WHO GRADE IV GLIOMA
Clinical trials for WHO GRADE IV GLIOMA explained in plain language.
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Targeted drug lorlatinib tested in kids with rare brain tumors
Disease control Recruiting nowThis early-phase study tests the drug lorlatinib in children and young adults (ages 1 to 21) with newly diagnosed high-grade glioma, a fast-growing brain tumor, that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor…
Matched conditions: WHO GRADE IV GLIOMA
Phase: EARLY_PHASE1 • Sponsor: Nationwide Children's Hospital • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
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New hope for kids with deadly brain tumors: combination drug trial launches
Disease control Recruiting nowThis phase 2 trial is testing whether combining the drug ONC201 with other treatments (like paxalisib or a cancer-killing virus called DNX-2401) can help children and young adults with diffuse midline gliomas, a rare and aggressive brain cancer. The study enrolls 360 participants…
Matched conditions: WHO GRADE IV GLIOMA
Phase: PHASE2 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
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New hope for young brain cancer patients: targeted drug combo enters phase 2 trial
Disease control Recruiting nowThis study tests whether adding the drug olutasidenib to standard chemotherapy (temozolomide) can help children and young adults with a specific type of brain cancer (IDH1-mutant high-grade glioma) live longer. About 60 participants will receive the combination as maintenance the…
Matched conditions: WHO GRADE IV GLIOMA
Phase: PHASE2 • Sponsor: Rigel Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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New hope for kids with aggressive brain cancer: targeted drug combo trial launches
Disease control Recruiting nowThis study tests whether adding two different drug combinations after radiation can help children and young adults (up to age 21) with high-grade gliomas, including DIPG, live longer. One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The go…
Matched conditions: WHO GRADE IV GLIOMA
Phase: PHASE2 • Sponsor: Nationwide Children's Hospital • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Brain tumor DNA test could match kids to smarter treatments
Knowledge-focused Recruiting nowThis study uses genetic testing of brain tumors from children, adolescents, and young adults (ages 1 to 39) with newly diagnosed high-grade glioma, including DIPG. The goal is to identify specific genetic changes in each tumor and then see if patients can join a treatment trial t…
Matched conditions: WHO GRADE IV GLIOMA
Sponsor: Nationwide Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC