New pill combo takes on Hard-to-Treat cancers

NCT ID NCT05538130

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 8 times

Summary

This early-stage trial tests two experimental pills (PF-07799544 and PF-07799933) taken twice daily at home by adults with advanced solid tumors that have a specific gene change called BRAF V600. The study aims to find safe doses and see if the drugs can shrink tumors. About 124 participants will be enrolled, and treatment continues as long as it works or side effects are manageable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PF-07799544 (ARRY-134) and PF-07799933 (ARRY-440) tablets
What this could lead to: If it works, this could point toward a new treatment option for people with advanced BRAF-mutant cancers that have stopped responding to other therapies.
What could go wrong: This is a very early Phase 1 trial with only 124 participants, so safety and effectiveness are not yet proven. The drug combo may cause side effects or fail to shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm cancer colorectal cancer differentiated thyroid carcinoma glioma low grade glioma malignant glioma melanoma metastatic malignant neoplasm neoplasm non-small cell lung carcinoma pediatric high-grade glioma T-cell large granular lymphocyte leukemia thyroid cancer Thyroid Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED OR METASTATIC SOLID TUMORS BRAIN NEOPLASMS COLORECTAL CANCER DIFFERENTIATED THYROID CANCER GLIOMA HGG HIGH GRADE GLIOMA LGG LOW GRADE GLIOMA MALIGNANT NEOPLASMS MELANOMA NON-SMALL CELL LUNG CANCER NSCLC (NON-SMALL CELL LUNG CANCER) THYROID CANCER

Contacts and locations

Locations

ANIMI - Unidade de Tratamento Oncologico
RECRUITING

Lages, Santa Catarina, 88501001, Brazil
Alberta Health Services and The Governors of The University of Alberta
RECRUITING

Edmonton, Alberta, T6G 2C8, Canada
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Brigitte Harris Cancer Pavilion
RECRUITING

Detroit, Michigan, 48202, United States
CUIMC Research Pharmacy
RECRUITING

New York, New York, 10032, United States
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus
RECRUITING

Québec, Quebec, G1J 1Z4, Canada
Centro de Oncologia - CEON+ - Unidade São Caetano do Sul
RECRUITING

São Caetano do Sul, 09541-270, Brazil
Cleveland Clinic Taussig Cancer Center
RECRUITING

Cleveland, Ohio, 44195, United States
Cleveland Clinic Taussig Cancer Center Investigational Pharmacy
RECRUITING

Cleveland, Ohio, 44106, United States
Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States
Columbia University Medical Center - Neurological Institute of New York
RECRUITING

New York, New York, 10032, United States
Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Fujian Cancer Hospital
RECRUITING

Fuzhou, Fujian, 350014, China
Hadassah Medical Center
NOT_YET_RECRUITING

Jerusalem, Jerusalem, 9112001, Israel
HealthPartners Cancer Center at regions Hospital
NOT_YET_RECRUITING

Saint Paul, Minnesota, 55101, United States
HealthPartners Frauenshuh Cancer Center
NOT_YET_RECRUITING

Saint Louis Park, Minnesota, 55426, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Highlands Oncology Group, PA
RECRUITING

Fayetteville, Arkansas, 72703, United States
Highlands Oncology Group, PA
RECRUITING

Rogers, Arkansas, 72758, United States
Highlands Oncology Group, PA
RECRUITING

Springdale, Arkansas, 72762, United States
Hospital Nossa Senhora da Conceição
RECRUITING

Porto Alegre, Rio Grande do Sul, 91350-200, Brazil
IBCC - Núcleo de Pesquisa e Ensino
RECRUITING

São Paulo, 04014-002, Brazil
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Kansai Medical University Hospital
RECRUITING

Hirakata, Osaka, 573-1191, Japan
Keck Hospital of USC
NOT_YET_RECRUITING

Los Angeles, California, 90033, United States
Keck Medical Center of USC Pasadena
NOT_YET_RECRUITING

Pasadena, California, 91105, United States
Laura & Isaac Perlmutter Cancer Center - NYU ACC
RECRUITING

