Nantes University Hospital

This study looks back at medical records to see how well a slow-release steroid implant works for adults with a chronic inflammatory eye disease. Researchers will analyze data from about 100 patients over three years to understand how often and how severe their eye inflammation f…

This study is testing if the antibiotic clindamycin can safely and effectively prevent surgical site infections during major heart surgery that uses a heart-lung machine. It focuses on patients who are allergic to the standard antibiotics used for this purpose. Researchers will m…

This study compares two standard methods for repairing skin after melanoma removal surgery. Researchers want to see if using a perforator flap (moving nearby healthy skin) leads to faster healing and better quality of life compared to a traditional skin graft (taking skin from an…

This study tests a new surgical technique performed during planned heart surgery to control atrial fibrillation (AF), a common irregular heartbeat that increases stroke risk. Researchers will use a special device to create scar tissue around heart areas that trigger AF, aiming to…

This early-stage study is testing whether adding the drug tocilizumab to a standard two-drug chemotherapy (venetoclax and azacitidine) is safe and tolerable for adults with acute myeloid leukemia (AML) who cannot receive the most intensive treatments. The main goal is to find the…

This study is testing a new home monitoring system for babies and young children recovering from heart surgery. It uses special sensors to track the child's health at home and sends alerts to medical teams if problems are detected. The goal is to reduce serious complications and …

This study is testing if a simpler antibiotic treatment works as well as the current standard for serious infections on artificial heart valves. The standard treatment includes a drug called rifampin, which can cause significant side effects and interact with other medications. R…

This study is looking back at medical records to see if switching patients with a severe form of wet age-related macular degeneration (AMD) to a new, higher-dose version of an existing eye injection (aflibercept 8 mg) helps. The main goal is to see if patients can go longer betwe…

This study is testing whether adding a special brain training program helps people being treated for alcohol use disorder. The program aims to improve thinking skills, self-awareness, and the feeling of being capable of managing recovery. Researchers will compare outcomes for 130…

This study is testing if a daily eating schedule can help reduce fat in the liver. People with obesity and fatty liver disease will try eating all their food within an 8-hour window each day for 12 weeks, without counting calories. Researchers will use MRI scans to see if this ti…

This study aims to see how well children adapt to and tolerate a specific type of spectacle lens designed to slow the progression of nearsightedness (myopia). It will involve 50 children, aged 6 to 16, whose eyesight is getting worse. The main goal is to understand if the glasses…

This study tests whether a brain stimulation treatment called tDCS works as well when done at home compared to in a hospital. Researchers will enroll 66 adults with moderate to severe depression to see if home treatment reduces symptoms as effectively after 6 weeks. The goal is t…

This study will follow 375 patients who receive large, modular bone implants to replace major bone loss, often from cancer or severe injury. The main goal is to see how well these implants last over five years without needing replacement surgery. Researchers will also track how w…

This study compares two approaches for starting labor in low-risk pregnant women: going home versus staying in the hospital after a small balloon device is placed to help the cervix prepare. Researchers want to see if going home is safe, how long labor takes, how satisfied mother…

This study is testing if a drug called romiplostim can safely increase platelet counts in adults with low platelets before they undergo major heart surgery. The goal is to help these high-risk patients have the life-saving surgery they need with a lower chance of dangerous bleedi…

This study aims to see if giving a concentrated saltwater (saline) solution early and continuously through an IV can help people survive and live more independently after a severe traumatic brain injury. It will involve 760 patients in intensive care who are at high risk of dange…

This study aims to find out if cooling patients to 33°C (91.4°F) after their heart stops in the hospital leads to better survival with good brain function, compared to carefully keeping a normal body temperature. It will involve 788 adult patients who are in a coma after their he…

This study is testing a new home telemonitoring program called EPOCA for patients recovering from digestive surgeries like colorectal or bariatric procedures. It aims to see if using connected devices and remote support from a medical team can safely allow patients to leave the h…

