LOW-GRADE GLIOMA

This study is for children and young adults (1-25 years old) with a specific type of slow-growing brain tumor that has a BRAF V600 gene mutation. The goal is to see if patients who have taken the drugs dabrafenib and trametinib successfully for 12-24 months can either stop the dr…

This study is testing the safety of a new two-drug combination (avutometinib and defactinib) for children and young adults (ages 3-30) whose solid tumors have come back or stopped responding to standard treatments. The main goal is to find the highest dose that is safe and causes…

This study is testing a new oral drug called tovorafenib (DAY101) against standard chemotherapy for children and young adults with a specific type of slow-growing brain tumor. The goal is to see if the new drug is more effective at shrinking tumors and controlling the disease, an…

This early-stage trial is testing the safety and best doses of two oral drugs, trametinib and everolimus, given together to children and young adults whose brain tumors have come back after prior treatment. The study aims to see if blocking two different tumor growth pathways at …

This study is testing whether a personalized vaccine can help the immune system fight recurrent low-grade brain tumors in children and young adults. It is for patients whose tumors cannot be removed by surgery and have come back after at least two prior treatments. The main goals…

This study is for children and young adults (ages 2-21) with a specific type of slow-growing brain tumor called low-grade glioma. It compares a newer oral drug, selumetinib, to the current standard intravenous chemotherapy (carboplatin and vincristine). The main goal is to see if…

This study is testing a drug called mirdametinib for children and young adults with low-grade glioma, a type of brain tumor. The goal is to see if the drug is safe, find the right dose, and measure how well it shrinks or controls the tumor. The trial includes patients who are new…

This early-stage study is testing the safety and initial effects of a new oral medicine, PF-07799544, when taken with another drug, PF-07799933. It is for adults with advanced solid tumors, like melanoma or lung cancer, that have a specific genetic change called a BRAF V600 mutat…

This study is testing whether a new type of brain scan can help doctors better see how well treatments are working for children and young adults with low-grade brain tumors. Participants will get the special scan before starting treatment and again at 3 months and 1 year. Researc…

This study is testing different ways to help adults with low-grade brain tumors who have trouble with memory, focus, and thinking after their cancer treatments. Researchers are trying out in-person therapy, a special iPad app, and daily supportive text messages to see if they can…

This study is testing if a shorter, lower dose of steroids (dexamethasone) after brain tumor surgery can reduce side effects like high blood sugar and poor wound healing, without increasing the risk of dangerous brain swelling. It will compare a 4-day steroid schedule to the stan…

This study is testing a home-based program called HOBSCOTCH-CA, designed to help brain cancer survivors manage memory and thinking problems that often follow their illness. Participants will work one-on-one with a coach over video calls to learn problem-solving and relaxation tec…

This study aims to create a living collection of 3D models grown from patients' brain tumors (gliomas). Researchers will use these models to understand why these tumors are hard to treat, become more aggressive, and resist therapies like radiation and chemotherapy. The long-term …