CARDIAC ARREST

This study tests giving the heart medication amiodarone one cycle earlier than usual during cardiac arrest with a shockable rhythm. Researchers want to see if this speeds up treatment and improves survival. About 585 adults will take part, comparing the new timing to standard car…

This study compares two methods of helping patients breathe during a cardiac arrest in the hospital: a supraglottic airway (a tube placed above the voice box) versus endotracheal intubation (a tube placed into the windpipe). About 1,060 adults who suffer cardiac arrest in the hos…

This study tests whether giving high doses of vitamin C early after a cardiac arrest can help patients recover from shock. About 234 adults who remain unconscious after a cardiac arrest and need medication to maintain blood pressure will be randomly assigned to receive either sta…

This study tests whether a group of treatments—including careful control of body temperature, oxygen, blood pressure, and other factors—can help people who have had a cardiac arrest recover better brain function. About 1,000 adults who are unconscious after resuscitation will be …

This study looks at whether giving a combination of three drugs (epinephrine, vasopressin, and a steroid) to adults who suffer a sudden cardiac arrest outside the hospital can restart their heart better than the standard single drug (epinephrine). About 1,344 participants will be…

This study tests whether placing a balloon in the main artery (aorta) during CPR helps restart the heart more often than standard CPR alone. About 98 adults who have a cardiac arrest in the hospital will take part. The goal is to see if the balloon leads to a sustained heartbeat …

This study tests whether an internet-based program can help people who survived a cardiac arrest and now face problems with memory, mood, or daily life. About 106 participants will use a web app designed to improve their quality of life. The goal is to see if online support can e…

This study tests a special rehabilitation program designed to help people who survived a sudden cardiac arrest outside the hospital return to work. The program includes personalized support and is added to usual care. Researchers will compare how many participants are working 12 …

This study looks at how low oxygen levels get when the heart stops during a specific type of organ donation (Maastricht III). Researchers will monitor 50 adult donors to find the exact oxygen level at the time of cardiac arrest. The goal is to better understand this process, not …

This study looks at whether using a special heart ultrasound (called TEE) during emergencies helps doctors treat critically ill patients better and more safely. Researchers will follow 1,000 adults in the ER or ICU who receive this ultrasound as part of their care. The goal is to…

This study looks at whether placing a balloon in the main artery (aorta) during CPR can help blood flow to the heart and brain in people who have a cardiac arrest outside the hospital. It involves 40 adults aged 18-80 with no major injuries. The goal is to see if the procedure is…

This study is testing a new artificial intelligence (AI) program called Willem that reads electrocardiograms (ECGs) — the test that records your heart's electrical activity. Researchers want to see if the AI can spot dangerous heart rhythms as well as a human heart specialist. Ov…

This study tests whether a serious game (a video game designed for learning) can help ICU nurses better understand targeted temperature management (TTM), a cooling treatment used after cardiac arrest. 120 nurses will be split into two groups: one gets traditional lectures, the ot…

This study looks at blood proteins, metabolites, and platelet changes in 130 adults who had a cardiac arrest and received emergency life support called ECPR. The goal is to find markers that can predict which patients are most likely to survive or recover brain function. By ident…

This study looks at whether a careful, step-by-step approach can better predict recovery in people who remain unconscious after a cardiac arrest. Researchers will follow 600 patients in the US, Brazil, and Italy, using multiple tests at specific times to guide decisions. The goal…

This study measures the actual amount of air delivered to the lungs when rescuers give breaths by hand during cardiac arrest resuscitation. It compares two common airway devices—tracheal tubes and laryngeal mask airways—using a small flow sensor. About 30 adults already in a larg…

This study looks at whether placing a clear plastic box over a patient's head during CPR can reduce the spread of viruses, like COVID-19, to healthcare workers. Researchers will have 240 healthcare providers perform CPR on mannequins, with and without the box, to measure how well…

This study follows 700 people who had a cardiac arrest and were treated with a machine called ECMO. Researchers want to find out which patients are most likely to survive and recover well, and to improve how doctors choose who gets this treatment. They will also check if the ECMO…

This early-stage study looks at whether giving magnesium sulfate soon after a cardiac arrest is safe and practical for protecting the brain. Researchers will enroll 178 adults who had a cardiac arrest and had their heartbeat restored. The main goal is to see if the treatment can …

This study explores whether frailty—a state of increased vulnerability—impacts the results of cardiopulmonary resuscitation (CPR) when a patient's heart or breathing stops. Researchers will track factors like the reason for the emergency, how long CPR lasts, and what equipment is…

This study compares two ways of doing CPR when someone's heart stops outside a hospital: chest compressions only versus compressions plus rescue breaths. About 3,260 adults with witnessed cardiac arrest will take part, and only bystanders with prior CPR training are included. The…

This study compares different scoring systems to predict brain damage in adults admitted to the ICU after cardiac arrest. Researchers will enroll 4,500 patients to see which score best identifies those likely to have poor outcomes. The goal is to help doctors make better treatmen…

This study tests a special catheter that continuously measures oxygen levels in blood leaving the brain of comatose patients after cardiac arrest. Current methods require drawing blood and sending it to a lab, which can only be done every few hours. The new catheter provides real…

This study watches how doctors perform CPR on children whose hearts have stopped. Researchers will check if following specific guidelines for chest compressions leads to better survival. The goal is to find the best CPR techniques to improve outcomes for kids in cardiac arrest.