LOW-GRADE GLIOMA

This study tested a drug called selumetinib for children and young adults whose low-grade brain tumors came back or didn't respond to prior treatment. The goal was to find a safe dose and see if the drug could shrink or control the tumors. Participants took the drug as a pill twi…

This study is testing whether the immunotherapy drug nivolumab can help control the growth of certain brain tumors (gliomas) that have specific genetic changes. It is enrolling 62 adults whose tumors have either a very high number of mutations or a normal number. The main goal is…

This study is for children and young adults (ages 2-21) with a genetic condition called Neurofibromatosis Type 1 (NF1) who have a low-grade brain tumor. It compares a newer oral medication called selumetinib against the standard intravenous chemotherapy (carboplatin/vincristine).…

This study is testing whether proton radiation therapy can effectively control the growth of certain types of brain tumors while causing fewer side effects than standard radiation. Proton radiation delivers energy more precisely to the tumor, potentially sparing surrounding healt…

This early-stage study is testing a new two-drug combination (BGB-290 and temozolomide) for adolescents and young adults with specific types of brain tumors that have returned or are newly diagnosed. The main goal is to find the safest dose and understand the side effects. Resear…

This study is testing an online meditation and breathing program designed for couples where one person has a brain tumor. The goal is to see if the program is practical and helps improve spiritual well-being, sleep, mood, and overall quality of life for both the patient and their…

This early study aims to understand if an experimental drug called niraparib reaches brain tumor tissue effectively. It involves 16 adults with recurrent, slow-growing brain tumors (gliomas) who are already scheduled for surgery. Researchers will measure how much of the drug gets…

This study aims to understand if changes in seizure frequency can serve as an early sign of how well a brain tumor is responding to treatment. It involves 100 adults with low-grade glioma who have a history of seizures. Participants complete a short survey about their seizures at…

This study aims to understand how certain brain tumors change and become more aggressive over time. Researchers will use special brain scans to track chemical levels in the tumors of adults with specific genetic mutations. The goal is to learn if these chemical changes can signal…