Nantes University Hospital

This trial was designed to test a milder conditioning regimen using a radioactive antibody (90Y-Epratuzumab) followed by chemotherapy and a stem cell transplant for adults with CD22-positive B-cell acute lymphoblastic leukemia. The goal was to find the safest dose that still cont…

This study tests a combination of three oral drugs—ixazomib, iberdomide, and dexamethasone—in patients over 70 with multiple myeloma that has returned after initial treatment. The goal is to see how many patients achieve a very good partial response or better. 75 participants wil…

This phase 2 trial tests whether using teclistamab or talquetamab (immune cell redirectors) after initial treatment can improve outcomes for newly diagnosed multiple myeloma. 103 patients receive either teclistamab with lenalidomide or teclistamab with talquetamab, depending on t…

This study tests whether a fecal microbiota transplant (FMT) from a healthy donor can delay or prevent pouchitis, a common complication after ulcerative colitis patients have their colon removed and a pouch created. About 42 adults who have had this surgery and have had pouchitis…

This study looks at whether giving extra oxygen through a nasal tube during hospital stay can lower the chance of wound infections and skin issues after ankle surgery. It involves 200 adults who are at higher risk due to conditions like diabetes or smoking. Half receive oxygen, h…

This study tests whether a device called MitraClip, which repairs the mitral valve through a small tube inserted in a blood vessel, works as well as traditional open-heart surgery for people with severe mitral regurgitation who are at high risk for surgery. About 330 participants…

This study looks at whether people with atopic dermatitis (eczema) that has been well-controlled for at least six months can safely take dupilumab less often. About 256 teens and adults will either stick with their usual every-two-week injection or gradually space out doses. The …

This study looks at whether a new radioactive tracer called PentixaFor can find multiple myeloma lesions more accurately than the standard FDG tracer during PET scans. About 45 adults with symptomatic multiple myeloma, either newly diagnosed or in relapse, will receive both types…

This study is testing whether a special heart scan (dynamic SPECT) can accurately detect remaining blockages in heart arteries after a heart attack, compared to the current standard invasive procedure (FFR). Sixty adults with multiple blocked arteries will receive both tests one …

This pilot study tests whether one-on-one peer support sessions can help people with relapsing-remitting multiple sclerosis stay on their prescribed medications. Sixty adults will be randomly assigned to receive either standard care or three hour-long sessions with a trained peer…

This study planned to check whether vitamin D levels affect pregnancy rates in women undergoing IVF. It was withdrawn before enrolling any participants, so no data or conclusions are available. The idea was to measure vitamin D in blood samples and compare it to IVF outcomes like…

This study aims to describe French gamblers who are at risk or have a pathological gambling problem. Researchers will collect information on their gambling history, personality, and other health issues. The goal is to compare this data with studies from other countries and to tes…

This study aimed to see if Alzheimer's disease affects the nerves in the gut, similar to what happens in Parkinson's disease. Researchers planned to take extra colon biopsies during routine colonoscopies from people with Alzheimer's, Parkinson's, and healthy individuals to compar…

This study was designed to look at how tiny energy-producing parts of cells (mitochondria) in the liver might be linked to fatty liver disease in people with obesity who were scheduled for weight-loss surgery. Researchers planned to take small liver samples during surgery to stud…

This study aimed to see if the antibiotic doxycycline could protect people from severe COVID-19. Researchers planned to analyze health records of patients who took doxycycline for acne during the pandemic. However, the study was withdrawn before enrolling any participants, so no …

This study looks at how a measure called the hemoglobin glycation index (HGI) changes over time in 750 adults with diabetes who use continuous glucose monitors. HGI compares lab-measured blood sugar levels with estimated levels from a glucose monitor. Researchers will collect dat…

This study aims to find new genes that cause very low cholesterol levels (a condition called FHBL). Researchers are recruiting 435 people with low cholesterol and their family members to analyze their DNA. The goal is to discover new targets for understanding and potentially mana…

This study looks at how social factors like income, education, and lifestyle might influence the risk of a brain aneurysm bursting. Researchers will analyze data from 1,800 patients using artificial intelligence to find patterns. The goal is to improve risk prediction and help pr…

This study is looking for new genes that may cause certain types of congenital heart disease, specifically transposition of the great arteries. Researchers will collect DNA from up to 300 children with these heart defects and their parents to find genetic changes. The goal is to …