New hope for young brain tumor patients: drug combo targets IDH mutations
NCT ID NCT03749187
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tests a new drug (BGB-290) combined with chemotherapy (temozolomide) in teens and young adults with a type of brain tumor called glioma that has an IDH mutation. The goal is to find the safest dose and see how well the combination works for both newly diagnosed and recurrent tumors. About 78 participants will be enrolled.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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University of California, San Francisco
San Francisco, California, 94143, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Yale University
New Haven, Connecticut, 06520, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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