Systolic heart failure

This study tests a new device that creates a small passage in the heart to relieve pressure, without leaving a permanent implant. It is for 350 people with heart failure and reduced pumping ability. The goal is to see if it reduces deaths, need for a heart pump or transplant, and…

This trial tests whether a gentle electrical stimulation applied to the ear—a technique called low-level transcutaneous vagus nerve stimulation—can help older adults with systolic heart failure. The study will compare daily one-hour sessions of real stimulation versus a sham (ina…

This study tests whether the drug vericiguat can help children with heart failure caused by a weak left heart chamber. About 342 children aged 1 month to 18 years will receive either vericiguat or a placebo for 16 weeks. The main goal is to see if the drug lowers a key heart stre…

This clinical trial is testing an experimental drug called CRD-4730 in people with heart failure with reduced ejection fraction (HFrEF), a condition where the heart's main pumping chamber is weak. The drug works by blocking a protein called CaMKII, which is thought to contribute …

This Phase 3 study tests whether adding vicadrostat to the standard drug empagliflozin helps adults with chronic heart failure and a weak heart pump (ejection fraction below 40%). About 4200 participants will take either vicadrostat or a placebo, plus empagliflozin, once daily fo…

This study tests whether sending doctors a reminder about IV iron guidelines helps heart failure patients with iron deficiency get the recommended treatment. About 3,000 hospitalized adults with heart failure and low iron will be included. Doctors in the intervention group receiv…

This study compares a newer pacing method (Left Bundle Branch Area Pacing) with the standard cardiac resynchronization therapy for people with heart failure. About 850 adults with moderate to severe heart failure will take part. The goal is to see if the newer method reduces deat…

This study tests a device called Aortix, a small pump placed in the main artery, to help remove excess fluid in people hospitalized with acute heart failure who are not responding well to diuretic medications. About 320 participants will be randomly assigned to receive either the…

This study tests a device that stimulates the diaphragm in time with the heartbeat to help people with heart failure. Researchers will see if it improves heart function, exercise ability, and quality of life. About 270 participants will receive the device plus standard care, or s…

This study tests an investigational drug called omecamtiv mecarbil in 1,800 adults with severe heart failure and a very weak heart pump. The goal is to see if it can lower the risk of heart failure worsening, hospitalization, need for a heart pump or transplant, or death. Partici…

This study tests whether lumacaftor, a drug used for cystic fibrosis, can improve blood flow to the brain and thinking abilities in people with stable heart failure and reduced pumping function. About 60 participants will receive either lumacaftor or a placebo for one month. The …

This study tests whether an electronic alert in a patient's medical record can prompt doctors to prescribe guideline-recommended heart failure medications that are not yet being used. The trial includes 5,000 adults with heart failure and a reduced ejection fraction (≤40%) seen a…

This study tests two simple tools to improve medication use in people with heart failure with reduced ejection fraction (HFrEF). One tool is a short animated video and checklist sent to patients before a clinic visit to encourage them to discuss their medications. The other is an…

This phase 3 trial tests whether finerenone, a non-steroidal mineralocorticoid receptor antagonist, can reduce cardiovascular death and heart failure events in patients with heart failure and reduced ejection fraction who cannot tolerate or are not eligible for standard steroidal…

This study tests a special pacemaker setting called SyncAV, used with left bundle branch area pacing, in people with heart failure and a heart block. The goal is to see if this setting can improve the heart's electrical timing and pumping strength. About 50 adults who already nee…

This early-stage trial is testing an experimental drug called HJB647 in 12 adults with stable chronic heart failure and reduced pumping ability. The study aims to check the drug's safety and how the body processes it at two different doses. Participants will receive both the drug…

This phase 3 trial tests whether Qishen Yiqi Dripping Pills, a traditional Chinese herbal medicine, can improve exercise ability and quality of life in people with chronic heart failure caused by coronary heart disease. The study enrolls adults aged 18 to 80 with reduced heart pu…

