Could continuing a common heart drug before surgery save lives?
NCT ID NCT07766109
First seen Aug 14, 2026 ยท Last updated Aug 14, 2026
Summary
This trial asks whether people with heart failure who take SGLT-2 inhibitors (like dapagliflozin or empagliflozin) should continue the medication right up to cardiac surgery, rather than stopping it three days before as currently recommended. The study will compare outcomes like heart damage, low cardiac output, rehospitalization, and death within 30 days after surgery. About 434 adults scheduled for heart surgery with a heart pump will be randomly assigned to either continue or stop their medication. The goal is to see if keeping the drug on board improves recovery and reduces complications.
What this could mean
Our plain-language read of the trial. This is informational only โ not medical advice or a prediction.
- Active substance
- SGLT-2 inhibitors (dapagliflozin or empagliflozin) continued until surgery morning versus stopped 3 days before
- What this could lead to
- If continuing SGLT-2 inhibitors before cardiac surgery proves beneficial, it could reduce heart complications and hospital readmissions after surgery.
- What could go wrong
- This is a phase 4 trial with 434 patients, so results may not apply to all. There is a known risk of ketoacidosis if the drug is continued, and the trial may not show a clear benefit.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University Hospital of TOULOUSE
Toulouse, France
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