Could a common numbing drug cut opioid needs in sickle cell emergencies?

NCT ID NCT07274254

Recruiting now Symptom relief Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study tests whether adding lidocaine, a numbing medicine, to standard pain treatment can lower the amount of strong opioids needed during severe sickle cell pain crises. About 104 adults with sickle cell disease who are in the intensive care unit for a pain crisis will take part. The goal is to see if lidocaine helps control pain while reducing opioid use and side effects.

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Conditions

The condition(s) this trial relates to.

acute chest syndrome agnosia sickle cell disease Vaso-Occlusive Crises

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VASO-OCCLUSIVE PAIN EPISODE IN SICKLE CELL DISEASE

Contacts and locations

Locations

CHRU Tours - Hôpital Bretonneau
NOT_YET_RECRUITING

Tours, France
CHU Bordeaux
NOT_YET_RECRUITING

Bordeaux, France
CHU Guadeloupe
NOT_YET_RECRUITING

Les Abymes, Guadeloupe
CHU La Timone
NOT_YET_RECRUITING

Marseille, France
CHU Lille
NOT_YET_RECRUITING

Lille, France
CHU Orléans
NOT_YET_RECRUITING

Orléans, France
CHU Poitiers
NOT_YET_RECRUITING

Poitiers, France
CHU Rouen
NOT_YET_RECRUITING

Rouen, France
CHU de Nantes
RECRUITING

Nantes, France
Hôpital Tenon APHP
NOT_YET_RECRUITING

Paris, France
Oncopole Toulouse
NOT_YET_RECRUITING

Toulouse, France

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