survive a cardiac arrest. About 852 adults who have a cardiac arrest in the hospital will be randomly assigned to either standard manual breathing help or breathing tailo…

This study looks at whether giving a smaller dose of epinephrine (0.5 mg) during a heart attack outside the hospital helps more people survive with better brain function than the usual dose (1 mg). About 4,336 adults will be randomly assigned to receive either the low or standard…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study tests whether moving cardiac arrest survivors to a specialized hospital improves their recovery. About 1,600 adults who were revived after an out-of-hospital cardiac arrest will be randomly assigned to either stay at the nearest hospital or be transferred to a specialt…

This trial tests whether cooling patients to 33°C (therapeutic hypothermia) improves survival and brain function compared to keeping them at normal body temperature after an in-hospital cardiac arrest. About 788 comatose adults who had a cardiac arrest in the hospital will be ran…

This study tests two different ways to program an implantable defibrillator (ICD) to stop dangerous fast heartbeats. About 4,000 people with heart disease who need an ICD will be assigned to one of two pacing patterns (burst or ramp) and followed for up to 10 years. The goal is t…

This study tests whether taking vitamin B supplements before and after heart surgery can lower the chance of serious problems like heart attack, stroke, or irregular heartbeat. About 1,000 adults having heart surgery will take either vitamin B or a placebo daily for 6 months afte…

This study looks at whether a medical-grade smartwatch (CardioWatch 287-2) can improve a 13-week virtual cardiac rehab program for people with heart disease. About 216 participants will either use the watch or not, and researchers will compare their progress in areas like exercis…

This study tests a new CPR method called Bio-CPR, which synchronizes chest compressions with ventilation using a machine. Researchers will compare it to standard CPR in 408 adults who have a witnessed cardiac arrest. The goal is to see if this coordinated approach improves breath…

This study tests Mobili®, a portable digital dispenser that automatically gives the right pills at the right time. Researchers will enroll 96 adults with diabetes or heart disease who take at least two daily medications. Participants use the device for a period, and the study mea…

This study tests two heart ablation methods—right atrial only vs. bi-atrial—to see which better prevents fainting caused by reflex syncope. Fifty adults aged 18–60 with severe, recurrent fainting will be monitored with an implantable loop recorder. The goal is to find the most ef…

This study tests a new way to place an emergency IV line through the umbilical cord in newborns who need urgent resuscitation. The procedure aims to deliver adrenaline faster than the standard method. Researchers will enroll 26 full-term babies to see if the new technique can res…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study tests a small, handheld ECG device that records heart activity when held against the chest and sends the data via smartphone to a doctor. Researchers will enroll 594 adults with known or suspected heart conditions to see if the new device is as good as the standard 10-…

This study tests a new cardiac MRI method called Free-Running Framework (FRF) that lets patients breathe normally and skips the sticky ECG electrodes. It captures a 3D image of the whole heart in one go, potentially making scans faster and more comfortable. Researchers will compa…

This study will check if a fast, bedside heart ultrasound performed by emergency doctors or interpreted by artificial intelligence can accurately detect heart problems in children who already have heart disease. About 200 children aged 0-21 will be included. The results will be c…

This study tests whether a simple bedside ultrasound of the inferior vena cava can detect low blood volume in shock patients as accurately as the standard invasive central venous pressure monitoring. Researchers will enroll 80 adults with shock from blood loss, infection, or othe…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This pilot study explores whether non-drug strategies like virtual reality or relaxing soundscapes can reduce anxiety and pain in adults undergoing scheduled coronary angiography or angioplasty. Participants will be assigned to listen to calming sounds, experience a virtual reali…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This study tests whether adding a short, guided mindfulness meditation session to standard cardiac rehabilitation can help heart patients feel better and control their blood pressure. Eighty adults with heart disease will be split into two groups: one gets standard rehab plus med…

This study will compare cannabis, opioids, and two non-drug therapies (MIRE and TENS) in 1,000 people with chronic pain or circulatory disorders. The goal is to find safer, less addictive pain relief options. Researchers will measure changes in pain and nerve function using objec…

This study will take standard heart CT scans from 1000 adults with structural heart disease and use a super-computer to create ultra-high-resolution images. The goal is to see if these enhanced images show more detail than the originals. No new treatments are being tested; it's a…

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study will interview 15 people from ethnic minority backgrounds in the UK who have heart disease. The goal is to understand their views on the diet and lifestyle advice they get from doctors, and whether it fits their cultural and religious customs. Researchers hope to learn…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study looks at whether a brief training video can boost police officers' confidence and willingness to use an AED (a device that shocks the heart) during cardiac arrest, especially on women. About 30 officers will take surveys before and after watching the video. The goal is…

This observational study at a French hospital will ask 20 heart rehab patients and their care teams about what stops them from getting or offering psychological and social support. The goal is to understand these barriers so that hospitals can better help patients return to work …

