Can a daily antibiotic keep kids with leukemia safer from infection?

NCT ID NCT04678869

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether giving children with acute lymphoblastic leukemia a daily antibiotic called ciprofloxacin can reduce bacterial infections during the first month of chemotherapy. About 313 children in the UK are taking part. The goal is to see if this approach works better than standard care and to check for antibiotic resistance.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Addenbrookes Hospital

    Cambridge, United Kingdom

  • Alder Hey Children's Hospital

    Liverpool, United Kingdom

  • Bristol Royal Hospital for Children

    Bristol, United Kingdom

  • Great Ormond Street Hospital

    London, United Kingdom

  • John Radcliffe Hospital

    Oxford, United Kingdom

  • Leeds General Infirmary

    Leeds, United Kingdom

  • Leicester Royal Infirmary

    Leicester, United Kingdom

  • Nottingham Children's Hospital

    Nottingham, United Kingdom

  • Royal Aberdeen Children's Hospital

    Aberdeen, United Kingdom

  • Royal Manchester Children's Hospital

    Manchester, United Kingdom

  • Royal Victoria Infirmary

    Newcastle, United Kingdom

  • Sheffield Children's Hospital

    Sheffield, United Kingdom

  • Southampton General Hospital

    Southampton, United Kingdom

  • Univeristy College Hospital London

    London, United Kingdom

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Other studies related to the condition(s) this trial covers.