Could continuing a common heart drug before surgery save lives?

NCT ID NCT07766109

First seen Aug 14, 2026 ยท Last updated Aug 14, 2026

Summary

This trial asks whether people with heart failure who take SGLT-2 inhibitors (like dapagliflozin or empagliflozin) should continue the medication right up to cardiac surgery, rather than stopping it three days before as currently recommended. The study will compare outcomes like heart damage, low cardiac output, rehospitalization, and death within 30 days after surgery. About 434 adults scheduled for heart surgery with a heart pump will be randomly assigned to either continue or stop their medication. The goal is to see if keeping the drug on board improves recovery and reduces complications.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
SGLT-2 inhibitors (dapagliflozin or empagliflozin) continued until surgery morning versus stopped 3 days before
What this could lead to
If continuing SGLT-2 inhibitors before cardiac surgery proves beneficial, it could reduce heart complications and hospital readmissions after surgery.
What could go wrong
This is a phase 4 trial with 434 patients, so results may not apply to all. There is a known risk of ketoacidosis if the drug is continued, and the trial may not show a clear benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University Hospital of TOULOUSE

    Toulouse, France

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