New drug aims to cut sickle cell pain episodes
NCT ID NCT04935879
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a drug called inclacumab in about 240 people with sickle cell disease who experience painful vaso-occlusive crises. Participants received either inclacumab or a placebo by IV infusion. The main goal was to see if inclacumab could reduce the number of these painful episodes over 48 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- inclacumab (a P-selectin inhibitor given by IV infusion)
- What this could lead to
- If it works, inclacumab could become a new treatment to reduce the frequency of painful crises in people with sickle cell disease.
- What could go wrong
- This is a completed Phase 3 trial, but results are not yet fully published. The drug may not show a meaningful benefit over placebo, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Acibadem Adana Hastanesi Cocuk Hematoloji Onkoloji
Adana, 01130, Turkey (Türkiye)
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Ahmadu Bello University Teaching Hospital
Zaria, Kaduna State, 1100011, Nigeria
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AinShams University Hospital
Cairo, 11588, Egypt
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American University of Beirut Medical Center
Hamra, Beirut, Lebanon
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Aminu Kano Teaching Hospital
Kano, 700233, Nigeria
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Arkansas Children's Hospital
Little Rock, Arkansas, 72202, United States
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Barau Dikko Teaching Hospital/Kaduna State University
Kaduna, 800212, Nigeria
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Baskent University Hospital
Adana, Yuregir, 01250, Turkey (Türkiye)
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CEPEC-Centro de Pesquisa Clinica
São Paulo, 08270-120, Brazil
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Casa de Saúde Santa Marcelina
São Paulo, 08270-070, Brazil
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Clinica de la Costa Ltda.
Barranquilla, Atlántico, 080020, Colombia
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DUMC Investigational Drug Services Pharmacy
Durham, North Carolina, 27710, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Dana-Farber Cancer Institute IDS Pharmacy
Boston, Massachusetts, 02215, United States
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Department of Pediatrics, College of Medicine, Lagos University Teaching Hospital
Lagos, 100254, Nigeria
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Duke University Medical Center
Durham, North Carolina, 27705, United States
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Faculty of Medicine Cairo University
Cairo, 11562, Egypt
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Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, São Paulo, 15090-000, Brazil
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Gertrude's Children Hospital
Nairobi, 00100, Kenya
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Hospital Das Clinicas da Faculdade de Medicina de Ribeirão Preto - USP
Ribeirão Preto, São Paulo, 14051-140, Brazil
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Hospital Pharmacy Services- Investigational Drug Services
Chicago, Illinois, 60612, United States
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Hospital Samaritano Higienópolis/Esho Empresa De Servicos Hospitalares S.A
São Paulo, 01232-010, Brazil
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Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Hôpital Henri Mondor
Créteil, 94010, France
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Institut Universitaire du Cancer de Toulouse-Oncopole
Toulouse, 31059, France
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Instituto D'Or de Pesquisa e Ensino - Hospital São Rafael
Salvador, Estado de Bahia, 41253-190, Brazil
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Instituto Estadual de Hematologia Arthur Siqueira Cavalcanti - HEMORIO
Rio de Janeiro, 20211-030, Brazil
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International Cancer Institute
Eldoret, 30100, Kenya
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Jacobi Medical Center
The Bronx, New York, 10461, United States
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KEMRI/CRDR, Siaya, KEMRI Clinical Research Annex
Kisumu, Siaya County, 40600, Kenya
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Kenya Medical Research Institute- Center for Respiratory Disease Research
Nairobi, 00100, Kenya
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McGovern Medical School/Health Science Center Houston
Houston, Texas, 77030, United States
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Memorial Hermann - TMC Investigational Drugs, IDS Pharmacy
Houston, Texas, 77030, United States
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Memorial Hermann Hospital, Texas Medical Center - Clinical Research Unit (CRU)
Houston, Texas, 77030, United States
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Mersin Universitesi Tip Fakultesi Saglik Arastirma ve Uygulama Merkezi Hastanesi
Yenişehir, Mersin, 33343, Turkey (Türkiye)
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Multihemo Serviços Médicos S/A
Recife, Pernambuco, 50070-460, Brazil
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NIMR-Mbeya Medical Research Center
Mbeya, Tanzania
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National Hospital Abuja
Abuja, Federal Capital Territory, 900211, Nigeria
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Nini Hospital
Tripoli, North Lebanon, Lebanon
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Prince Mohammed bin Nasser Hospital
Jizan, Southern, 82943, Saudi Arabia
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Rush University Medical Center
Chicago, Illinois, 60612, United States
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Rush University Medical Center Investigator Pharmacy
Chicago, Illinois, 60612, United States
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Sociedad de Oncologia y hematologia del Cesar S.A.S.
Valledupar, Cesar Department, 200001, Colombia
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Strathmore University Medical Center - Center for Research in Therapeutic Sciences(CREATES)
Nairobi, 00200, Kenya
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Sultan َQaboos University Hospital
Muscat, 123, Oman
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UC Irvine Health
Orange, California, 92868, United States
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UCI Center for clinical research
Orange, California, 92868, United States
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UT Physicians Comprehensive Sickle Cell Clinic
Houston, Texas, 77030, United States
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Uconn Health/Uconn John Dempsey Hospital/Neag Comprehensive Cancer Center/New England Sickle Cell
Farmington, Connecticut, 06030, United States
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University of Abuja Teaching Hospital
Gwagwalada, Federal Capital Territory, 902101, Nigeria
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University of Calabar Teaching Hospital
Calabar, Cross River State, 540242, Nigeria
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University of Illinois Clinical Research Center (CRC)
Chicago, Illinois, 60612, United States
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University of Illinois Hospital and Health Sciences System(UI Health)
Chicago, Illinois, 60612, United States
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University of Michigan Hospitals - Michigan Medicine
Ann Arbor, Michigan, 48109, United States
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University of Nigeria Teaching Hospital
Enugu, 460000, Nigeria
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University of South Alabama Children's and Women's Hospital
Mobile, Alabama, 36604, United States
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University of South Alabama Mitchell Cancer Institute
Mobile, Alabama, 36604, United States
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University of South Alabama Strada Patient Care Center
Mobile, Alabama, 36604, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can Co-Designed support help parents embrace sickle cell care?
- Can community hospitals in zambia master severe disease care?
- A Pocket-Sized coach for sickle cell: can an app turn Pill-Taking into a habit?
- Can a phone app keep teens on track with sickle cell treatment?
- A common amino acid may calm sickle cell pain crises — a trial puts it to the test
- A drug that protects the liver may make stem cell transplants safer for children with sickle cell disease