CARDIAC ARREST

This study tests whether using special brain monitors (near-infrared light, ultrasound, and brain wave tracking) can help doctors better manage oxygen levels in the brain for people on life support after a cardiac arrest. The goal is to see if this approach increases the number o…

This study compares two types of CPR for people who have a cardiac arrest outside a hospital: hands-only CPR (chest compressions without rescue breaths) versus standard CPR (compressions plus rescue breaths). The trial will include over 3,000 adults whose cardiac arrest is witnes…

This phase 2 trial tests whether giving high-dose vitamin C and thiamine early after cardiac arrest can help patients recover from shock. About 234 adults who remain unconscious after cardiac arrest and need blood pressure support will be randomly assigned to get either standard …

This study tests whether placing a balloon in the main artery (aorta) during CPR helps restart the heart more often than standard CPR alone. The balloon is inserted through the leg and inflated to block blood flow below the chest, potentially sending more blood to the heart and b…

This study tests whether giving magnesium sulfate soon after a cardiac arrest can protect the brain from damage. Researchers will give 178 patients either magnesium or a saltwater solution within two hours of their heart restarting. The main goal is to see if the treatment is saf…

This study tests whether giving the heart medication amiodarone one cycle earlier than usual during cardiac arrest can improve survival. About 585 adults with a shockable heart rhythm will be enrolled. The goal is to see if this change in timing helps restore a normal heartbeat f…

This trial compares two ways to help patients breathe during a cardiac arrest in the hospital: a supraglottic airway (a tube placed in the throat) versus endotracheal intubation (a tube placed into the windpipe). About 1,060 adults who suffer cardiac arrest while hospitalized wil…

This study tests whether giving a combination of three drugs (epinephrine, vasopressin, and a steroid) during emergency treatment for out-of-hospital cardiac arrest can restart the heart and improve survival compared to the standard drug epinephrine alone. About 1,344 adults in T…

This study tests whether a group of treatments (like controlling body temperature, oxygen levels, blood pressure, and blood sugar) can improve brain function in adults who remain unconscious after a cardiac arrest. About 1,000 participants will be randomly assigned to receive eit…

This study is testing a cloud-based artificial intelligence platform called Willem that analyzes ECG recordings to detect heart rhythm problems and abnormal patterns. Researchers will compare the AI's readings to those of board-certified cardiologists in over 5,300 high-risk card…

This study tests whether a web-based program can improve quality of life for people who survived a cardiac arrest outside the hospital. The program includes educational sessions, brain games, and tips on physical activity and nutrition. Researchers will enroll 106 survivors and m…

This study tests whether advanced MRI scans that map the brain's structural and functional connections can better predict neurological recovery in coma patients after cardiac arrest than standard methods. Researchers will scan 263 adults who remain unconscious at least 72 hours a…

This study observes 50 adult organ donors to measure oxygen levels in the blood when the heart stops during a Maastricht III donation procedure. Researchers take blood samples at key moments to understand how low oxygen gets. The goal is to gather knowledge, not to test a treatme…

This observational study at Brigham and Women's Hospital will use advanced MRI scans to see if brain activity and structure can predict recovery in 50 people who are comatose after a cardiac arrest. Participants will have a special MRI during their standard scan and be followed f…

After a cardiac arrest, many patients remain comatose and are at risk of further brain injury. Doctors currently measure brain oxygen by drawing blood from the jugular vein and sending it to a lab, which takes time. This study tests a special catheter that can measure oxygen leve…

This study explores whether drones can deliver automated external defibrillators (AEDs) to people experiencing cardiac arrest in rural areas faster than traditional emergency responders. Researchers will compare arrival times and see if drone delivery is practical enough to test …

This study looks at whether checking pupils and brain oxygen levels right before starting ECMO can help predict neurological recovery in cardiac arrest patients. Researchers will measure these in 45 adults being evaluated for ECMO, before and after the procedure. The goal is to s…

This study is looking for proteins, metabolites, and platelet changes in the blood that could predict whether a person will survive after receiving ECPR, a machine that takes over heart and lung function during cardiac arrest. Researchers will study blood samples from 130 adults …

This study tests whether a balloon device, called REBOA, can be safely used by emergency teams outside a hospital to improve blood flow in people whose heart has stopped (cardiac arrest). The balloon is inserted into the main artery and inflated to redirect blood to the heart and…

This study follows 700 patients who received ECMO after cardiac arrest to find out what predicts survival and good brain function. Researchers will also check if pre-primed ECMO machines work safely and how patients fare years later. The goal is to help doctors choose the right p…

This study tests whether a serious game (a digital learning tool) can improve critical care nurses' knowledge of targeted temperature management—a cooling treatment used after cardiac arrest. 120 nurses from adult ICUs will be split into two groups: one gets standard lectures, th…

This study looks at whether using a special heart ultrasound (called TEE) during emergencies helps doctors make better decisions and improves patient outcomes. Researchers will track 1,000 critically ill adults in the ER or ICU who receive this test as part of their care. The goa…

This study looks at a better way to predict recovery in people who remain unconscious after a cardiac arrest. Doctors often struggle to know who will wake up, which can lead to early decisions to stop life support. The study will follow 600 patients in the US, Brazil, and Italy, …

This study tests a special rehabilitation program designed to help people who survived a sudden cardiac arrest return to work. The program includes tailored support and is compared to usual care alone. About 214 survivors will take part, and researchers will track their work stat…

This study measures how much air actually reaches the lungs when rescuers give breaths by hand during cardiac arrest. It compares two common airway devices—tracheal tubes and laryngeal mask airways—using a small flow sensor. The 30 participants are already part of a larger trial …

This study looks at how frailty—a state of increased weakness—impacts the results of CPR in patients who need emergency resuscitation. Researchers will track factors like the reason for the emergency, how long CPR lasts, and what equipment is used. The goal is to better understan…

This study compares different scoring systems to predict brain damage in patients admitted to the ICU after cardiac arrest. Researchers will calculate early prognosis scores using clinical and lab values to see which system best identifies patients at risk. The goal is to help do…

This study watches how doctors and nurses perform CPR on children who have had a cardiac arrest. Researchers will check if following American Heart Association guidelines for chest compression depth, rate, and timing leads to better outcomes. Up to 7,000 children across multiple …

This study tests whether a clear plastic box placed over a patient's head during CPR can reduce the spread of viruses like COVID-19 to healthcare workers. Researchers will simulate cardiac arrest scenarios with 240 participants, measuring how well the box works during chest compr…