LOW GRADE GLIOMA

This early-stage trial tests two experimental pills (PF-07799544 and PF-07799933) taken twice daily at home by adults with advanced solid tumors that have a specific gene change called BRAF V600. The study aims to find safe doses and see if the drugs can shrink tumors. About 124 …

This early-phase study is testing the safety and how the body handles a drug called tovorafenib in Japanese children, teens, and young adults with a type of brain tumor (low-grade glioma) that has a specific genetic change (BRAF alteration) and has come back or is growing. Six pa…

This early-stage trial is testing the safety and best dose of two drugs, trametinib and everolimus, given together to children and young adults whose gliomas (a type of brain tumor) have come back after previous treatment. The study aims to find the highest dose that is safe and …

This study tests a new way to give proton radiation to children with low-grade glioma, a common brain tumor. The goal is to avoid the hippocampus, a brain area key for memory, to reduce long-term memory loss. About 74 children will receive this targeted radiation, and researchers…

This study tests whether a targeted drug called selumetinib works as well as standard chemotherapy (carboplatin and vincristine) for children and young adults with a slow-growing brain tumor called low-grade glioma. Participants must be 2 to 21 years old and have a tumor without …

This study looks at whether patients with a certain type of slow-growing brain tumor (low-grade glioma with a BRAF V600 mutation) can safely stop or reduce their dose of two targeted drugs, dabrafenib and trametinib, after 12-24 months of treatment. About 96 participants will eit…

This study is testing proton radiation as a treatment for adults with benign or slow-growing brain tumors. Researchers want to see how well it controls tumor growth and how it affects quality of life and side effects. About 100 participants will receive proton radiation and be fo…

This study tests a laser treatment called LITT for children, teens, and young adults whose low-grade brain tumors have come back or grown after prior therapy. About 40 participants will receive the laser procedure to heat and destroy tumor tissue. The main goal is to see how many…

This study tests a drug called mirdametinib in children, adolescents, and young adults with low-grade glioma, a type of brain tumor. The drug is designed to cross into the brain and block a protein that helps tumors grow. The trial has two phases: Phase 1 finds the safest dose, a…

This phase 2 trial tests a vaccine made from glioma antigen peptides combined with an immune booster (Poly-ICLC) in 25 children with recurrent low-grade gliomas that cannot be removed by surgery. The goal is to see if the vaccine can shrink tumors or keep them stable. Children wh…

This early-phase trial at Children's Hospital of Philadelphia is testing whether a radioactive tracer called 18F-Fluciclovine (Axumin) can improve PET-MRI scans for children and young adults with low-grade glioma. About 30 participants will receive the tracer before starting trea…

This study tests a new software called Wave-CAIPI that aims to speed up MRI scans for children with low-grade gliomas. Researchers will compare the fast scans to standard ones to see if they provide the same image quality. The goal is to make imaging quicker and less stressful fo…

This study tests three ways to help adults with low-grade glioma improve memory and attention: an iPad app (ReMind), daily health text messages, and in-person cognitive rehab. About 97 participants will try one of these programs for several weeks, and researchers will track their…

This study tests whether slowly reducing the dose of the steroid dexamethasone after brain tumor surgery can lower side effects like high blood sugar and poor wound healing, while still preventing brain swelling. About 200 adults with certain brain tumors will be randomly assigne…

This study tests a home-based program called HOBSCOTCH-CA for brain cancer survivors who struggle with memory and thinking. The program involves weekly virtual sessions with a coach, teaching problem-solving and relaxation techniques. Researchers will compare two groups: one that…

This study looks at low-grade gliomas, a slow-growing type of brain tumor, in Argentina. Researchers will review medical records from about 40 patients to find out how common these tumors are and how long people live after diagnosis. The goal is to better understand these tumors …

This study collects tumor samples from 50 adults with low- or high-grade glioma to grow mini-tumors (organoids) in the lab. Researchers will study these organoids to learn why gliomas are so hard to treat and how they spread. The goal is to create personalized 'avatars' for testi…

This study uses advanced MRI scans to better identify parts of brain tumors that are likely to grow back after standard treatment. Researchers will compare these scans with usual methods to see if they can improve radiation planning. About 135 adults with certain brain tumors wil…