Could vitamin c save lives after cardiac arrest? new trial investigates
NCT ID NCT05817851
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether giving high-dose vitamin C and thiamine early after cardiac arrest can help patients recover from shock. About 234 adults who remain unconscious after cardiac arrest and need blood pressure support will be randomly assigned to get either standard care or standard care plus high-dose vitamin C for three days. The main goal is to see if vitamin C helps patients come off blood pressure medication faster.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- high-dose vitamin C (ascorbic acid) plus thiamine (vitamin B1)
- What this could lead to
- If it works, this could offer a simple, safe way to reduce shock and organ failure after cardiac arrest, potentially improving survival and brain recovery.
- What could go wrong
- This is an early phase 2 trial with 234 participants, so results are not definitive. High-dose vitamin C may not improve outcomes and could cause side effects like kidney stones.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CH d'Arras
RECRUITINGArras, France
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CH de Melun (GHSIF)
ACTIVE_NOT_RECRUITINGMelun, France
-
CH de Versailles
NOT_YET_RECRUITINGVersailles, France
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CHI Nord-Ardennes
ACTIVE_NOT_RECRUITINGCharleville-Mézières, France
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Centre Hospitalier Béthune
RECRUITINGBéthune, 62408, France
-
Centre Hospitalier Toulon La Seyne sur Mer
RECRUITINGToulon, France
-
Centre Hospitalier Universitaire d'Amiens
ACTIVE_NOT_RECRUITINGAmiens, France
-
Centre Hospitalier Universitaire de LILLE
RECRUITINGLille, France
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Centre Hospitalier de Dieppe
RECRUITINGDieppe, France
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Centre Hospitalier de LENS
RECRUITINGLens, 62307, France
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Centre Hospitalier de Rouen
RECRUITINGRouen, France
-
Centre Hospitalier de Valenciennes
ACTIVE_NOT_RECRUITINGValenciennes, France
-
GHEF Site Marne La Vallée
RECRUITINGJossigny, France
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Hôpital Lariboisière
RECRUITINGParis, 75475, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can cooling after cardiac arrest change how the body burns fuel?
- Double shocks: could two defibrillators save more cardiac arrest patients?
- Could a smarter breathing machine boost survival after cardiac arrest?
- Balloon in the aorta could boost CPR success in cardiac arrest
- Can an education program ease caregiver trauma after a Child's cardiac arrest?
- Brain rescue: dual drug attack on Post-Arrest seizures shows promise