Nantes University Hospital

This study tests whether a fecal microbiota transplant (FMT) from a healthy donor can delay or prevent recurrent pouchitis in people with ulcerative colitis who have had ileal pouch-anal anastomosis surgery. About 42 adults with chronic pouchitis will receive either FMT or a sham…

This study tests whether people with controlled atopic dermatitis (eczema) can safely take dupilumab less often without losing control of their disease. About 256 teens and adults who have been on the standard every-2-week dose for at least a year will either stay on that schedul…

This study tests whether a minimally invasive clip repair (MitraClip) is as effective as open-heart surgery for people with severe mitral regurgitation who are at high risk for surgery. About 330 participants will be randomly assigned to one of the two treatments and followed for…

This study looks at whether giving extra oxygen through the nose can lower the chance of wound problems after ankle fracture surgery. It includes 200 patients who are at higher risk due to issues like diabetes, smoking, or complex fractures. Half will get oxygen therapy while in …

This study tests whether adding T-cell redirecting drugs (teclistamab and talquetamab) to standard therapy can eliminate remaining cancer cells in people with newly diagnosed multiple myeloma. About 103 adults under 66 will receive one of two drug combinations based on their mini…

This study tests whether a special heart scan (dynamic SPECT) can accurately detect leftover blockages in heart attack survivors, compared to the current standard invasive test (FFR). About 60 adults with multiple blocked arteries will get both tests. If the scan works well, it c…

This study is testing whether a new radioactive tracer called PentixaFor can find multiple myeloma lesions more accurately than the standard FDG tracer during PET scans. Researchers will compare the two tracers in 45 patients who are either starting first-line treatment or have r…

This study tests whether a natural substance from spirulina (phycocyanin) can reduce nerve damage caused by oxaliplatin chemotherapy in people with advanced gastrointestinal cancers. About 110 participants will receive either phycocyanin or a placebo during their chemo. The goal …

This study aims to find new genes that cause very low cholesterol levels (a condition called FHBL). Researchers are recruiting 435 people with FHBL and their family members to collect DNA and urine samples. By analyzing the genetic makeup of these families, they hope to discover …

This study aims to find new genes linked to two specific types of congenital heart defects (transposition of the great arteries and congenitally corrected transposition). Researchers will analyze DNA from 300 children with these conditions and their parents. The goal is to improv…

This study looks at how a measure called the Hemoglobin Glycation Index (HGI) changes over time in people with diabetes. Researchers will track 750 adults who already use continuous glucose monitors. The goal is to better understand this blood sugar marker, not to test a new trea…

This study looks at how social factors like income, housing, and lifestyle affect the risk of a brain aneurysm bursting. Researchers will use artificial intelligence to analyze health records from 1,800 adults. The goal is to better predict who is at risk and improve prevention.