This study tests a device that uses radiofrequency energy to treat high blood pressure in the lungs (pulmonary hypertension) in people with heart failure. The goal is to see if it can reduce serious heart events like hospitalizations or death. About 750 adults with stable heart f…

This study looks at whether changing from standard heart failure medications to a newer drug (sacubitril-valsartan) can improve the health and daily life of people with heart failure in rural Tanzania. About 298 adults with heart failure will be switched to the new drug and follo…

This study tests whether a small wireless sensor placed in the pulmonary artery can help doctors better manage medications for people with heart failure and a leaky mitral valve. The sensor constantly measures pressure inside the heart, giving doctors real-time data to adjust tre…

This study tests a device called Barostim that is implanted in the body to stimulate blood pressure sensors, which may help the heart work better. It involves 58 adults with heart failure who are already on the best available medications. The goal is to see if the device improves…

This study compares weight loss using semaglutide (a drug) versus a calorie-restricted diet in 100 people with obesity and heart failure with reduced ejection fraction. The goal is to see which approach better improves peak oxygen uptake, a measure of exercise capacity, after 52 …

This study looks at whether the diabetes drug dapagliflozin can improve how well the right side of the heart works after off-pump coronary bypass surgery. Researchers will measure heart function in 72 patients with weak hearts before and after 6 months of taking the drug. The goa…

This study looks at whether adding a low dose of digoxin to usual heart failure treatments helps people feel better and live well after a recent hospital visit for worsening heart failure. About 120 adults with weak heart pumping function will take digoxin or continue their curre…

This study compares two breathing support methods—high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV)—in heart failure patients after their breathing tube is removed. The goal is to see which method better prevents the need for re-insertion of the breathing tube or …

This study tests whether a carefully controlled high-fat diet can improve heart function in people with a specific type of heart failure (non-ischemic dilated cardiomyopathy). Researchers believe that switching the heart's fuel source back to fats may help it pump more effectivel…

This study tests a new pacing method called left bundle branch area pacing for people with heart failure whose heart pumps less blood than normal (ejection fraction 50% or lower). It is for patients who cannot get standard pacing or need a backup option. The goal is to see if thi…

This study tests whether a high-protein DASH diet, resistance exercise, or both can help people with heart failure and reduced ejection fraction maintain or increase muscle mass. About 100 adults over age 30 with stable heart failure will take part. The goal is to see if these li…

This study tests whether telemedicine follow-up helps doctors adjust heart failure medications more effectively than standard in-person visits. Eighty adults with newly diagnosed heart failure with reduced ejection fraction will be randomly assigned to either remote monitoring or…

This study tests a small device implanted in the heart that measures pressure and creates a small opening to help blood flow. It is for people with chronic heart failure whose heart pumps weakly (ejection fraction 40% or less) and who still have symptoms despite standard treatmen…

This study looks at whether a procedure called catheter ablation (using heat or cold to fix faulty heart signals) is better than standard medications for people with both atrial fibrillation and heart failure. About 1,200 adults will be randomly assigned to receive either ablatio…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 754 people with severe coronary artery disease and a weak heart pump. The goal is to see which approach better prevents death, stroke, heart attacks, or repeat procedures over 5 years. Par…

This study tests whether a digital remote-management platform can help doctors better adjust heart failure medications after patients leave the hospital. About 252 adults with heart failure and reduced pumping function will use the platform to report symptoms and vital signs, wit…

This study tests whether taking a daily selenium supplement (200 micrograms) can reduce hospitalizations and heart-related deaths in people with heart failure. Selenium is a nutrient important for heart health, and low levels are common in Northern Europe. The trial will include …

This study looks at whether people whose heart failure has improved can safely cut back on some of their daily medications. Participants will either continue all four standard drugs or gradually reduce to just two under close monitoring. The goal is to see if heart function stays…

This study compares two types of heart pacing—conduction system pacing and standard biventricular resynchronization—in 320 adults with heart failure and wide QRS. The goal is to see which method better reduces the risk of death, heart transplant, or hospitalization for heart fail…

