Blood tests may reveal brain recovery after cardiac arrest
NCT ID NCT06471972
First seen Aug 21, 2026 · Last updated Aug 21, 2026
Summary
This study is looking at whether certain substances in the blood, called biomarkers, can help predict how well people recover after a cardiac arrest. Researchers will collect blood samples from about 1,500 adults treated in intensive care units after cardiac arrest. They will measure these biomarkers at several time points and then check each patient's functional outcome at 30 days and 6 months to see if the biomarkers are linked to recovery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to better ways to predict recovery and guide treatment for cardiac arrest survivors.
- What could go wrong
- This is an observational study, so it won't test a treatment. The biomarkers may not prove reliable in predicting outcomes.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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1,500 people
The number who actually took part.
- Started
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Oct 2023
- Expected to finish
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Dec 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult patients with an out-of-hospital cardiac arrest from sites participating in the biobank substudy of the STEPCARE trial will be included.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * From sites participating in the STEPCARE biomarker substudy and withOut-of-hospital cardiac arrest * Sustained ROSC - defined as 20 minutes with signs of circulation without the need for chest compressions * Unconsciousness defined as not being able to obey verbal commands (FOUR-score motor response of \<4) or being intubated and sedated because of agitation after sustained ROSC. * Eligible for intensive care without restrictions or limitations * Inclusion within 4 hours of ROSC Exclusion Criteria: * On ECMO prior to randomization * Pregnancy * Suspected or confirmed intracranial hemorrhage * Previously randomized in the STEPCARE trial.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Helsingborgs Hospital
Helsingborg, Sweden
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Helsinki Hospital
Helsinki, Finland
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Skåne University Hospital
Malmö, Sweden
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Skåne university hospital
Lund, Sweden
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Mean arterial pressure after out-of-hospital cardiac arrest: the METAPHORE randomized trial
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