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Less surgery may be just as good for Low-Risk thyroid cancer

NCT ID NCT05604963

Recruiting now Disease control Sponsor: University College, London Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two surgical options for people with low-risk differentiated thyroid cancer: removing only part of the thyroid (hemithyroidectomy) or the entire gland (total thyroidectomy). The goal is to see if the less extensive surgery is as effective at preventing cancer recurrence while causing fewer side effects. About 456 participants will be followed for up to 6 years after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

surgical procedure (hemithyroidectomy or total thyroidectomy)

What this could lead to

If successful, this could show that removing only part of the thyroid is a safe and cost-effective option for low-risk thyroid cancer, reducing complications from full removal.

What could go wrong

This is a non-inferiority trial, meaning it aims to prove that less surgery is not worse than more surgery. It may still show higher recurrence rates with partial removal, and results may not apply to higher-risk cancers.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

differentiated thyroid carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFERENTIATED THYROID CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Addenbrooke's Hospital

    RECRUITING

    Cambridge, United Kingdom

    Contact

  • Colchester Hospital

    RECRUITING

    Colchester, United Kingdom

    Contact

  • Derriford Hospital

    RECRUITING

    Plymouth, United Kingdom

    Contact

  • Forth Valley Royal Hospital

    RECRUITING

    Falkirk, United Kingdom

    Contact

  • Glan Clwyd Hospital (Betsi Cadwaladr University Health Board)

    RECRUITING

    Rhyl, United Kingdom

    Contact

  • Guy's Hospital

    RECRUITING

    London, United Kingdom

    Contact

  • Ipswich Hospital

    RECRUITING

    Ipswich, United Kingdom

    Contact

  • Leicester Royal Infirmary

    RECRUITING

    Leicester, United Kingdom

    Contact

  • Leighton Hospital

    RECRUITING

    Crewe, Cheshire, CW1 4QJ, United Kingdom

    Contact

  • Lister Hospital

    RECRUITING

    London, United Kingdom

    Contact

  • Liverpool University Hospitals

    RECRUITING

    Liverpool, United Kingdom

    Contact

  • Luton and Dunstable University Hospital

    RECRUITING

    Luton, United Kingdom

    Contact

  • Medway Maritime Hospital

    RECRUITING

    Gillingham, United Kingdom

    Contact

  • Musgrove Park Hospital

    RECRUITING

    Taunton, United Kingdom

    Contact

  • NHS Greater Glasgow & Clyde

    RECRUITING

    Glasgow, United Kingdom

    Contact

  • NHS Lothian

    RECRUITING

    Edinburgh, United Kingdom

    Contact

  • Ninewells Hospital

    RECRUITING

    Dundee, United Kingdom

    Contact

  • Norfolk and Norwich University Hospital

    RECRUITING

    Norwich, United Kingdom

    Contact

  • Northampton General Hospital

    RECRUITING

    Northampton, United Kingdom

    Contact

  • Northwick Park Hospital

    RECRUITING

    London, United Kingdom

    Contact

  • Nottingham University Hospitals NHS Trust

    NOT_YET_RECRUITING

    Nottingham, United Kingdom

    Contact

  • Queen Alexandra Hospital

    RECRUITING

    Portsmouth, United Kingdom

    Contact

  • Queen Elizabeth Hospital

    RECRUITING

    Birmingham, United Kingdom

    Contact

  • Royal Derby Hospital

    RECRUITING

    Derby, United Kingdom

    Contact

  • Royal Devon and Exeter Hospital

    RECRUITING

    Exeter, United Kingdom

    Contact

  • Royal United Hospital

    NOT_YET_RECRUITING

    Bath, United Kingdom

    Contact

  • Sheffield Teaching Hospitals

    RECRUITING

    Sheffield, United Kingdom

    Contact

  • St George's Hospital

    RECRUITING

    London, United Kingdom

    Contact

  • The Royal Marsden Hospitals

    RECRUITING

    London, United Kingdom

    Contact

  • University College London Hospital

    NOT_YET_RECRUITING

    London, United Kingdom

    Contact

  • University Hospital of Wales

    RECRUITING

    Cardiff, United Kingdom

    Contact

  • University Hospitals Bristol and Weston NHS Foundation Trust

    RECRUITING

    Bristol, United Kingdom

    Contact

  • University Hospitals Dorset NHS Foundation Trust

    RECRUITING

    Poole, United Kingdom

    Contact