Nantes University Hospital

This study tests whether belatacept, a drug that suppresses the immune system without harming the kidneys, can help heart transplant patients at high risk of chronic kidney disease. About 25 participants will receive belatacept along with reduced doses of standard immunosuppressa…

This study is for people who have had a stem cell transplant for blood cancer and are at high risk of serious fungal infections. The standard preventive drug may not work well enough anymore, so researchers are testing a stronger drug called posaconazole. They will check the drug…

This study tests a new radioactive drug (177Lu-PentixaTher) for people with acute leukemia that has come back or not responded to other treatments. The drug seeks out and delivers radiation to leukemia cells that have a specific marker (CXCR4). The main goals are to find the safe…

This early-phase study tests whether a patient's own immune cells, called CD8+ regulatory T cells, can be grown in a lab and then given back to them after a kidney transplant. The goal is to see if this cell therapy is safe and might allow patients to take fewer standard anti-rej…

This study tests a newer pacing method called left bundle branch area pacing against standard pacing for people who develop heart block after a TAVI procedure. About 266 participants will be randomly assigned to one of the two pacing types. The goal is to see if the newer method …

This study tests a drug called romiplostim given before heart surgery to people with low platelet counts. The goal is to see if it can raise platelet levels enough to make surgery safer and reduce the need for blood transfusions. About 136 adults will take part, and half will get…

This study tests whether a narrow-spectrum antibiotic (amoxicillin alone) works as well as a broader one (amoxicillin/clavulanate) for pneumonia in people aged 65 and older who are hospitalized but not in intensive care. The goal is to reduce unnecessary use of strong antibiotics…

This study tests two different chemotherapy conditioning plans combined with a single drug (cyclophosphamide and methotrexate) to prevent graft-versus-host disease (GVHD) after a stem cell transplant. About 82 adults with blood cancer who have a matched donor will participate. Th…

This study tests whether giving the steroid dexamethasone early after a severe burn can lower the risk of major complications like lung or kidney failure and death. About 478 adults with burns covering at least 20% of their body and who need a breathing tube will take part. The g…

This study tests a new treatment for people with blood cancer who have had a stem cell transplant. The treatment uses specially designed immune cells (T cells) that can recognize and kill cancer cells that share a specific marker (HLA-DPB1*04:01). The goal is to see if this cell …

This study compares two drug combinations given before a stem cell transplant for adults with acute myeloid leukemia (AML) in remission. The goal is to see if using clofarabine plus busulfan leads to better 2-year survival than the standard fludarabine plus busulfan. About 302 pa…

This study looks at whether it is safe to wait for lab results before giving antibiotics to patients on breathing machines who may have pneumonia. About 686 adults will be randomly assigned to get antibiotics immediately or only after the infection is confirmed. The goal is to se…

This study tests whether giving a concentrated salt solution (hypertonic saline) early after a severe traumatic brain injury can help more people survive and regain independence in daily activities. About 760 patients in intensive care will receive either the salt solution or sta…

This study aims to see if a simple finger-prick (capillary) blood test can accurately measure carbon monoxide levels compared to standard blood draws from a vein or artery. Researchers will enroll 120 adults in emergency rooms who show symptoms like headache or nausea and have a …

This study tests a new brain monitoring tool for babies under 2 in intensive care. Many seizures in these infants are invisible to caregivers, and current monitors can miss them. The new approach combines a simplified brain wave display with expert review to improve detection and…

This study looks at whether emergency doctors can use a quick bedside ultrasound to rule out a blocked small intestine. About 667 adults with belly pain and a low or medium chance of blockage will get an ultrasound first, then a CT scan to confirm. If ultrasound works well, many …

This study tests a new type of PET/CT scan that uses a special tracer to see if it can find liver cancer more accurately. About 40 adults with newly diagnosed or suspected returning liver cancer will get this scan. The goal is to improve how doctors detect and monitor the disease…

This study compares 3D cone beam CT scans to standard panoramic X-rays for detecting hidden dental infections in 170 patients hospitalized for infective endocarditis, a serious heart infection. The goal is to see if the 3D approach finds more problem areas, leading to better oral…

