LOW GRADE GLIOMA

This study tests a new drug called tovorafenib in Japanese children, teens, and young adults with a type of brain tumor called low-grade glioma that has a specific genetic change (BRAF alteration). The main goals are to see if the drug is safe and how the body handles it. Partici…

This study is testing a drug called mirdametinib in children, adolescents, and young adults with low-grade glioma, a type of brain tumor. The drug is designed to reach the brain and block signals that help tumors grow. The goal is to find the best dose and see if it can shrink tu…

This study tests a laser treatment called LITT for children, teens, and young adults whose low-grade brain tumors have come back or worsened after prior therapy. The goal is to stop tumor growth for at least 15 months. About 40 participants will receive the laser procedure, which…

This study looks at whether people with a slow-growing brain tumor (low-grade glioma) that has a specific gene change (BRAF V600) can safely stop or lower their dose of two targeted drugs (dabrafenib and trametinib) after taking them for 12-24 months. About 96 participants will e…

This study tests a vaccine made from proteins found on glioma cells, combined with an immune booster, in children with low-grade gliomas that cannot be removed by surgery and have returned after at least two prior treatments. The goal is to see if the vaccine can shrink the tumor…

This study tests if a targeted drug called selumetinib works as well as standard chemotherapy (carboplatin and vincristine) for children and young adults with a slow-growing brain tumor called low-grade glioma. The tumor must not have a specific gene change (BRAFV600E) or be link…

This early-phase study tests a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with solid tumors that have returned or not responded to treatment. The main goal is to find a safe dose with manageable side effects. The drugs targe…

This study tests a new experimental drug (PF-07799544) combined with another drug (PF-07799933) in adults with advanced solid tumors that have a specific gene change called BRAF V600. The goal is to see if the combination is safe and can shrink or control the cancer. Participants…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants (including veterans and civilians) will either start the program right away or wait 3 months. The program involves …

This study looks at whether slowly lowering the dose of the steroid dexamethasone after brain tumor surgery can reduce side effects like high blood sugar and slow wound healing. About 200 adults with certain brain tumors will be randomly assigned to either a standard steroid tape…

This study looks at whether special brain exercises can help adults with low-grade glioma improve memory, attention, and thinking skills that often get worse after surgery, radiation, or chemo. About 97 people will try three different rehab methods—in-person, app-based, or text m…

This study collects tumor tissue from 50 adults with low- or high-grade glioma during surgery to grow mini-tumors (organoids) in the lab. Researchers will compare these organoids with the original tumors to learn why gliomas are so hard to treat. The goal is to find new ways to p…

This study is testing whether a special PET-MRI scan using a tracer called 18F-Fluciclovine can better monitor low-grade gliomas (a type of brain tumor) in children and young adults. About 30 participants will get the scan before starting treatment, then again at 3 months and 1 y…