Major trial tests if zapping heart tissue beats pills for common rhythm disorder
NCT ID NCT06505798
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether a procedure called catheter ablation (using heat or cold to fix faulty heart signals) is better than standard medications for people with both atrial fibrillation and heart failure. About 1,200 adults will be randomly assigned to receive either ablation plus medication or medication alone. The goal is to see if ablation reduces unplanned hospital visits and deaths over time.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Barts Health NHS Trust
RECRUITINGLondon, United Kingdom
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Blackpool Victoria Hospital
RECRUITINGBlackpool, United Kingdom
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Freeman Hospital, Royal Victoria Infirmary
RECRUITINGNewcastle, United Kingdom
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Glenfield Hospital
RECRUITINGLeicester, United Kingdom
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Golden Jubilee National Hospital
RECRUITINGGlasgow, G81 4DY, United Kingdom
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Halifax Infirmary
RECRUITINGHalifax, Canada
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Hull University Teaching Hospitals NHS Trust
RECRUITINGHull, United Kingdom
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Imperial College Healthcare NHS Trust
RECRUITINGLondon, United Kingdom
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James Cook University Hosptial
RECRUITINGMiddlesbrough, United Kingdom
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Leeds Teaching Hospitals NHS Trust
RECRUITINGLeeds, United Kingdom
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Liverpool Heart and Chest Hospital NHS Foundation Trust
RECRUITINGLiverpool, United Kingdom
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Mid and South Essex NHS Foundation Trust
RECRUITINGBasildon, United Kingdom
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Nottingham University Hospital NHS Trust
RECRUITINGNottingham, United Kingdom
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Queen Alexandra Hospital
RECRUITINGPortsmouth, United Kingdom
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Queen Elizabeth Hospital
RECRUITINGBirmingham, United Kingdom
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Royal Brompton and Harefields Hospitals
RECRUITINGLondon, UB9 6JH, United Kingdom
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Royal Papworth Hospital NHS Foundation Trust
RECRUITINGCambridge, CB2 0AY, United Kingdom
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Southampton General
RECRUITINGSouthampton, United Kingdom
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St George's University Hospitals NHS Foundation Trust
RECRUITINGLondon, United Kingdom
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St Thomas' hospital
RECRUITINGLondon, United Kingdom
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Swansea Bay University Health Board
RECRUITINGSwansea, United Kingdom
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University Hospitals Coventry and Warwickshire NHS Trust
RECRUITINGCoventry, United Kingdom
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University Hospitals Dorset NHS Foundation Trust
RECRUITINGBournemouth, United Kingdom
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University Hospitals Plymouth NHS Trust
RECRUITINGPlymouth, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could continuing a common heart drug before surgery save lives?
- Could a smartphone alert replace daily blood thinners for AF?
- Blood fat clues could flag hidden heart rhythm risk
- Could a natural chemical be the key to safer heart failure treatment?
- Can a new heart ablation technique work without x-rays?
- Which blood thinner is safer for heart patients? a Head-to-Head test