Nantes University Hospital

This study will follow 100 adults with non-infectious posterior uveitis, a chronic inflammatory eye disease, who have received a fluocinolone acetonide implant. Researchers will analyze medical records over three years to see how well the implant reduces the frequency and severit…

This trial compares two approaches for people with Crohn's disease who have a narrowed section of the small bowel causing symptoms. One group receives a combination of two drugs (azathioprine and infliximab), while the other group undergoes surgery to remove the narrowed segment.…

This study tests a new technique called PWI-Box, which uses a device named GeminiS to isolate the pulmonary veins and treat atrial fibrillation (AF) during open-heart surgery. About 200 adults with AF who are already scheduled for heart surgery via sternotomy will take part. The …

This study tests a computer program called PRIMUS that helps neurologists choose treatments for people with relapsing-remitting multiple sclerosis (MS). The tool uses data from past patients to predict how the disease might progress under different therapies. Doctors in some clin…

This study will test a new line of massive prosthetic implants (the Pantheon range) in 375 people who have lost large amounts of bone due to cancer, complex fractures, or failed previous surgeries. The implants are designed to restore function quickly and stay stable long-term. R…

This early-stage trial tests the safety of a drug called Anakinra in 15 people who have just received a pancreas transplant. The goal is to see if blocking a certain immune signal can prevent dangerous blood clots and improve transplant success. Researchers will closely monitor f…

This early-phase trial tests adding tocilizumab, a drug used for arthritis, to standard chemotherapy (azacitidine and venetoclax) for adults with acute myeloid leukemia (AML) who cannot have intensive treatment. The main goal is to find a safe dose and check for side effects. Onl…

This pilot study will test whether psilocybin (the active ingredient in magic mushrooms) combined with psychotherapy can help people with gambling disorder. Thirty adults will receive either a high dose (25-40 mg) or a very low dose (1 mg) of psilocybin during therapy sessions. T…

This trial tests whether cooling patients to 33°C (therapeutic hypothermia) improves survival and brain function compared to keeping them at normal body temperature after an in-hospital cardiac arrest. About 788 comatose adults who had a cardiac arrest in the hospital will be ran…

This study tests a special radioactive tracer called [68Ga]Ga-FAPI-46 for PET scans in 40 people with transthyretin cardiac amyloidosis (ATTR-CM), a condition where abnormal proteins build up in the heart. The goal is to see if this scan can measure scar-like activity in the hear…

This study tests a new, less invasive way to screen for stomach cancer using a magnetic-guided video capsule that patients swallow. The capsule is steered by a robot and uses AI to check the stomach for suspicious spots. Researchers will compare its accuracy to standard endoscopy…

This study investigates whether a high-concentration capsaicin patch can reduce chronic neuropathic pain in the pelvic and perineal region. Researchers will measure changes in pain sensitivity before and after treatment in 30 adults with long-lasting pelvic nerve pain. The goal i…

This study compares doing brain stimulation (tDCS) at home versus in the hospital for people with moderate to severe depression. The goal is to see if home treatment works just as well, making care more accessible. Sixty-six adults will receive 20 sessions over two weeks, with nu…

This study tests a 10-week cognitive remediation program for people with alcohol use disorder who are recently sober. The program includes group and individual brain exercises to improve thinking skills and self-confidence. Researchers will measure changes in general self-efficac…

This study tests whether a structured palliative care protocol, combined with staff training, can improve end-of-life care for ICU patients on ventilators. Researchers will compare the protocol to usual care across multiple centers. The goal is to ensure patients are comfortable …

This study tests whether adding lidocaine, a numbing medicine, to standard pain treatment can lower the amount of strong opioids needed during severe sickle cell pain crises. About 104 adults with sickle cell disease who are in the intensive care unit for a pain crisis will take …

This French study will collect medical data and biological samples from 800 people with autoimmune liver diseases. Researchers hope to identify new markers that explain why some patients respond well to treatment while others do not. The goal is to better understand the immune me…

This study will analyze respiratory samples from 1,000 patients in France to understand why some Aspergillus fungi become resistant to common antifungal drugs. Researchers will test samples for resistance and collect information about patients' environments, jobs, and medication …

This study will collect blood and bone marrow samples from 55 adults with acute leukemia or myelodysplastic syndrome. Researchers want to understand how natural killer (NK) cells interact with cancer cells over time. The goal is to identify genetic markers and immune patterns tha…

This study collects blood and bone marrow samples from 80 people with B-cell non-Hodgkin lymphoma to explore why some cancers resist chemotherapy. Researchers will analyze the tumor and its environment, and develop lab models to test new treatments. The goal is to uncover resista…

This study follows 120 adults with ANCA-associated vasculitis, an autoimmune disease, who are receiving rituximab therapy. Researchers will collect blood samples over time to look for immune cell changes that signal a coming relapse. The goal is to find biomarkers that help docto…

This study tests whether adding health messages to lab reports can reduce serious heart and kidney problems in people with both diabetes and chronic kidney disease. Over 125,000 participants will be randomly assigned to receive either routine care or extra health messages in thei…

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis, a condition causing muscle stiffness after stroke or spinal cord injury. Researchers will measure tendon stiffness, length, and volume using ultrasound and motion analysis. The goal…

This study will follow 3,000 French patients with severe or complicated obesity who are taking semaglutide (Wegovy) as part of an early access program. Researchers will track weight changes, treatment patterns, and well-being over time using questionnaires. The goal is to underst…

This study will look at how jaw bone quality changes over time in patients with medication-related osteonecrosis of the jaw (MRONJ), a side effect of drugs like bisphosphonates. Researchers will analyze existing CBCT scans from 25 adults to measure bone density and structure at d…

This study looks at whether analyzing synovial tissue can help doctors better manage pigmented villonodular synovitis (PVNS), a rare joint disease that causes pain and joint damage. Researchers will collect tissue samples from 30 patients through biopsy or surgery to assess quali…

This study looks at whether a standard 12-lead electrocardiogram (ECG) can tell if a patient is eligible for a subcutaneous defibrillator (S-ICD), a device that prevents sudden cardiac arrest. Currently, patients need a special 3-lead screening ECG, but researchers want to see if…

This study follows 80 adults who had a tube placed into their bowel (called a percutaneous endoscopic caecostomy, or PEC) to treat severe chronic constipation that didn't improve with standard treatments. Researchers will check long-term quality of life and how well the tube work…