University College, London

This study looks at whether low-risk thyroid cancer patients need radioactive iodine treatment after having their thyroid removed. About 504 participants are randomly assigned to receive either a standard dose of radio-iodine or no radio-iodine at all. The goal is to see if skipp…

This phase II trial tests whether adding stereotactic ablative radiotherapy (SABR) to standard anti-cancer therapy improves survival for people with non-small cell lung cancer that has spread to only a few spots (oligometastatic). About 140 participants are randomly assigned to r…

This early-stage trial tests a personalized gene therapy for adults with certain blood cancers that have come back or not responded to standard treatments. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells carrying a protein called CD19.…

This phase 2 trial is testing a combination of two drugs, acalabrutinib and rituximab, in elderly or frail patients who have not yet been treated for mantle cell lymphoma. The goal is to see how well the drugs shrink or control the cancer. The study involves 48 participants aged …

This early-stage trial tests a new treatment called GD2 CAR T cells in 12 children and teens (ages 1-16) with neuroblastoma that has come back or not responded to standard therapy. The treatment involves taking a patient's own immune cells, modifying them to better recognize and …

This study looks at whether giving children with acute lymphoblastic leukemia a daily antibiotic called ciprofloxacin can reduce bacterial infections during the first month of chemotherapy. About 313 children in the UK are taking part. The goal is to see if this approach works be…

This study tests whether advanced MRI scans can tell the difference between aggressive and harmless kidney tumors. Currently, scans can find tumors but not their type, often leading to invasive biopsies or unnecessary surgery. Researchers will give 30 patients an extra MRI before…

This trial tests a new surgical method called NeuroSAFE, which uses real-time tissue analysis during robotic prostate removal to help surgeons avoid damaging nerves. The study includes 407 men with prostate cancer who are potent and continent before surgery. The goal is to see if…

This study tests whether a school-based program called social prescribing can help young people who feel lonely. Instead of medicine, a link worker helps them find activities and support in their community. About 215 students in England will either get this program or just a list…

This study looks at whether people with memory problems will wear and use digital devices like smartwatches, sleep headbands, and smartphone apps to collect health data. Researchers will combine this data with clinical information to build machine learning models that might one d…

This study tests whether Electrical Impedance Tomography (EIT) can produce accurate images of brain activity in people with epilepsy. EIT uses harmless electrical signals through electrodes on the scalp or brain to create images, and is compared to standard methods like MRI and E…

This study looks at how stressed surgeons get during hip and knee replacement surgeries, comparing traditional methods with robot-assisted ones. Six experienced orthopedic surgeons will wear a brain-monitoring headband and heart rate monitors while they operate. The goal is to un…

This study looks at the genetic makeup of lung cancers found through low-dose CT screening. Researchers want to understand why some cancers grow quickly and others grow slowly. About 526 people who had surgery for screen-detected lung cancer will provide tissue samples for DNA an…

This study follows 814 people with early-stage non-small cell lung cancer to understand how the cancer evolves and spreads. Researchers collect tumor samples and medical data to see how genetic changes relate to treatment outcomes. The goal is to find ways to reduce the chance of…

This study looks at whether a blood test that detects cancer DNA can help doctors choose the right treatment for men with advanced prostate cancer. About 192 participants will give extra blood samples during their standard care. The goal is not to test a new drug, but to learn ho…