LOW GRADE GLIOMA

This study compares a targeted drug called selumetinib to standard chemotherapy (carboplatin/vincristine) in children aged 2 to 21 with neurofibromatosis type 1 (NF1) and low-grade glioma, a type of brain tumor. The goal is to see if selumetinib works as well or better at control…

This early-stage study tests a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with advanced or recurrent solid tumors that have specific genetic changes. The main goal is to find the safest dose with the fewest side effects. The…

This study tests a new drug called DAY101 (tovorafenib) against standard chemotherapy for children and young adults with a type of brain tumor called low-grade glioma that has a specific gene change (RAF alteration). The goal is to see if the new drug works better at shrinking tu…

This study tests a drug called selumetinib in children and young adults with low grade glioma that has come back or not responded to other treatments. The drug works by blocking certain enzymes that help tumor cells grow. The goal is to find the best dose and see if it can shrink…

This phase 2 trial tests the drug trametinib in children and young adults (ages 1 month to 25 years) with low-grade glioma or plexiform neurofibroma that has not responded to prior treatment. Participants take a daily oral dose for up to 18 cycles. The study aims to see if the dr…

This early-phase study tests a new drug (BGB-290) combined with chemotherapy (temozolomide) in teens and young adults with a type of brain tumor called glioma that has an IDH mutation. The goal is to find the safest dose and see how well the combination works for both newly diagn…

This study compares two treatment plans for people with a specific type of brain tumor (anaplastic or low-grade glioma with 1p/19q co-deletion). One group gets radiation plus the drug temozolomide, the other gets radiation plus a different chemo combo called PCV. The goal is to s…

This study tests a precise type of radiation called proton therapy for people with slow-growing brain tumors (low-grade gliomas). The goal is to see if it can control tumor growth as well as standard radiation while causing fewer side effects by sparing healthy brain tissue. Abou…

This study tests if the immunotherapy drug nivolumab can stop or slow the growth of certain brain tumors (gliomas) that have IDH mutations. Researchers are especially interested in tumors with many genetic changes (hypermutator phenotype). The trial involves 62 adults who receive…

This study tests a combination of two drugs, cobolimab and dostarlimab, in children and young adults (up to age 21) with advanced solid tumors that have not responded to other treatments. The goal is to find the safest dose and see if the combination can shrink tumors. The study …

This phase 3 trial compares radiation therapy alone versus radiation plus the chemotherapy drug temozolomide for people with symptomatic or progressive low-grade gliomas. The study enrolled 540 adults and aims to see if adding chemo improves how long patients live without their t…

This study tests an online mind-body program designed for people with brain tumors (glioma) and their partners. The program aims to improve spiritual well-being, sleep, mood, and overall quality of life for both. Researchers are enrolling 74 couples to see if the program is pract…

This study investigates whether a simple blood test can help diagnose and monitor low-grade gliomas, a type of slow-growing brain tumor. Researchers will collect blood samples from 50 patients undergoing brain surgery to look for circulating tumor cells and other markers. The goa…

This study tracks a substance called 2-HG in the brains of people with a type of brain cancer (glioma) that has specific gene changes. By using special MRI scans over time, researchers hope to learn how and when these tumors become more aggressive. About 42 adults will have regul…

This study follows 75 adults with benign or slow-growing brain tumors who are receiving partial brain radiation. Researchers will use memory tests and MRI scans before treatment and at 6 and 12 months after to see how radiation affects thinking and memory. The goal is to identify…

This study tests a new ultrasound system (SonoClear®) that uses a special gel to mimic brain tissue, aiming to give surgeons clearer images during brain tumor removal. Fifteen adults with glioma (a type of brain tumor) are participating. The main goal is to see if the new system …

This study tests a camera that uses different colors of light to tell the difference between low-grade brain tumor tissue and normal brain tissue during surgery. Ten adults with suspected low-grade glioma will have the camera used during their tumor removal operation. The goal is…

This study looks at how seizures change over time in people with low grade glioma (a slow-growing brain tumor) who are on treatment. By tracking seizure frequency and comparing it to MRI scans, researchers hope to find early signs of tumor changes. The goal is to help doctors det…

This early-stage trial enrolls 16 adults with recurrent IDH-mutant gliomas who are scheduled for surgery. Participants take niraparib for one month before their operation so researchers can measure how much drug reaches the tumor and how it affects cancer cells. The goal is to ga…