University College, London

This large UK trial is testing if adding one of two new treatments to standard hormone therapy helps men live longer with prostate cancer that has spread. One treatment uses highly targeted radiation (SABR) on a few cancer spots, and the other uses a radioactive drug (Lu-PSMA) th…

This large study aims to find out if a less extensive surgery (removing only half the thyroid) is just as good as removing the whole gland for patients with low-risk thyroid cancer. It will compare cancer recurrence rates, side effects like voice changes, and quality of life betw…

This early-stage study is testing whether a new drug called NIO752 can reduce the brain's production of tau protein, which forms toxic tangles in Alzheimer's disease. Researchers will give the drug via spinal injection to 10 participants with mild to moderate Alzheimer's and meas…

This UK trial is testing whether proton beam radiation therapy can help control malignant pleural mesothelioma, a serious cancer often linked to asbestos exposure. Researchers will compare proton therapy against standard watchful waiting in 148 patients whose cancer is confined t…

This large international trial aims to find faster, safer treatments for tuberculosis (TB). It will test 11 new drug combinations, including two promising new drugs, on up to 2,500 adults with lung TB. The goal is to shorten the standard 6-month treatment to as little as 2 months…

This early-stage trial is testing a new personalized cell therapy for children and adults with T-cell leukemia or lymphoma that has come back or not responded to standard treatments. Doctors will collect a patient's own immune cells, modify them in a lab to better target the canc…

This large international trial is comparing two chemotherapy combinations (ABVD vs A2VD) for people with newly diagnosed, early-stage Hodgkin lymphoma. The study uses PET scans after two treatment cycles to personalize further therapy—some patients receive less treatment, some ge…

This study is comparing two methods for attaching a robotic-assisted knee replacement implant: using surgical bone cement versus a cementless design that allows bone to grow into the implant. It aims to find out which method leads to a more natural-feeling, longer-lasting knee fo…

This large international study aims to find out if a heart procedure called catheter ablation, combined with standard medications, works better than medications alone for people who have both atrial fibrillation (an irregular heartbeat) and heart failure. It will enroll 1,200 par…

This large UK trial is testing whether two existing drugs, telmisartan and terazosin, can slow down the progression of Parkinson's disease. It will involve 1,200 people with Parkinson's who are already on standard medication. The trial uses an efficient design to test multiple tr…

This study is testing whether a non-invasive spinal stimulation device can help people with recent spinal cord injuries regain arm and hand function during their hospital rehabilitation. Eighteen participants will receive either real or placebo stimulation along with their standa…

This early-stage trial is testing the safety of a new type of personalized cell therapy for people with advanced multiple myeloma that has stopped responding to standard treatments. Doctors will collect and genetically modify a patient's own immune cells (T cells) to help them fi…

This study is testing a smartphone app designed to screen newborn babies for jaundice, a common condition that can be dangerous if untreated. The app takes a photo of the baby's eye to estimate bilirubin levels, potentially avoiding unnecessary blood tests. Researchers will enrol…

This study aims to understand how a chronic lung infection called NTM-PD affects people's health compared to a similar condition, bronchiectasis, without the infection. Researchers will compare 40 people with each condition using questionnaires and simple physical tests to see if…

This study aims to discover exactly how physical activity helps reduce depression symptoms. Researchers will compare an 8-week aerobic exercise program to a stretching program in 250 adults with moderate depression. They will measure changes in brain activity, body chemistry, and…

This study is testing whether a 21-day self-guided phone app can help prepare people for a psychedelic experience. Forty healthy volunteers will use either a meditation or a music-listening version of the app, then have a supervised psilocybin session. The main goal is to see if …

This study aims to collect spinal fluid and blood samples from 2,500 people at different stages of Huntington's disease. The goal is to find biological markers that can help researchers understand the disease better and develop new treatments. Participants will have annual visits…