WHO GRADE III GLIOMA
Clinical trials for WHO GRADE III GLIOMA explained in plain language.
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Promising drug cocktail targets tough brain cancers in kids
Disease control Recruiting nowThis study tests two drug combinations given after radiation for children and young adults with aggressive brain tumors (high-grade glioma or DIPG). One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The goal is to see if these combinations …
Matched conditions: WHO GRADE III GLIOMA
Phase: PHASE2 • Sponsor: Nationwide Children's Hospital • Aim: Disease control
Last updated May 16, 2026 23:49 UTC
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New drug hope for kids with rare brain tumors
Disease control Recruiting nowThis study tests the drug lorlatinib in children (ages 1 to 21) with a newly diagnosed high-grade glioma that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor and to check its safety when given with or after other …
Matched conditions: WHO GRADE III GLIOMA
Phase: EARLY_PHASE1 • Sponsor: Nationwide Children's Hospital • Aim: Disease control
Last updated May 16, 2026 23:47 UTC
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New hope for kids with rare brain tumors: adaptive trial tests drug cocktails
Disease control Recruiting nowThis study tests whether combining the drug ONC201 with other new agents can help children and young adults with diffuse midline gliomas (DMGs), including DIPG. The trial uses an adaptive design, meaning new drug combinations can be added as research evolves. About 360 participan…
Matched conditions: WHO GRADE III GLIOMA
Phase: PHASE2 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated May 15, 2026 11:56 UTC
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New combo therapy targets aggressive brain tumors in phase 2 trial
Disease control Recruiting nowThis study tests a more intense treatment for a fast-growing type of brain cancer called IDH wildtype glioma. It combines higher doses of radiation with the chemotherapy drug temozolomide to try to stop the tumor from growing longer. The trial will enroll 40 adults with this spec…
Matched conditions: WHO GRADE III GLIOMA
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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Personalized video aims to calm brain cancer patients and caregivers during radiation
Symptom relief Recruiting nowThis study tests whether a custom video that shows symptoms specific to a patient's brain tumor can lower anxiety during radiation treatment. About 117 patients with newly diagnosed gliomas and their caregivers will take part. The video is made from the patient's own MRI scan and…
Matched conditions: WHO GRADE III GLIOMA
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated May 16, 2026 23:49 UTC
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Brain tumor genetics could unlock personalized treatments for kids
Knowledge-focused Recruiting nowThis study is for children, teens, and young adults (ages 1 to 39) newly diagnosed with a high-grade glioma, a serious type of brain tumor. Researchers will analyze the tumor's genetic makeup to see if it matches a specific treatment plan in a future study. The goal is to learn m…
Matched conditions: WHO GRADE III GLIOMA
Sponsor: Nationwide Children's Hospital • Aim: Knowledge-focused
Last updated May 16, 2026 23:47 UTC
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New imaging study seeks to unlock secrets of brain tumor metabolism
Knowledge-focused Recruiting nowThis study is testing a special type of MRI scan to see how well it can track changes in lower grade brain tumors. Researchers will scan about 300 people with these tumors to measure metabolic activity in the brain. The goal is to learn if this imaging method can help doctors bet…
Matched conditions: WHO GRADE III GLIOMA
Phase: PHASE1 • Sponsor: Susan Chang • Aim: Knowledge-focused
Last updated May 08, 2026 12:00 UTC