This study will use a non-invasive ultrasound test called Transcranial Doppler to measure blood flow in the brains of 125 children in the Pediatric Intensive Care Unit. Researchers want to see how brain blood flow changes during critical illness and whether those patterns relate …

This study aims to see if improving how emergency dispatchers handle calls and model their actions can speed up the detection of cardiac arrest and improve CPR quality. Researchers will study 4,000 people who experience cardiac arrest outside of a hospital. The goal is to learn i…

This study follows 75 volunteer first responders who are alerted via a smartphone app to help in out-of-hospital cardiac arrests. Researchers want to understand how these stressful events affect the volunteers' mental health and whether a structured follow-up conversation can hel…

This study examines whether volunteers alerted by a smartphone app can improve survival for people who have a cardiac arrest outside the hospital. Researchers will compare outcomes for about 5,200 adults who either did or did not receive help from these first responders. The goal…

This study will collect information on 1,200 emergency intubations across multiple hospitals in Taiwan. Researchers will track how often the tube is placed correctly on the first try and how often serious problems like low oxygen, low blood pressure, or cardiac arrest occur. The …

This study tests whether showing real-time visual feedback to EMS responders helps them deliver the right amount of air during simulated CPR. 80 rescuers will give breaths to a mannequin with and without feedback, using two different CPR strategies. The goal is to see if feedback…

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study will look at how consistently nearly 6,000 adults in Italy take three newer cholesterol-lowering drugs (inclisiran, evolocumab, and alirocumab) over the long term. Researchers will analyze prescription records to measure adherence and persistence in everyday medical pr…

This study explores whether drones can deliver automated external defibrillators (AEDs) faster than traditional ambulances in simulated cardiac arrest scenarios. Researchers will compare drone and ambulance response times in different city locations and traffic conditions. Twenty…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and AI tools to understand why some patients respond well to treatment while others do not. The goal is to find better…

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This study looks at 100 adults who needed a breathing machine after a heart attack or cardiac arrest. Researchers want to see how often acid-base problems happen and compare the settings doctors used with those suggested by a computer algorithm. The goal is to improve future care…

This study tests a drug called GC7 in 20 people who have had a cardiac arrest and been revived. The goal is to see if GC7 can reduce cell damage caused by the sudden return of blood and oxygen. Researchers will measure stress levels in blood cells and look for signs of improved r…

This study tests a machine learning device that uses heart tracings (ECG) to predict if a person will have another cardiac arrest after being revived. Researchers will first see if EMS providers find the device useful in simulated scenarios, then test its accuracy in 68 real pati…

This study will test a simple score to predict which patients may become confused (delirium) after planned heart surgery. About 100 adults will be checked before surgery using memory, orientation, and frailty tests. The goal is to identify high-risk patients early so doctors can …

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study will follow 4,000 intensive care patients aged 80 and older to see how chronic and acute heart conditions impact their survival, daily function, and quality of life. Researchers will use simple tests to measure frailty and independence. The goal is to help doctors bett…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study looks at how often colon damage (ischemia) happens in people who survive cardiac arrest and receive CPR. Researchers will perform a bedside colonoscopy 24-36 hours after CPR to check for colon injury. The goal is to better understand this complication and improve care …

This study will collect information from 1,200 patients in the French West Indies and Guiana who received ECMO, a machine that helps the heart and lungs. Researchers aim to track survival rates and complications to better understand how ECMO works in this region. The study does n…

This study looks at whether measuring changes in exhaled carbon dioxide (a breath test) during a leg-raising maneuver can help predict if a critically ill patient needs more fluids. Doctors often struggle to balance giving enough fluids without causing harm from too much. The stu…

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…

This study looks at whether people with certain heart rhythm disorders also carry genetic variants linked to a rare muscle condition called non-dystrophic myotonia. Researchers will review medical records of 570 participants and invite some for a neurological exam and electromyog…

This study looks at whether getting a CT scan sooner after a person's heart stops outside the hospital and is revived can help them live longer. Researchers will review records from 5,000 adults treated at six hospitals in Taiwan. The goal is to find the best timing for CT scans …

This study looks at 5,000 patients who survived a cardiac arrest and were admitted to the intensive care unit (ICU). Researchers will use artificial intelligence to analyze past medical records and create a model that predicts how long a patient will stay in the ICU, their brain …

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…

This study will test whether an artificial intelligence (AI) system can detect pulmonary hypertension and other heart diseases using a smart stethoscope. Researchers will collect heart sound and ECG recordings from 1,000 adults already scheduled for routine echocardiography. The …

This study looks at how sleep disorders and problems with the body's automatic functions (like heart rate control) are linked in elderly people with heart disease. Researchers will study 210 patients aged 65 and older to find out how common sleep issues are and how they affect he…

This study compares a standard high-field MRI with a portable low-field MRI to see if the portable version can detect brain damage in people in a coma after cardiac arrest. Researchers will scan 60 participants (30 coma patients and 30 healthy volunteers) multiple times over two …