This study tests a new way of doing PET scans that uses two different tracers at the same time to get a more complete picture of liver and pancreatic tumors. Researchers want to see if this "multiplexed" method finds more tumors and gives clearer information than the standard sin…

This study is testing a new radioactive tracer called 89Zr-TLX250 to see if it can better detect liver cancers (hepatocellular carcinoma and intrahepatic cholangiocarcinoma) and pancreatic neuroendocrine tumors on PET-CT scans. About 60 adults with these cancers will receive the …

This study tests whether injecting botulinum toxin (Botox) into the uterine muscle can relieve severe period pain in women who haven't gotten relief from standard treatments like painkillers or hormones. About 222 women will receive either Botox or a placebo injection during a hy…

This study tests whether a high-dose capsaicin patch (the stuff that makes chili peppers hot) can relieve chronic tailbone pain. About 188 adults with pain lasting over 3 months will receive either the active patch or a low-dose placebo patch. The main goal is to see if more peop…

This study looks at whether low-risk pregnant women can safely go home after starting labor induction with a balloon catheter, instead of staying in the hospital. About 258 women will be randomly assigned to either go home or stay in the hospital. The goal is to see if going home…

This study tests a new, playful program to help children aged 3 to 6 complete an MRI scan without needing sedation or general anesthesia. The program uses four themed modules (like a tunnel and loud noises) to prepare kids in a fun, low-stress way. If successful, it could reduce …

This study tests whether eating a diet low in polyamines (natural compounds found in many foods) for a week before and after major abdominal surgery can lower pain levels. About 278 adults having a second abdominal surgery will be randomly assigned to either the special diet or t…

This study tests whether people with new shoulder pain from rotator cuff tendinopathy recover faster with monthly doctor visits for 3 months compared to standard care (one visit at 3 months). 156 adults aged 18-65 with pain for less than 6 months will be randomly assigned to eith…

This study looks at two different exercise programs done before ACL surgery to see which one helps people regain knee strength and muscle size more effectively. About 84 adults with a first-time ACL injury will take part in a 9-week program. One group does focused strength traini…

This study tests three different sleep medicines (propofol, ketamine, and a mix of both) to find which one works best for placing a breathing tube quickly and safely in people having emergency surgery. About 1,200 adults at risk of stomach contents entering the lungs will take pa…

This study tests whether adding a cognitive remediation (brain training) program to standard ADHD medication helps adults with both ADHD and addiction improve their daily functioning. Researchers will compare the brain training program to a control program in 248 participants. Th…

This study aims to better predict the risk of sudden cardiac death or heart failure in people with inherited heart conditions. Researchers will use artificial intelligence to analyze medical data from 1,000 participants, including heart tests, genetic information, and imaging. Th…

This study looks at how low oxygen levels get when the heart stops during a specific type of organ donation (Maastricht III). Researchers will monitor 50 adult donors to find the exact oxygen level at the time of cardiac arrest. The goal is to better understand this process, not …

This study looks at how people with advanced cancer feel about stopping medicines they may no longer need. Many patients take multiple drugs, which can cause side effects and lower quality of life. Researchers will interview about 325 patients and use questionnaires to understand…

This study will follow 819 children under 2 years old who have medium to giant congenital nevi (birthmarks). Researchers want to learn how often these children have brain development issues, the true risk of melanoma, and the emotional impact on families. The goal is to create cl…

This study is creating a large collection of medical data and biological samples from 1,100 people with brain aneurysms. The goal is to better understand which aneurysms are likely to rupture by analyzing genetics, imaging, and clinical information. This research does not test a …

This study looks at whether a 30-day remote monitoring program can reduce hospital readmissions after colorectal surgery. About 362 adults who had or will have colorectal surgery will be randomly assigned to either the remote monitoring group or standard discharge. The main goal …

This study aims to validate a French version of a questionnaire that measures quality of life in people with primary hyperparathyroidism, a condition that can cause fatigue, bone pain, and mood changes. Researchers will enroll 548 adults, both before and after surgery, to see if …

This study follows 1,000 adults with small, unruptured brain aneurysms (3–7 mm) for three years. Researchers use MRI to check for a specific sign called wall enhancement, which may help predict which aneurysms are likely to grow. The goal is to create a safer, more personalized f…

