University College, London

This phase II trial tests whether a 12-week course of higher-dose antibiotics combined with a urinary antiseptic (methenamine hippurate) can better control chronic UTI than standard low-dose antibiotics or antiseptic alone. About 192 adults with daily UTI symptoms for at least 3 …

This early-stage trial is testing a new type of immunotherapy for children and young adults with a high-risk or relapsed form of acute lymphoblastic leukemia. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack leukemia cells tha…

This phase I trial is testing whether giving the immunotherapy drug ipilimumab before standard treatment (surgery and chemoradiation) is safe and helpful for people with newly diagnosed glioblastoma, a type of brain cancer. About 16 participants will receive up to two doses of ip…

This early-stage trial tests whether a new type of CAR T-cell therapy is safe for children and adults with T-cell leukemia or lymphoma that has come back or not responded to standard treatments. The therapy uses a patient's own immune cells, modified in a lab to target a protein …

This study tests whether a home monitoring system called CirrhoCare can help people with decompensated cirrhosis avoid unplanned hospital visits. Participants use an Apple Watch, iPhone app, and Bluetooth devices to track their health at home. The trial will compare this approach…

This trial is testing whether giving the immunotherapy drug pembrolizumab before surgery can improve outcomes for people with high-risk stage 2 or stage 3 colorectal cancer that has a specific genetic feature called mismatch repair deficiency. About 88 participants will receive p…

This early-stage trial tests a drug called NIO752, given via spinal injection, to see if it can reduce production of tau protein in the brain. Tau buildup is linked to Alzheimer's damage. Ten people with mild to moderate Alzheimer's will receive either NIO752 or a placebo, and re…

This study compares two types of robotic-arm assisted knee replacement surgery in 120 people with knee osteoarthritis. One group gets cementless implants, the other gets cemented implants. The main goal is to see which approach helps patients 'forget' they have an artificial knee…

This early-stage trial is testing two types of CAR T cell therapies for people with multiple myeloma that has come back or not responded to standard treatments. The therapies use a patient's own immune cells, modified to target the BCMA protein (alone or together with CD19) on ca…

This large Phase 3 trial tests whether adding targeted radiotherapy (SABR) or a radioactive drug (PSMA-Lutetium) to standard hormone therapy can slow cancer spread and improve survival in people with metastatic prostate cancer. About 3,360 participants across the UK will be rando…

This large Phase 3 trial is testing whether two common drugs, telmisartan and terazosin, can slow the progression of Parkinson's disease. 1,200 participants will receive either a drug or a placebo for up to 36 months. The study uses a flexible design that can add new treatments o…

This study tests new drug combinations to treat pulmonary tuberculosis (TB) faster than the standard 24-week regimen. About 2500 adults with TB will receive one of several experimental combinations, including two new drugs (BTZ-043 and GSK3036656), for 8 to 16 weeks. Researchers …

This study tests whether deep brain stimulation (DBS) can safely reduce seizures in children aged 5-14 with Lennox-Gastaut syndrome, a severe form of epilepsy. The trial uses a special device called Picostim to send electrical pulses to the brain. Researchers will track seizure f…

This phase 3 trial compares two chemotherapy combinations (ABVD and A2VD) for people with newly diagnosed, early-stage Hodgkin lymphoma. About 1,042 participants will receive 3-4 cycles of chemo, with a PET scan after 2 cycles to tailor further treatment. The goal is to see which…

This study looks at whether using a high-efficiency air filter in the bedroom overnight can reduce inflammation and heart-related risks in adult cancer survivors living in highly polluted areas. Ten participants will each try both filtered and unfiltered air for two-week periods,…

This study looks at whether a procedure called catheter ablation (using heat or cold to fix faulty heart signals) is better than standard medications for people with both atrial fibrillation and heart failure. About 1,200 adults will be randomly assigned to receive either ablatio…

This study tests a new injectable radioactive drug, Actinium-225 rhPSMA-10.1, in 60 men with advanced prostate cancer that has spread and stopped responding to standard treatments. The drug aims to attach to and destroy cancer cells with radiation. Participants receive doses ever…

This study tests whether proton beam therapy can help people with a rare cancer called malignant pleural mesothelioma. It involves 148 adults whose cancer is on one side of the chest. The goal is to see if this treatment can slow the cancer and help people live longer with fewer …

This study looks at whether removing only half of the thyroid gland (hemithyroidectomy) works as well as removing the whole gland (total thyroidectomy) for people with low-risk thyroid cancer. About 456 adults with early-stage thyroid cancer will be randomly assigned to one of th…

This study tests a smartphone app called neoSCB that screens newborns for jaundice by taking a photo of the baby's eye. Jaundice affects about 60% of newborns and can cause serious brain damage if untreated, but current visual checks are often inaccurate. The app aims to provide …

This study tests a new method called LaserSAFE that uses a special microscope to scan the prostate right after it is removed during surgery. The goal is to see if it can quickly find cancer cells at the edge of the prostate, which helps surgeons decide whether to save or remove n…

This study looks at whether saving a small extra artery to the penis during robotic prostate cancer surgery can help men recover erections. About 1 in 3 men have this artery, and the study will use MRI scans to find it before surgery. Researchers will follow 20-40 men for a year …

This study tests whether adding a non-invasive spinal cord stimulation technique (TSCS) to standard rehabilitation can improve arm and hand function in people with a recent spinal cord injury. About 18 adults with cervical-level injuries will receive either real or sham stimulati…

This study tests a 21-day digital program that uses either meditation or music to prepare healthy volunteers for a supervised psilocybin session. Forty people will be randomly assigned to one of the two preparation methods. The main goal is to see if the program is practical and …

This study aims to collect cerebrospinal fluid and blood samples from 2,500 people at various stages of Huntington's disease, as well as healthy volunteers. The goal is to find biological markers that can help researchers develop new treatments. Participants must be between 11 an…

This study aims to create a detailed map of the vagus nerve's internal wiring during routine epilepsy surgery. Researchers will use special electrode cuffs to stimulate different parts of the nerve and record which organs respond, while also taking quick electrical images. The go…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study looks at 30 women who have had surgery for stress urinary incontinence before but still have symptoms. Researchers want to see if using a special test (urodynamics or video-urodynamics) before another surgery helps improve results. The goal is to find out which test is…

This study looks at 80 adults to understand how health and quality of life differ between those with NTM lung disease and those with bronchiectasis alone. Participants fill out questionnaires and do simple physical tests in one visit. The goal is to find out what non-drug treatme…

This study aims to understand why physical activity helps with depression. Researchers will compare aerobic exercise to stretching in 250 adults with moderate depression. They will measure changes in brain activity, immune markers, and motivation to uncover the underlying mechani…