Could smaller breaths save more lives after cardiac arrest?
NCT ID NCT07479836
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This trial will test whether using smaller breaths (350ml) during CPR helps more people survive cardiac arrest compared to standard larger breaths (600ml). Paramedics will treat 1656 adults with presumed cardiac arrest. The main goal is to see if the smaller breaths lead to more patients having their heart restarted before reaching the hospital.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Low volume ventilation (350ml) vs high volume ventilation (600ml) during CPR
- What this could lead to
- If it works, this could establish a better way to ventilate patients during CPR, potentially increasing survival rates after cardiac arrest.
- What could go wrong
- This trial has not yet started recruiting. Even if successful, the benefit may be modest and limited to specific patient groups. Ventilation is just one part of CPR, so other factors also affect survival.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sunnybrook Health Sciences Centre
Toronto, Ontario, M4N3M5, Canada
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