This study tests a new remote monitoring system called SmartSignalHF in 1132 adults with heart failure who have an implanted heart device (ICD or CRT-D). The goal is to see if this system can reduce deaths and hospital stays over 12 months compared to standard care. Participants …

This study looks at whether a special heart device called cardiac contractility modulation (CCM) can help people with heart failure live longer and avoid hospital stays. About 4,200 people with advanced heart failure will either get the device or standard care. The goal is to see…

This study tests whether a one-year program led by heart failure nurses, using online training and a mobile app, can reduce repeat hospital stays and improve quality of life for people with heart failure. About 200 adults who were recently hospitalized for worsening heart failure…

This study tests a potential new medicine called CDR132L in 200 people with heart failure and an enlarged heart. Participants receive either CDR132L or a placebo by IV every 4 weeks for 48 weeks. The goal is to see if the drug can improve heart structure and function.

This study looks at whether a personalized home exercise program can improve heart and kidney function in adults aged 18-75 who have both chronic heart failure and kidney problems (cardiorenal syndrome). Sixty participants will either receive standard medication alone or medicati…

This pilot study tests whether the drug eplerenone is safe and feasible for people with both heart failure (reduced pumping ability) and severe chronic kidney disease. Previous studies excluded such patients due to risks like high potassium. The trial will enroll 40 participants …

This study tests whether heart failure patients who fully recover after treatment for a fast heart rhythm (like atrial fibrillation) can safely stop their heart failure medications. 348 participants will be randomly assigned to either gradually stop their drugs or continue them a…

This study aims to find out which type of specialist pacemaker works best for people with heart failure and a delay in how the heart's lower chambers beat together. Sixty participants will be randomly assigned to one of three pacing methods and followed for six months. Researcher…

This early-stage trial tests a patch made from stem cells that is implanted onto the heart to help it pump better. It is for people with severe heart failure who cannot have a heart transplant. The study will check if the patch is safe and if it improves heart function and sympto…

This study looks at whether the drug vericiguat can help repair the hearts of adults with stable heart failure with reduced ejection fraction (HFrEF). Researchers will compare people taking vericiguat plus standard care to those on standard care alone, measuring changes in heart …

This study tests if using two devices together can help people with advanced heart failure. Participants get a CardioMems sensor to monitor heart pressure and later a BaroStim device to regulate blood pressure. The goal is to improve symptoms, walking ability, and reduce hospital…

This early study tests a device called ContraBand™, which is implanted in the lung arteries to reduce pressure on the heart. The goal is to see if it's safe and can improve exercise ability and symptoms in people with left-sided heart failure. About 55 adults with moderate to sev…

This study tests whether using portable air filters at home can improve the health of people with heart failure. Researchers will measure how far participants can walk in six minutes, along with blood pressure and heart-related blood markers. The study involves 255 adults in Indi…

This study looks at 140 heart failure patients to see if taking a medicine called ARNI before coming to the hospital leads to better short-term health. Researchers will compare those who were already on ARNI with those who were not, tracking heart and kidney events during the hos…

This study is testing a small device called the MiniLung petite kit, which helps oxygenate blood and remove carbon dioxide in newborns and children weighing 2 to 8 kilograms who have severe breathing or heart failure. The device works with a console to temporarily take over the w…

This study tests whether briefly inflating a blood pressure cuff on the arm before a heart procedure can protect the kidneys and heart in people with congestive heart failure. About 240 participants will be randomly assigned to receive either the real cuff inflations or a sham ve…

This phase 4 trial tests whether taking ramipril once daily or split into two smaller doses works better for protecting kidney function in 80 adults with chronic kidney disease and heart failure. Over 30 days, researchers will measure changes in blood markers of kidney function, …

This study looks at 100 people with heart failure who need a special pacemaker. Doctors want to see if a heart ultrasound before the procedure can predict which pacing method—left bundle branch pacing or standard biventricular pacing—works better. The goal is to improve how well …

