University College, London

This early-phase trial tests a new type of immunotherapy for people who develop a rare blood cancer called post-transplant lymphoproliferative disease (PTLD) after a solid organ transplant. The treatment uses the patient's own immune cells (T-cells) that are engineered to resist …

This study looks at whether using a high-efficiency air filter in the bedroom overnight can reduce inflammation and heart-related risks in adult cancer survivors living in highly polluted areas. Ten participants will each try both filtered and unfiltered air for two-week periods,…

This study tested whether the drug rivaroxaban works as well as warfarin to prevent further brain damage in people who have had a stroke due to antiphospholipid syndrome (APS), a condition that causes abnormal blood clotting. About 40 participants took either rivaroxaban or warfa…

This early-stage trial tested the safety of adding olaparib to standard chemotherapy and radiation for people with advanced head and neck cancer. Sixteen patients took part to find the best dose and see how well they tolerated the combination. The goal was to control the disease,…

This study looked at whether adding cetuximab to avelumab works better than avelumab alone for people with advanced head and neck cancer that has come back or spread. The cancer in these patients is not curable, and average survival is less than a year. The trial first checked th…

This phase 2 trial tested whether the immunotherapy drug pembrolizumab (Keytruda) could help keep cancer from growing in people with platinum-resistant ovarian, fallopian tube, or peritoneal cancer. After initial chemotherapy with paclitaxel, 20 participants received pembrolizuma…

This study compared two types of surgery to remove the bladder in people with bladder cancer: one done with a robot and one done as open surgery. About 339 patients took part across multiple hospitals. The main goal was to see which approach let patients spend more days at home a…

This study tested whether exenatide, a drug already used for type 2 diabetes, can slow the progression of Parkinson's disease. About 194 people with early-stage Parkinson's received either exenatide or a placebo once a week for two years. The goal was to see if the drug could pro…

This study tested two different drug combinations for people with a type of blood cancer called diffuse large B-cell lymphoma (DLBCL) who cannot take the usual strong chemotherapy. The trial compared a newer drug (inotuzumab ozogamicin) plus standard therapy against another commo…

This first-in-human study tested whether TIPS microspheres—tiny absorbable beads—can safely help heal perianal fistulas (abnormal tunnels near the anus). Thirteen adults with simple fistulas received the beads during a standard procedure. The main goal was to check safety, with e…

This study looked at whether the Appendistat Score (APS) can accurately identify patients with complicated appendicitis who need urgent surgery. Researchers reviewed records of 592 patients who had their appendix removed. They compared the APS score to the final lab results to se…

This early-stage trial tested a new drug called rfhSP-D in 18 premature babies born before 30 weeks. The goal was to find the safest dose that might prevent chronic lung disease, a common complication in preemies. The drug was given along with standard care to babies on breathing…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This trial tests a school-based counselling program called Knowledge Insight Tools (KIT), which is based on cognitive behavioural therapy (CBT). It is designed for secondary school students aged 11-18 who are struggling with anxiety and low mood. Participants first go through a w…

This study tested whether a 6-session online group program called Compassionate Mind Training (CMT) can improve wellbeing in women aged 40-60 going through menopause. The therapy aims to reduce self-criticism and shame by building self-compassion. Researchers enrolled 38 women to…

This study tested whether a guided meditation called yoga nidra is practical and helpful for people with PTSD and insomnia. Sixty adults who had experienced a stressful or traumatic event and had trouble sleeping took part. They listened to online recordings daily for 8 weeks, an…

This study tested three types of group psychological therapy for people with Parkinson's: one for adjusting to diagnosis, one for anxiety and depression, and one for memory and thinking problems. 138 participants took part, and the therapy was designed to be delivered by non-ment…

This study tested an app called iTalkBetter for people who have trouble finding words after a stroke. 31 participants used the app to practice naming specific items. The goal was to see if the app could improve word retrieval for those practiced items. This small trial helps unde…

This study tested whether two common drugs (pentoxifylline and vitamin E) can help reduce fibrosis—hardening of tissues—that often occurs after radiation for head and neck cancer. Fifty adults who had radiation at least a year ago and were cancer-free took either the drug combo p…

This study tested a cognitive intervention to help manage 'brain fog'—memory and concentration problems—during menopause. It involved 33 women aged 40-60 who reported cognitive difficulties. The goal was to see if the program was feasible and acceptable, offering a non-hormonal o…

This study tested a web-based app called Gotcha! designed to help people with mild-to-moderate dementia remember names of people they know. 48 participants practiced daily for 6 weeks using a tablet at home. The goal was to see if the therapy improves name recall and whether it c…

This study tested whether intensive upper limb rehabilitation helps people who had a stroke at least 6 months ago. 105 participants were randomly assigned to one of two intensive therapy programs or usual care. The goal was to see if high-dose training improves arm movement and f…

This phase 2 trial studied 50 people with non-small cell lung cancer to see if differences within a tumor (called heterogeneity) affect how well treatments work. Patients received one of four drugs based on their tumor's genetic changes: atezolizumab (immunotherapy), vemurafenib,…