Major trial tests if zapping heart tissue beats pills for common rhythm disorder

NCT ID NCT06505798

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a procedure called catheter ablation (using heat or cold to fix faulty heart signals) is better than standard medications for people with both atrial fibrillation and heart failure. About 1,200 adults will be randomly assigned to receive either ablation plus medication or medication alone. The goal is to see if ablation reduces unplanned hospital visits and deaths over time.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Barts Health NHS Trust

    RECRUITING

    London, United Kingdom

  • Blackpool Victoria Hospital

    RECRUITING

    Blackpool, United Kingdom

  • Freeman Hospital, Royal Victoria Infirmary

    RECRUITING

    Newcastle, United Kingdom

  • Glenfield Hospital

    RECRUITING

    Leicester, United Kingdom

  • Golden Jubilee National Hospital

    RECRUITING

    Glasgow, G81 4DY, United Kingdom

  • Halifax Infirmary

    RECRUITING

    Halifax, Canada

  • Hull University Teaching Hospitals NHS Trust

    RECRUITING

    Hull, United Kingdom

  • Imperial College Healthcare NHS Trust

    RECRUITING

    London, United Kingdom

  • James Cook University Hosptial

    RECRUITING

    Middlesbrough, United Kingdom

  • Leeds Teaching Hospitals NHS Trust

    RECRUITING

    Leeds, United Kingdom

  • Liverpool Heart and Chest Hospital NHS Foundation Trust

    RECRUITING

    Liverpool, United Kingdom

  • Mid and South Essex NHS Foundation Trust

    RECRUITING

    Basildon, United Kingdom

  • Nottingham University Hospital NHS Trust

    RECRUITING

    Nottingham, United Kingdom

  • Queen Alexandra Hospital

    RECRUITING

    Portsmouth, United Kingdom

  • Queen Elizabeth Hospital

    RECRUITING

    Birmingham, United Kingdom

  • Royal Brompton and Harefields Hospitals

    RECRUITING

    London, UB9 6JH, United Kingdom

  • Royal Papworth Hospital NHS Foundation Trust

    RECRUITING

    Cambridge, CB2 0AY, United Kingdom

  • Southampton General

    RECRUITING

    Southampton, United Kingdom

  • St George's University Hospitals NHS Foundation Trust

    RECRUITING

    London, United Kingdom

  • St Thomas' hospital

    RECRUITING

    London, United Kingdom

  • Swansea Bay University Health Board

    RECRUITING

    Swansea, United Kingdom

  • University Hospitals Coventry and Warwickshire NHS Trust

    RECRUITING

    Coventry, United Kingdom

  • University Hospitals Dorset NHS Foundation Trust

    RECRUITING

    Bournemouth, United Kingdom

  • University Hospitals Plymouth NHS Trust

    RECRUITING

    Plymouth, United Kingdom

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