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Can induced hypothermia save more lives after In-Hospital cardiac arrest?

NCT ID NCT07086703

Not yet recruiting Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests whether cooling patients to 33°C (therapeutic hypothermia) improves survival and brain function compared to keeping them at normal body temperature after an in-hospital cardiac arrest. About 788 comatose adults who had a cardiac arrest in the hospital will be randomly assigned to either cooling or controlled normothermia. The main goal is to see if more patients have a good neurological outcome at 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Induced hypothermia (cooling to 33°C)
What this could lead to
If cooling works, it could become a standard treatment to improve survival and brain recovery after in-hospital cardiac arrest.
What could go wrong
This is a large but early-stage trial, and previous studies have shown mixed results. Cooling may not improve outcomes and could cause side effects like infection or heart rhythm problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiac arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC ARREST

Contacts and locations

Locations

  • APHM - Hôpital Nord

    Marseille, 13015, France

  • APHP - Hôpital Ambroise Paré

    Paris, 92200, France

  • APHP- Hôpital Cochin

    Paris, 75679 cedex 14, France

  • APHP-Hôpital Saint-Antoine

    Paris, 75517, France

  • CH Brocéliande Atlantique

    Vannes, 56017 cedex 1, France

  • CH Dubois Brive

    Brive-la-Gaillarde, 19312 cedex, France

  • CH Public du Cotentin

    Cherbourg, 50102, France

  • CH d'Angoulême

    Angoulême, 16000, France

  • CH de Roanne

    Roanne, France

  • CH de Rodez

    Rodez, 12027, France

  • CHD Vendée

    La Roche-sur-Yon, 85025 Cedex, France

  • CHR d'Orléans

    Orléans, 45100, France

  • CHRU de Strasbourg

    Strasbourg, 67091 cedex, France

  • CHRU de Tours

    Tours, 37044 Cedex 9, France

  • CHRU- Hôpital Roger Salengro

    Lille, 59307 cedex, France

  • CHU Bocage

    Dijon, 77908, France

  • CHU Charleroi

    Charleroi, Belgium

  • CHU Clermont-Ferrand

    Clermont-Ferrand, 63003 cedex 1, France

  • CHU Dupuytren

    Limoges, 87042 Cedex 1, France

  • CHU Les Abymes

    Pointe-à-Pitre, La Guadeloupe, 97110, Guadeloupe

  • CHU de Caen

    Caen, 14033, France

  • CHU de Nantes

    Nantes, France

  • Clinique Saint-PIerre

    Ottignies, Belgium

  • Hôpital André Mignot

    Le Chesnay, 78150, France

  • Hôpital Edouard Herriot

    Lyon, 69437, France

  • Hôpital Erasme

    Brussels, Belgium

  • Hôpital Privé Jacques Cartier

    Massy, 91300, France

  • Hôpital Sainte-Musse

    Toulon, 83100, France

  • Hôpital Simone Veil

    Cannes, 06414 cedex, France

  • Hôpital Universitaire de Bruxelles

    Jette, Belgium

  • Hôpital Universitaire de Gand

    Ghent, Belgium

  • Hôpital de l'Archet

    Nice, 06200, France

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