Scientists hunt for clues to dangerous drug allergies in young leukemia patients

NCT ID NCT07499336

First seen Mar 30, 2026 · Last updated May 12, 2026 · Updated 8 times

Summary

This study aims to find biological markers that can predict which children and young adults with acute lymphoblastic leukemia (ALL) will have severe allergic reactions to the chemotherapy drug PEG-asparaginase. Researchers will collect blood and bone marrow samples from 45 patients (20 with allergies and 20 without) and analyze immune cells to understand why some develop these reactions. The goal is to develop a simple blood test that can identify at-risk patients without needing invasive bone marrow sampling.

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