Could a smarter breathing machine boost survival after cardiac arrest?
NCT ID NCT06836908
First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time
Summary
This study tests a new way of delivering breaths during CPR called chest compression synchronized ventilation (CCSV), which times each breath to occur between chest compressions. Researchers will compare it to standard ventilation in 50 adults who suffer cardiac arrest outside the hospital in Vienna. The goal is to see whether CCSV improves oxygen levels, blood flow to the brain, and 30-day survival.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- chest compression synchronized ventilation (CCSV)
- What this could lead to
- If CCSV proves better, it could become a new standard ventilation method during CPR, potentially improving survival and brain function after cardiac arrest.
- What could go wrong
- This is a small, early exploratory study in one city, so results may not apply broadly. The intervention is complex and may not show clear benefit over standard care.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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50 people
The number who actually took part.
- Started
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Jun 2024
- Finished
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Mar 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult out-of-hospital cardiac arrest patients in Vienna
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * OHCA * Correct endotracheal intubation (seen by capnography) * The patient is being treated by the Vienna Emergency Medical Services within the scope of emergency ventilation. * MEDUMAT Standard from Weinmann Emergency is used. * Mechanical ventilation is performed according to the specified indications. Exclusion Criteria: * Patients eligible for eCPR (as defined by the standard operating procedure of the Emergency Medical Service Vienna) * Patients recovering (reaching sustained ROSC) before starting mechanical ventilation or in the first three minutes of it * Any other mechanical ventilation during the ongoing CPR before study inclusion * Traumatic cardiac arrest * Suspected or known pregnancy * Clinically suspected (tension-)pneumothorax
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Medical University of Vienna
Vienna, 1090, Austria
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Mean arterial pressure after out-of-hospital cardiac arrest: the METAPHORE randomized trial
- Can tracking ambulance ventilators improve emergency breathing care?
- Blood tests may reveal brain recovery after cardiac arrest
- Can cooling after cardiac arrest change how the body burns fuel?
- Double shocks: could two defibrillators save more cardiac arrest patients?
- Balloon in the aorta could boost CPR success in cardiac arrest