This study tests whether using telemedicine (video or phone check-ins) can help doctors better adjust heart failure medications after patients leave the hospital. About 140 adults with heart failure and reduced pumping ability will be split into two groups: one gets usual care, t…

This study looks at whether adding protein supplements to the diet can prevent muscle wasting in people with heart failure. About 120 adults with heart failure and reduced pumping ability will be randomly assigned to receive no, low, or high doses of protein drinks. The main goal…

This study tests a program called Transition to Cardiac Rehabilitation (T2CR) for Veterans with heart disease who also have other health problems or frailty. The program starts in the hospital and continues at home, helping patients build skills and motivation to do cardiac rehab…

This study tests whether a cardiometabolic clinic can help obese adults with heart disease lose weight and improve health. Sixty participants will receive care from the clinic and be followed for 12 months. Researchers will measure weight loss, body mass index, and fat distributi…

This study tests two water pills—acetazolamide and metolazone—added to standard diuretics in 320 adults hospitalized with acute decompensated heart failure. The goal is to see which drug clears fluid buildup faster and more safely, reducing hospital stays and complications. Parti…

This study tests whether the drug sacubitril/valsartan (Entresto) can improve heart function in people who have a prosthetic (artificial) heart valve and heart failure with reduced pumping ability. About 220 adults will either get the drug plus standard care, or standard care alo…

This study tests a newer heart pacing method (His or left bundle branch pacing) against the standard method (biventricular pacing) in over 2,000 adults with heart failure and a weak heart pump. The goal is to see which approach better improves quality of life, reduces hospital st…

This study compares two common heart failure medications, carvedilol and metoprolol succinate, in 2,000 adults who have an implantable cardioverter defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol…

This study tests whether a newer pacing method called left bundle branch pacing (LBBP) works better than the standard biventricular pacing for people with chronic heart failure and reduced pumping ability. About 60 adults with heart failure and a specific electrical delay in the …

This study compares two ways of delivering cardiac rehabilitation: in-person sessions and telehealth sessions. Cardiac rehab includes exercise training, health education, and counseling for people with heart conditions like heart attack, heart failure, or after heart surgery. The…

This study uses the Swedish Heart Failure Registry to identify people with heart failure and reduced ejection fraction who may need medication adjustments, iron deficiency screening, device therapy, or physiotherapy. Researchers will compare outcomes for 500 patients who receive …

This study is testing whether a digital stethoscope, combined with artificial intelligence, can detect two serious conditions: high blood pressure in the lungs (pulmonary hypertension) and a weak heart pump (low ejection fraction). About 3,850 adults will have their heart sounds …

This study tests a wearable ring that measures blood pressure, comparing it to the standard 24-hour monitor in 100 people with heart failure and reduced pumping ability. The goal is to see if the ring is accurate and easy to use. If successful, it could make blood pressure tracki…

This study tests an artificial intelligence program that analyzes heart rhythm data from a small, wearable patch to estimate how well the heart pumps blood. Researchers will compare the AI's results to standard ultrasound in 2,000 adults. If accurate, this could offer a simpler, …

This study tests whether artificial intelligence (AI) can analyze routine heart tests (ECGs) to find hidden heart problems like weak heart muscle, valve issues, or high lung pressure. About 590 adults without a prior heart disease diagnosis will have ECGs taken with standard mach…

This study tests whether adding inspiratory muscle training (using a device called PowerBreathe) to standard cardiac rehabilitation can improve how well the heart and muscles work during exercise in people with heart failure. Researchers will measure blood flow and oxygen use in …

This study tests whether combining breathing exercises with cognitive tasks (like memory games) can improve thinking and daily function in adults with heart failure. 54 participants will be randomly assigned to dual-task breathing training, standard breathing training, or a contr…

This study looks at whether a special type of exercise called eccentric training (where muscles lengthen under tension) can help people with heart failure and reduced pumping ability. Researchers will compare eccentric bike and strength training to standard cardio and strength ex…

