LOW GRADE GLIOMA

This study tests a precise type of radiation called proton therapy for people with low-grade or certain grade 3 brain tumors (gliomas). The goal is to see if it can control tumor growth as well as standard radiation while causing fewer side effects by sparing healthy brain tissue…

This early-stage trial is testing the safety and best dose of two drugs, trametinib and everolimus, given together to children and young adults whose gliomas (a type of brain tumor) have come back after prior treatment. The study aims to find the highest dose that causes fewest s…

This study tests the drug nivolumab in 62 adults with a type of brain tumor (glioma) that has specific gene changes (IDH mutations). The goal is to see if nivolumab can stop or slow tumor growth. Participants receive the drug through an IV every few weeks and are monitored with s…

This study tests a new drug called DAY101 (tovorafenib) against standard chemotherapy for children and young adults with a type of brain tumor called low-grade glioma that has a specific genetic change (RAF alteration). The goal is to see if the new drug works better at shrinking…

This early-stage study tests a new drug (BGB-290) combined with chemotherapy (temozolomide) in adolescents and young adults with IDH-mutant gliomas, a type of brain tumor. The goal is to find the safest dose and check for side effects. About 78 participants with newly diagnosed o…

This study tests whether the targeted drug selumetinib works as well as standard chemotherapy (carboplatin/vincristine) for children and young adults (ages 2-21) with NF1-related low-grade glioma. The goal is to see if selumetinib can stop tumor growth and improve vision better t…

This study tests a drug called selumetinib in children and young adults with a slow-growing brain tumor (low grade glioma) that has come back or not responded to other treatments. The goal is to find the best dose and see how well it shrinks or stabilizes the tumor. About 217 par…

This study tests an online mind-body program for people with brain tumors (glioma or cancer spread to the brain) and their partners. The program aims to improve spiritual well-being, sleep, mood, and overall quality of life. About 74 couples will take part to see if the program i…

This early-phase trial is studying how the drug niraparib gets into brain tumor tissue and affects it in 16 adults with recurrent IDH-mutant gliomas. Participants take niraparib for about a month before their scheduled surgery, then researchers measure drug levels and activity in…

This study looks at how seizures change over time in 100 adults with low grade glioma who are receiving treatment. By comparing seizure patterns with brain scans, researchers hope to find early signs of tumor changes. The goal is to help doctors detect problems sooner and improve…

This study looks at people with a type of brain cancer called glioma that has a specific gene change (IDH mutation). Researchers use special MRI scans to measure a substance called 2-HG in the brain over time, which may show when the tumor becomes more aggressive. The goal is to …