Scientists hunt for clues to chemo resistance in blood cancer

NCT ID NCT07385612

Not yet recruiting Knowledge-focused Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study collects blood and bone marrow samples from 80 people with B-cell non-Hodgkin lymphoma to explore why some cancers resist chemotherapy. Researchers will analyze the tumor and its environment, and develop lab models to test new treatments. The goal is to uncover resistance mechanisms and identify genes involved, which could lead to better therapies in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could identify why some B-cell lymphomas resist chemotherapy, pointing toward new treatment targets.
What could go wrong: This is an observational study that collects samples, not a treatment trial. It may not directly lead to new therapies, and results may take years to translate into clinical use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell neoplasm B-cell non-Hodgkin lymphoma mantle cell lymphoma neoplasm of mature B-cells

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MATURE B-CELL LYMPHOIDS

Contacts and locations

Locations

CH de Saint-Nazaire

Saint-Nazaire, France
CHD Vendée

La Roche-sur-Yon, France
CHU Nantes

Nantes, France
CHU de Poitiers

Poitiers, France

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