DIFFERENTIATED THYROID CANCER

This study tests whether giving targeted drugs before radioactive iodine (RAI) can make thyroid cancer cells absorb more RAI, potentially improving treatment. It includes 32 children and young adults with advanced thyroid cancer that has spread to the lungs. The goal is to see if…

This study looks at whether removing only half of the thyroid (hemithyroidectomy) is as safe and effective as removing the whole thyroid (total thyroidectomy) for people with low-risk thyroid cancer. About 456 adults will take part and be followed for 6 years to check for cancer …

This study tests a new experimental drug (PF-07799544) combined with another drug (PF-07799933) in adults with advanced solid tumors that have a specific gene change called BRAF V600. The goal is to see if the combination is safe and can shrink or control the cancer. Participants…

This study tests whether giving a drug called selpercatinib for 6 months before radioactive iodine therapy can improve treatment outcomes in children, teens, and young adults (ages 2-25) with a specific genetic form of thyroid cancer (RET fusion). The goal is to make the cancer a…

This study is testing whether a drug called larotrectinib can make radioactive iodine therapy more effective for people with advanced thyroid cancer that has spread to the lungs. The goal is to see if taking larotrectinib before standard radioactive iodine treatment helps shrink …

This study compares a new PET imaging agent, F-18 TFB, with the standard FDG PET/CT to find leftover thyroid cancer in 50 patients who have had surgery and radioactive iodine therapy. Participants have high levels of thyroglobulin (Tg) in their blood, which may signal cancer, but…

This study aims to create a simple tool (a nomogram) that doctors can use before surgery to predict how difficult a specific type of thyroid cancer surgery (transoral and submental thyroidectomy) will be. Researchers will study 500 patients with differentiated thyroid cancer to f…

This study tests the drug pembrolizumab in people with high-risk thyroid cancer before they have surgery. The goal is to see how the drug affects immune cells in the tumor and blood. About 25 adults will take part. This is a phase 2 trial, so it is still early, but it may help do…

This study looks at how a 7-day low iodine diet changes the amount of radioactive iodine absorbed by the body in people who have had their thyroid removed due to thyroid cancer. Twenty-five adults will have their iodine uptake measured before and after the diet. The goal is to un…