This study collects blood, bone marrow, or lymph node samples from 60 people with chronic lymphocytic leukemia (CLL) who are taking or about to take BTK degraders. Researchers will analyze the samples to find out why some patients stop responding to these drugs. The goal is to be…

This study aims to understand why multiple sclerosis (MS) is mild in some people but severe and disabling in others. Researchers will compare blood cells from 130 people with aggressive MS, non-aggressive MS, and healthy volunteers. They will use advanced genetic and cell analysi…

This study looks at whether certain proteins in the blood (called cytokines) can help predict how well patients with acute myeloid leukemia, high-risk myelodysplastic syndrome, or chronic myelomonocytic leukemia will do on a milder type of chemotherapy (azacytidine). Researchers …

This study looks at how walking patterns and MRI brain scans can help explain walking difficulties in people with multiple sclerosis (MS). About 100 adults with MS will wear a small device while walking and have an MRI scan. The goal is to better understand walking problems, not …

This study looks at how eating more plant-based foods during pregnancy might affect the health of the mother and newborn. Researchers will track the diets of 670 pregnant women and measure things like blood fats and pregnancy outcomes. The goal is to understand if a plant-heavy d…

This study looks at 30 adults with idiopathic nephrotic syndrome, a kidney condition that can lead to kidney failure. Researchers will analyze blood immune cells and bacteria from stool and urine samples to see if changes in gut bacteria are linked to immune problems and disease …

This study looks at whether a certain type of immune cell, boosted by a gut bacterium, can help prevent the body from rejecting a new kidney. Researchers will study blood samples from 15 kidney transplant patients and their donors. The goal is to understand how these cells work, …

This study aims to find how common hidden heart artery blockages are in people with familial hypercholesterolemia (inherited high cholesterol) who have no symptoms. Researchers will use a special CT scan to look for significant blockages in 600 participants. The goal is to better…

This study follows 200 acne patients at Nantes University Hospital to learn what factors affect treatment success and how acne impacts quality of life. Researchers will collect skin samples and track patients' care and costs. No new treatment is being tested; the goal is to gathe…

This study looks at children who had severe bacterial infections requiring intensive care between 2015 and 2018 in France. Researchers want to understand why some children get much sicker than others by analyzing their genes, immune systems, and medical history. The goal is to fi…

This study tests whether a connected watch can better detect returning atrial fibrillation (an irregular heartbeat) in 106 adults who had heart surgery and developed a temporary irregular rhythm. Participants will wear the watch for 12 months, and doctors will compare the watch's…

This study is collecting information and biological samples from 730 adults newly diagnosed with lung cancer. Researchers want to see how patients respond to treatments in everyday medical practice, not just in strict clinical trials. The goal is to better understand the disease …

This study watches how adults recover after heart or chest surgery if they also have COVID-19. It measures heart and organ problems after surgery. No new treatments are tested; the goal is to learn and improve care. About 350 people will take part.

This study follows 450 babies born with serious heart defects to detect developmental delays as early as 6 months old. Researchers want to understand why over half of these children later face challenges with learning, attention, or behavior. The goal is to find early signs and r…

This study looks at whether the antibiotic clindamycin can be used instead of vancomycin to prevent infections in people having heart surgery with a heart-lung machine. Many patients are allergic to the usual antibiotics, and vancomycin can be hard to use safely. The goal is to m…

This study looks at 1,206 children aged 3 to 11 who had heart surgery early in life. The goal is to find out how many develop learning, thinking, or behavior problems, and to search for genetic clues that might link heart and brain development. No new treatment is tested; instead…

This study is creating a group of 465 people with hidrosadenitis to learn about the different forms of the disease. Researchers will track patients' health history, symptoms, and lifestyle to find patterns. No new treatment is being tested; the goal is to better understand the di…

This study looks at whether eating sunflower oil rich in oleic acid (a healthy fat) can change how fat cells handle cholesterol in women with obesity. About 40 women scheduled for weight-loss surgery will take either the special oil or regular sunflower oil for 13 weeks. Research…

