New heart surgery technique aims to stop AFib in its tracks

NCT ID NCT07312149

Not yet recruiting Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new technique called PWI-Box, which uses a device named GeminiS to isolate the pulmonary veins and treat atrial fibrillation (AF) during open-heart surgery. About 200 adults with AF who are already scheduled for heart surgery via sternotomy will take part. The main goal is to see if this approach reduces AF recurrence one year after surgery, as measured by a 24-hour heart monitor.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GeminiS device for pulmonary vein isolation with posterior wall isolation (PWI-Box)
What this could lead to: If successful, this could offer a simpler, more reproducible way to treat atrial fibrillation during open-heart surgery, potentially reducing AF recurrence and stroke risk.
What could go wrong: This is an early-stage study (not yet recruiting) with 200 participants. The technique may not work as well as hoped, and surgery carries standard risks like infection or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION (AF) CARDIAC SURGERY

Contacts and locations

Locations

CHU de Nantes

Nantes, 44093, France

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