This study tests whether blocking signals from the splanchnic nerve can reduce congestion and improve exercise ability in people with heart failure. About 54 adults with heart failure and reduced pumping function will receive either a nerve-blocking procedure or a sham procedure.…

This study tests whether a daily capsule of potassium nitrate (KNO3) can improve leg muscle power and overall exercise capacity in people with heart failure. 75 adults with reduced heart function will take either KNO3 or a placebo for 6 weeks. Researchers will measure changes in …

This study looks at whether giving a special ketone drink through a feeding tube is safe and practical for people with severe heart failure. The goal is to see if it can help the heart use energy better. The study involves 12 participants with very weak hearts who are in the hosp…

This study tests a digital support program for 240 adults with heart failure. The program, accessed via a secure online portal, aims to help patients feel more in control of their condition and improve their quality of life. Participants use the program for six months, and resear…

This study looks at whether listening to music during a special exercise test can improve how well the heart and lungs work in people with heart failure. About 40 adults with heart failure will take part. Researchers will measure things like oxygen use and breathing to see if mus…

This study looks at whether shorter or longer sessions of high-intensity interval training (HIIT) work better for people with chronic heart failure. Researchers will measure changes in walking ability, heart function, and quality of life in 45 participants. The goal is to find a …

This study tests a home-based cardiac rehabilitation program delivered through a custom mobile app for people with heart failure. Participants use the app for education, mindfulness, and physical activity guidance, plus periodic video calls with an exercise physiologist. The goal…

This study looks at whether two proteins released by a struggling heart can be detected in the blood during acute heart failure. Researchers will measure these proteins in about 500 adults—some with stable or worsening heart failure and some healthy—to see if higher levels relate…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study compares two ultrasound techniques—2D and 3D speckle-tracking echocardiography—to see which measures heart muscle contraction more accurately in people with heart failure and reduced pumping function. Researchers will enroll 419 patients from seven cardiac rehabilitati…

This study looks at whether training doctors on quickly starting and adjusting heart failure medications (called GDMT) during a hospital stay leads to better treatment after discharge. About 438 adults with heart failure and reduced ejection fraction will be observed across multi…

This study looks at why some people with severe heart failure (called HFrEF) see their heart function improve after standard medical therapy, while others do not. Researchers will collect blood samples and imaging data from 1,740 patients in China and follow them for 12 months. T…

This study observes 1350 Korean adults with chronic heart failure who are prescribed Verquvo by their doctors. Researchers will track side effects and heart-related events over up to 12 months to see how safe and effective the drug is in everyday use. No experimental treatments a…

This study looks at whether a person's genetic makeup can predict how well they respond to the heart failure drug metoprolol. Researchers will give the drug to 100 people with heart failure and track their heart function and drug levels. The goal is to see if a genetic score can …

This study tests whether pacing the heart to mimic the speed of a workout can improve heart function in people with heart failure. Fifty-two adults with a weak heart and an implanted defibrillator will receive either active pacing or a sham (fake) pacing for 6 weeks. Researchers …

This study tests whether a new referral program helps more Veterans with heart conditions get into cardiac rehabilitation. Researchers will compare referral and attendance rates before and after the program starts at three VA hospitals, involving 816 participants over 12 months. …

Researchers at the University of Calgary are testing a new, non-invasive way to assess heart function using a handgrip exercise. The study involves 100 adults, half with heart failure and half without. Participants squeeze a device with maximum force for two minutes while sensors…

This study aims to create a digital decision-making aid for older adults with heart failure who are considering getting an implantable cardioverter-defibrillator (ICD). The tool will help patients weigh the benefits of preventing sudden cardiac death against the downsides of the …

This study looks at how a common diabetes drug (SGLT2 inhibitor) changes the way the heart and muscles use energy from ketones. Researchers want to see if these changes can improve exercise ability and daily function in 30 adults with type 2 diabetes and heart failure. Participan…

This study looks at tiny structures inside heart cells called mitochondria in people with heart failure and clogged arteries. Researchers will take small heart tissue samples during bypass surgery and compare them with blood tests. They want to see if damaged mitochondria are lin…