This study looks at whether giving routine heart ultrasounds to nursing home residents can help catch heart problems early and reduce emergency hospital visits. About 1,050 residents will take part. The goal is to see if this screening is practical and effective in a nursing home…

This study tests whether a personalized program of nutrition and physical therapy, started early in the ICU and continued at home, helps people recover better after being on a breathing machine and heart-support medications. About 830 adults will be randomly assigned to either th…

This study looks at wastewater from nursing homes to see if it can help predict how many residents carry antibiotic-resistant bacteria. Researchers will collect stool samples from about 1,600 elderly residents and compare that to bacteria levels found in the facility's wastewater…

This study aims to find genetic changes that may increase the risk of sudden infant death syndrome (SIDS). Researchers will analyze the complete DNA of 650 infants who died from SIDS and both of their parents. By comparing these family trios, they hope to identify new genes or mu…

This study looks at babies under 6 months old who need heart surgery. During surgery, the thymus gland is often removed completely to help the surgeon reach the heart. The thymus is important for building a strong immune system early in life. Researchers want to see if removing o…

This study compares two methods for inserting a breathing tube in emergency situations outside the hospital: using a bougie (a flexible guide) versus the tube alone. The goal is to see which approach helps paramedics succeed on the first attempt, reducing risks like low oxygen or…

This study follows children born very early (before 35 weeks) to see if they have a higher risk of insulin resistance as they grow up. Researchers will measure body fat, blood sugar, and other health markers in kids aged 8 to 14. The goal is to understand how early birth affects …

This study is looking at 80 people with a genetic heart condition called arrhythmogenic cardiomyopathy, which can cause sudden death or heart failure. Researchers want to see if a special PET-MRI scan can detect inflammation in the heart muscle that might affect how the disease p…

This study follows 403 adults with primary hyperparathyroidism to see how parathyroid surgery affects their heart, kidneys, bones, and overall quality of life over five years. Participants give blood samples and undergo check-ups at regular visits. The goal is to better understan…

This study looks at whether training nursing home caregivers in oral hygiene can improve the oral health-related quality of life for elderly residents. Researchers will train staff and then measure changes in residents' well-being and caregivers' anxiety levels after 6 months. Th…

This study looks at how spinal cord injury changes the nerves and lining of the gut. Researchers will take small tissue samples from the colon of 40 people with spinal cord injury during a routine colonoscopy. The goal is to understand these gut changes and find new ways to treat…

This study aims to create an artificial intelligence tool that analyzes photos of skin damage around a melanoma scar to predict whether a patient will respond to anti-PD-1 immunotherapy. Researchers will enroll 700 adults with advanced melanoma or other skin cancers. The goal is …

This study looks at whether bariatric surgery can slow or reverse biological aging in people with obesity. Researchers will measure changes in blood markers, fat cells, and gut bacteria before and after surgery. The goal is to understand how weight-loss surgery affects the body's…

This study looks at how indoor and outdoor air pollution affects people with asthma. Researchers will place sensors in 30 patients' homes to measure pollutants like fine particles and chemicals. The goal is to see if higher pollution levels are linked to more asthma attacks. Part…

This study is following over 2,700 people seeking help for behavioral addictions (like gambling or gaming) at a hospital in France. The goal is to learn what factors affect how these addictions change over time and how well people stick with their treatment. Researchers will look…

This study looks at how well the right side of the heart works in people with severe heart valve disease. Researchers will use a thin tube (catheter) to get precise measurements and compare them with non-invasive imaging tests like echocardiograms. The goal is to see if simpler t…

This study looks at a breathing technique called high-frequency jet ventilation used during a minimally invasive procedure to destroy solid tumors. The goal is to see if setting the machine's pressure based on a patient's height leads to better breathing and oxygen levels compare…

This study gathers information from 80 adults who have both ADHD and an addiction. Over two visits in one year, researchers will collect data on symptoms, daily functioning, and treatment. The goal is to better understand how these conditions interact and improve future care.

This study looks at how gut bacteria might influence fear of weight gain and changes in body fat in women with anorexia nervosa. Researchers will collect stool and blood samples from 60 women admitted for refeeding. The goal is to find patterns in gut microbes that could help imp…