New York, New York, 10016, United States
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Los Angeles General Medical Center
NOT_YET_RECRUITING

Los Angeles, California, 90033, United States
MSK Basking Ridge.
RECRUITING

Basking Ridge, New Jersey, 07920, United States
MSK Bergen.
RECRUITING

Montvale, New Jersey, 07645, United States
MSK Commack.
RECRUITING

Commack, New York, 11725, United States
MSK Monmouth.
RECRUITING

Middletown, New Jersey, 07748, United States
MSK Nassau.
RECRUITING

Uniondale, New York, 11553, United States
MSK Westchester.
RECRUITING

Harrison, New York, 10604, United States
Mass General Waltham
RECRUITING

Waltham, Massachusetts, 02451, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
McGill University Health Centre
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Memorial Sloan Kettering Cancer Center - Main Campus
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center 53rd street.
RECRUITING

New York, New York, 10022, United States
Methodist Hospital Inpatient Pharmacy
NOT_YET_RECRUITING

Saint Louis Park, Minnesota, 55426, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center
RECRUITING

Tampa, Florida, 33612, United States
Moffitt McKinley Hospital
RECRUITING

Tampa, Florida, 33612, United States
NYU Langone Faculty Group Practice
RECRUITING

New York, New York, 10016, United States
NYU Langone Medical Center (Tisch Hospital)
RECRUITING

New York, New York, 10016, United States
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
Ochsner Clinic Foundation
NOT_YET_RECRUITING

New Orleans, Louisiana, 70121, United States
Ophthalmic Consultants of Boston Inc (OCB)
RECRUITING

Boston, Massachusetts, 02114, United States
Optum Medical Care, PC
NOT_YET_RECRUITING

Brewster, New York, 10509, United States
Optum Medical Care, PC
NOT_YET_RECRUITING

Mount Kisco, New York, 10549, United States
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Providence Cancer Institute Franz Clinic
RECRUITING

Portland, Oregon, 97213, United States
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States
Rabin Medical Center
RECRUITING

Petah Tikva, Central District, 4941492, Israel
Regions Hospital Pharmacy
NOT_YET_RECRUITING

Saint Paul, Minnesota, 55101, United States
Royal Melbourne Hospital
RECRUITING

Parkville, Victoria, 3050, Australia
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Sheba Medical Center
RECRUITING

Ramat Gan, Central District, 5265601, Israel
Soroka Medical Center
RECRUITING

Beersheba, Southern District, 8410101, Israel
Sourasky Medical Center
RECRUITING

Tel Aviv, TELL ABĪB, 6423906, Israel
Sunnybrook Research Institute
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The Angeles Clinic and Research Institue, A Cedars-Sinai Affiliate (Emergency Back-up only)
RECRUITING

Santa Monica, California, 90404, United States
The Angeles Clinic and Research Institute- A Cedars-Sinai Affiliate
RECRUITING

Los Angeles, California, 90025, United States
The First Affiliated Hospital of Wenzhou Medical University
RECRUITING

Wenzhou, Zhejiang, 325000, China
The Kirklin Clinic of UAB Hospital
RECRUITING

Birmingham, Alabama, 35233, United States
The Ottawa Hospital - General Campus
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
The University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35249, United States
UCSF Helen Diller Family Comprehensive Cancer Center
RECRUITING

San Francisco, California, 94143, United States
UCSF Helen Diller Medical Center at Parnassus Heights
RECRUITING

San Francisco, California, 94143, United States
UCSF Medical Center, Investigational Pharmacy
RECRUITING

San Francisco, California, 94158, United States
UPMC Hillman Cancer Center
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
USC/Norris Comprehensive Cancer Center
NOT_YET_RECRUITING

Los Angeles, California, 90033, United States
University of Alabama at Birmingham - Phase I Clinical Trials Unit
RECRUITING

Birmingham, Alabama, 35249, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Washington Medical Center
RECRUITING

Seattle, Washington, 98195, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITING

Madison, Wisconsin, 53718, United States
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States
Zhejiang Cancer Hospital
RECRUITING

Hangzhou, Zhejiang, 310022, China

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