Less surgery may be just as good for Low-Risk thyroid cancer

NCT ID NCT05604963

Recruiting now Disease control Sponsor: University College, London Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two surgical options for people with low-risk differentiated thyroid cancer: removing only part of the thyroid (hemithyroidectomy) or the entire gland (total thyroidectomy). The goal is to see if the less extensive surgery is as effective at preventing cancer recurrence while causing fewer side effects. About 456 participants will be followed for up to 6 years after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: surgical procedure (hemithyroidectomy or total thyroidectomy)
What this could lead to: If successful, this could show that removing only part of the thyroid is a safe and cost-effective option for low-risk thyroid cancer, reducing complications from full removal.
What could go wrong: This is a non-inferiority trial, meaning it aims to prove that less surgery is not worse than more surgery. It may still show higher recurrence rates with partial removal, and results may not apply to higher-risk cancers.

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Conditions

The condition(s) this trial relates to.

differentiated thyroid carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFERENTIATED THYROID CANCER

Contacts and locations

Locations

Addenbrooke's Hospital
RECRUITING

Cambridge, United Kingdom
Colchester Hospital
RECRUITING

Colchester, United Kingdom
Derriford Hospital
RECRUITING

Plymouth, United Kingdom
Forth Valley Royal Hospital
RECRUITING

Falkirk, United Kingdom
Glan Clwyd Hospital (Betsi Cadwaladr University Health Board)
RECRUITING

Rhyl, United Kingdom
Guy's Hospital
RECRUITING

London, United Kingdom
Ipswich Hospital
RECRUITING

Ipswich, United Kingdom
Leicester Royal Infirmary
RECRUITING

Leicester, United Kingdom
Leighton Hospital
RECRUITING

Crewe, Cheshire, CW1 4QJ, United Kingdom
Lister Hospital
RECRUITING

London, United Kingdom
Liverpool University Hospitals
RECRUITING

Liverpool, United Kingdom
Luton and Dunstable University Hospital
RECRUITING

Luton, United Kingdom
Medway Maritime Hospital
RECRUITING

Gillingham, United Kingdom
Musgrove Park Hospital
RECRUITING

Taunton, United Kingdom
NHS Greater Glasgow & Clyde
RECRUITING

Glasgow, United Kingdom
NHS Lothian
RECRUITING

Edinburgh, United Kingdom
Ninewells Hospital
RECRUITING

Dundee, United Kingdom
Norfolk and Norwich University Hospital
RECRUITING

Norwich, United Kingdom
Northampton General Hospital
RECRUITING

Northampton, United Kingdom
Northwick Park Hospital
RECRUITING

London, United Kingdom
Nottingham University Hospitals NHS Trust
NOT_YET_RECRUITING

Nottingham, United Kingdom
Queen Alexandra Hospital
RECRUITING

Portsmouth, United Kingdom
Queen Elizabeth Hospital
RECRUITING

Birmingham, United Kingdom
Royal Derby Hospital
RECRUITING

Derby, United Kingdom
Royal Devon and Exeter Hospital
RECRUITING

Exeter, United Kingdom
Royal United Hospital
NOT_YET_RECRUITING

Bath, United Kingdom
Sheffield Teaching Hospitals
RECRUITING

Sheffield, United Kingdom
St George's Hospital
RECRUITING

London, United Kingdom
The Royal Marsden Hospitals
RECRUITING

London, United Kingdom
University College London Hospital
NOT_YET_RECRUITING

London, United Kingdom
University Hospital of Wales
RECRUITING

Cardiff, United Kingdom
University Hospitals Bristol and Weston NHS Foundation Trust
RECRUITING

Bristol, United Kingdom
University Hospitals Dorset NHS Foundation Trust
RECRUITING

Poole, United Kingdom

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