This study is testing new heart MRI techniques to see how the heart adapts to stress, like exercise or fluid changes. Researchers will study 135 healthy volunteers and people with heart conditions. The goal is to improve understanding of heart function and develop better diagnost…

This study is testing whether a special wearable device, combined with artificial intelligence, can help people with chronic heart failure avoid hospital visits. About 205 adults will wear the device for six months while their health data is monitored remotely. The goal is to see…

This study creates a live registry of up to 40,000 heart failure patients across the Yale New Haven Health System. Researchers will track hospitalizations and use of recommended therapies like beta blockers and ACE inhibitors. The goal is to monitor and improve heart failure care…

This study looks at whether pharmacist-led medication checkups and easy-to-understand education can help people with heart failure get the right medicines. It involves 40 patients in Denver who have limited access to care. The goal is to see if this approach is practical and impr…

This study tests whether heart failure patients can safely drink as much fluid as they want instead of restricting it. Researchers will compare lung congestion, blood markers, quality of life, and hospital readmissions in 326 participants over time. The goal is to see if liberal …

This study from Stanford University is looking at what happens inside the body when people with heart failure exercise. Researchers will measure thousands of proteins in the blood before and after a single workout, and again after a 12-week cardiac rehab program. By comparing the…

This study looks at how extreme head-down positioning (Trendelenburg) and gas inflation during robotic surgery affect the heart's ability to pump blood. Researchers will monitor 80 patients—some with normal heart function and some with heart failure—using a special probe and brai…

This study looks at how SGLT2 inhibitors, a type of diabetes medicine, change energy levels in the heart and muscles. Researchers will measure key energy molecules in 71 adults with type 2 diabetes and heart failure. The goal is to understand how these drugs work, not to test a n…

This early-phase study is testing whether a drink containing ketones can improve how the heart works in people who have both type 2 diabetes and heart failure with reduced pumping ability. Ten adults will take the drink for seven days while researchers measure heart efficiency wi…

This study aims to understand why the right side of the heart fails in people with heart failure and high blood pressure in the lungs. Researchers will look at heart tissue samples from 50 adults to find the best ways to diagnose and treat this condition. Participants must be bet…

This study follows 100 adults who needed ECMO support for severe heart or lung failure. Researchers will track muscle size, strength, and quality of life over time to understand why some patients develop lasting weakness. No new treatments are being tested; the goal is to gather …

This observational study looks at how fitness level relates to bacteria in the mouth and blood flow to muscles. Researchers will collect mouth swabs, saliva, and blood samples, and measure exercise capacity in 70 adults with heart failure, peripheral artery disease, or overweight…

This study will use cardiac MRI scans to measure heart muscle scarring in 125 people with heart failure and a leaky mitral valve who are scheduled for a MitraClip procedure. Researchers want to see if the amount of scarring predicts how well the heart recovers six months later. P…

This study is tracking 4,000 people in the UK who were recently diagnosed with heart failure and have a weak heart pump (ejection fraction below 50%). Researchers will follow them over time to see how their health changes, what treatments they receive, and how often they are hosp…

This study looks at why some people with heart failure get better with exercise rehab while others don't. Researchers will measure oxygen use during exercise and check tiny molecules in the blood called microRNAs. They hope to find patterns that could one day help design personal…

This study is observing 3000 adults with various types of heart failure to learn how the disease develops and progresses. Researchers will collect medical records, blood samples, and imaging data to identify distinct patient groups. The goal is to match the right treatments to th…

This study tests a hospital-wide treatment guide for people with heart failure and a leaky mitral valve (secondary mitral regurgitation). The goal is to see if the guide helps doctors identify which patients will benefit most from a minimally invasive valve repair procedure calle…

This study is tracking 1,000 adults with psoriasis to see how their skin condition relates to heart disease. Researchers will use blood tests and heart imaging to find early signs of heart problems. The goal is to better understand why people with psoriasis have higher rates of h…