University College, London

This phase 2 trial tested whether the immunotherapy drug pembrolizumab (Keytruda) could help keep cancer from growing in people with platinum-resistant ovarian, fallopian tube, or peritoneal cancer. After initial chemotherapy with paclitaxel, 20 participants received pembrolizuma…

This study compared two types of surgery to remove the bladder in people with bladder cancer: one done with a robot and one done as open surgery. About 339 patients took part across multiple hospitals. The main goal was to see which approach let patients spend more days at home a…

This study tested whether the drug rivaroxaban works as well as warfarin to prevent further brain damage in people who have had a stroke due to antiphospholipid syndrome (APS), a condition that causes abnormal blood clotting. About 40 participants took either rivaroxaban or warfa…

This early-stage trial tested the safety of adding olaparib to standard chemotherapy and radiation for people with advanced head and neck cancer. Sixteen patients took part to find the best dose and see how well they tolerated the combination. The goal was to control the disease,…

This study tested whether exenatide, a drug already used for type 2 diabetes, can slow the progression of Parkinson's disease. About 194 people with early-stage Parkinson's received either exenatide or a placebo once a week for two years. The goal was to see if the drug could pro…

This early study tested a new treatment for perianal fistulas (abnormal tunnels near the anus) using tiny absorbable beads called TIPS microspheres. The beads were placed into the fistula during a standard surgical procedure to see if they are safe and help the fistula heal natur…

This study tested two different drug combinations for people with a type of blood cancer called diffuse large B-cell lymphoma (DLBCL) who cannot take the usual strong chemotherapy. The trial compared a newer drug (inotuzumab ozogamicin) plus standard therapy against another commo…

This study tested whether giving drugs based on the genetic makeup of a person's lung cancer could help control the disease. About 50 adults with advanced non-small cell lung cancer received either immunotherapy (atezolizumab) alone or with chemotherapy, or targeted drugs like ve…

This study looked at whether adding cetuximab to avelumab works better than avelumab alone for people with advanced head and neck cancer that has come back or spread. The cancer in these patients is not curable, and average survival is less than a year. The trial first checked th…

This study looked at whether the Appendistat Score (APS) can accurately identify patients with complicated appendicitis who need urgent surgery. Researchers reviewed records of 592 patients who had their appendix removed. They compared the APS score to the final lab results to se…

This early-stage trial tested a new drug called rfhSP-D in 18 premature babies born before 30 weeks. The goal was to find the safest dose that might prevent chronic lung disease, a common complication in preemies. The drug was given along with standard care to babies on breathing…

This study tested an app called iTalkBetter for people who have trouble finding words after a stroke. 31 participants used the app to practice naming specific items. The goal was to see if the app could improve word retrieval for those practiced items. This small trial helps unde…

This study tested whether a 6-session online group program called Compassionate Mind Training (CMT) can improve wellbeing in women aged 40-60 going through menopause. The therapy aims to reduce self-criticism and shame by building self-compassion. Researchers enrolled 38 women to…

This study tested three types of group psychological therapy for people with Parkinson's: one for adjusting to diagnosis, one for anxiety and depression, and one for memory and thinking problems. 138 participants took part, and the therapy was designed to be delivered by non-ment…

This study tested a web-based app called Gotcha! designed to help people with mild-to-moderate dementia remember names of people they know. 48 participants practiced daily for 6 weeks using a tablet at home. The goal was to see if the therapy improves name recall and whether it c…

This study tested a cognitive intervention to help manage 'brain fog'—memory and concentration problems—during menopause. It involved 33 women aged 40-60 who reported cognitive difficulties. The goal was to see if the program was feasible and acceptable, offering a non-hormonal o…

This study tested whether two common drugs (pentoxifylline and vitamin E) can help reduce fibrosis—hardening of tissues—that often occurs after radiation for head and neck cancer. Fifty adults who had radiation at least a year ago and were cancer-free took either the drug combo p…

This study tested whether 90 hours of intensive arm therapy over 3 weeks can improve arm function in people who had a stroke at least 6 months earlier. 105 participants were split into two therapy groups (a standard program or a video-game based program) or a wait-list group that…

This study tested whether a guided meditation called yoga nidra is practical and helpful for people with PTSD and insomnia. Sixty adults who had experienced a stressful or traumatic event and had trouble sleeping took part. They listened to online recordings daily for 8 weeks, an…