This pilot study will test whether combining psilocybin (a psychedelic compound) with psychotherapy can help people with gambling disorder. Researchers will enroll 30 adults to assess if the treatment approach is feasible and safe, while gathering early data on whether it reduces…

This study is testing if a specific strength-training program before ACL knee surgery leads to better recovery than traditional pre-surgery exercises. About 84 adults waiting for surgery will be randomly assigned to follow either the new strength program or the usual exercise pla…

This study aims to see if a standard heart test (a 12-lead ECG) can be used to determine if a patient is eligible for a subcutaneous defibrillator, a device that treats dangerous heart rhythms. Researchers will use artificial intelligence to analyze the standard ECG scans from 10…

This study is testing a new, less invasive way to screen for stomach cancer. Participants swallow a small, magnet-guided video capsule (like a pill camera) that takes pictures inside the stomach, assisted by artificial intelligence. The goal is to see if this pill camera is as go…

This study is testing whether a new, structured care plan can improve the final days for patients in intensive care who are on life support and for whom a decision has been made to stop that support. It will compare the new plan, which includes special training for staff on manag…

This study is checking on patients years after they had a special tube placed into their colon to help with severe, treatment-resistant constipation. Researchers will call 80 patients who had the procedure at a French hospital to ask about their quality of life, symptoms, and any…

This study aims to see if adding the numbing medication lidocaine to standard pain care can help adults with sickle cell disease use fewer opioid painkillers during severe pain crises. It will involve 104 adults admitted to the intensive care unit for these crises. The main goal …

This study aims to understand how stroke or spinal cord injury affects the Achilles tendon and calf muscle during walking. Researchers will measure tendon stiffness, muscle strength, and walking patterns in 60 participants (40 with neurological conditions and 20 healthy volunteer…

This study aims to understand if severe, long-term gum disease (periodontitis) makes arteries stiffer, which is a known risk factor for heart problems. Researchers will compare artery stiffness in 206 adults, half with severe gum disease and half with healthy gums, who are otherw…

This study aims to understand why some children get very sick from bacterial infections while others do not. Researchers will look at the genes, immune systems, and long-term health of over 1,400 children in France who were previously hospitalized with severe infections. The goal…

This study aims to see if testing wastewater from nursing homes can help estimate how many residents are carrying antibiotic-resistant bacteria. Researchers will collect stool samples from 1,600 residents and test the facility's wastewater to build a predictive model. The goal is…

This study aims to learn more about how the body's natural killer (NK) immune cells fight blood cancers like leukemia. Researchers will collect blood and bone marrow samples from 55 adult patients with acute leukemia or myelodysplastic syndrome at diagnosis and over one year. The…

This study aims to better understand early knee osteoarthritis by collecting small tissue samples from the joint lining. Researchers will analyze these samples from 30 patients to look for patterns linked to pain and disease progression. The goal is to gather knowledge that could…

This study aims to understand what happens to people's weight over time after they stop or change their treatment with the obesity medication semaglutide (Wegovy). Researchers will follow 3,000 patients in France with severe obesity to see how their weight changes and identify wh…

This study is testing a new type of ultrasound scan to see if it can help doctors understand muscle health in older adults. Researchers want to see if measuring fat inside muscles can predict how well a person recovers their strength and mobility after a hospital stay. The study …

This French study aims to understand why some B-cell lymphomas become resistant to chemotherapy and newer treatments. Researchers will collect blood and tissue samples from 80 patients before and after their treatment courses. By studying these samples, they hope to identify biol…

This study is testing a new type of ultrasound scan to see if it can accurately measure how muscular dystrophy damages muscles over time. Researchers will compare scans from 60 boys and men with Duchenne or Becker muscular dystrophy to scans from healthy volunteers, tracking chan…

This study aims to use artificial intelligence (AI) to better predict which patients with inherited heart diseases are at high risk for dangerous heart rhythms or heart failure. Researchers will analyze various health data—like heart tests, genetics, and blood markers—from up to …