New hope for young brain cancer patients: targeted drug combo enters phase 2 trial
NCT ID NCT06161974
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding the drug olutasidenib to standard chemotherapy (temozolomide) can help children and young adults with a specific type of brain cancer (IDH1-mutant high-grade glioma) live longer. About 60 participants will receive the combination as maintenance therapy after radiation. The goal is to slow or stop the cancer from growing, but ongoing treatment is needed, so this is not a cure.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
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Children's Hospital Colorado
NOT_YET_RECRUITINGAurora, Colorado, 80045, United States
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Children's Hospital of Philadelphia
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's National Medical Center
NOT_YET_RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
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Duke University Health System
RECRUITINGDurham, North Carolina, 27708, United States
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Great Ormond Street Hospital
NOT_YET_RECRUITINGLondon, WC1N 3JH, United Kingdom
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Hopp Children's Cancer Center at NCT Heidelberg (KiTZ)
NOT_YET_RECRUITINGHeidelberg, Baden-Wurttemberg, 69120, Germany
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Montreal Children's Hospital
NOT_YET_RECRUITINGMontreal, Quebec, H4A3J1, Canada
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43235, United States
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Perth Children's Hospital
RECRUITINGPerth, Western Australia, 6000, Australia
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Princess Máxima Center
NOT_YET_RECRUITINGUtrecht, 3720, Netherlands
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Queensland Children's Hospital
NOT_YET_RECRUITINGSouth Brisbane, Queensland, 4101, Australia
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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Starship Children's Hospital
NOT_YET_RECRUITINGAuckland, Grafton, 1023, New Zealand
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Susan Chi
NOT_YET_RECRUITINGBoston, Massachusetts, 02215, United States
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Sydney Children's Hospital
RECRUITINGRandwick, New South Wales, 2031, Australia
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Texas Children's Hospital
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
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The Hospital for Sick Children (SickKids)
NOT_YET_RECRUITINGToronto, Ontario, M5G1X8, Canada
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University of Miami Hospital and Clinics
RECRUITINGMiami, Florida, 33136, United States
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