New MRI technique could reveal hidden brain tumor activity

NCT ID NCT04540107

Recruiting now Knowledge-focused Sponsor: Susan Chang Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new type of MRI scan that uses a special substance (hyperpolarized 13C pyruvate) to see how brain tumors use energy. Researchers want to know if this scan is safe and can show changes in tumor metabolism over time. About 300 people with low-grade gliomas will be scanned to help improve how these tumors are monitored and treated.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hyperpolarized Carbon C 13 Pyruvate
What this could lead to: If successful, this imaging technique could help doctors better detect and monitor brain tumors, leading to more personalized treatment decisions.
What could go wrong: This is an early phase 1 study focused on safety and imaging feasibility, not treatment. The technique may not prove useful for routine care, and there is a small risk of side effects from the injected substance.

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Conditions

The condition(s) this trial relates to.

glioma grade II glioma grade III glioma low grade glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT WHO GRADE III GLIOMA RECURRENT WORLD HEALTH ORGANIZATION (WHO) GRADE II GLIOMA WHO GRADE II GLIOMA WHO GRADE III GLIOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States

Contact Email: •••••@•••••

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