Could cutting a wider margin around brain tumors extend survival?

NCT ID NCT04737577

Completed Disease control Sponsor: Sunnybrook Health Sciences Centre Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This pilot trial asks whether removing a wider margin of brain tissue around a high-grade glioma—beyond the standard visible tumor boundary—can improve survival without causing more neurological harm. It enrolls adults with a first-time diagnosis of high-grade glioma in a surgically safe location. Participants are randomly assigned to either standard removal of the enhancing tumor or a supra-marginal resection that extends at least 1 cm into surrounding tissue. The study primarily tests whether a larger trial is feasible, while also tracking survival, neurological function, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Supra-marginal surgical resection (removing a wider margin of brain tissue around the tumor)
What this could lead to: If successful, this could show that a wider surgical margin improves survival for people with high-grade glioma, potentially changing standard surgical practice.
What could go wrong: This is a small pilot study focused on feasibility, not a definitive test of survival benefit. Removing more brain tissue may increase the risk of neurological problems, and results may not apply to all glioma patients.

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Conditions

The condition(s) this trial relates to.

brain cancer glioma malignant glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH GRADE GLIOMA

Contacts and locations

Locations

Kingston Health Sciences Centre

Kingston, Ontario, K7L 2V7, Canada
Mackenzie Health Sciences Center

Edmonton, Alberta, T6G 2B7, Canada
St Michael's Hospital

Toronto, Ontario, M5B 1W8, Canada
Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada
The Pennsylvania State University

University Park, Pennsylvania, 16802, United States
University of Saskatchewan

Saskatoon, Saskatchewan, Canada

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