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Targeted drug lorlatinib tested in kids with rare brain tumors

NCT ID NCT06333899

Recruiting now Disease control Sponsor: Nationwide Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This early-phase study tests the drug lorlatinib in children and young adults (ages 1 to 21) with newly diagnosed high-grade glioma, a fast-growing brain tumor, that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor and to check its safety when given alone, with chemotherapy, or after radiation. Only 15 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Lorlatinib (a targeted cancer drug, also known as LOBRENA)
What this could lead to
If it works, this could point toward a targeted treatment option for children with rare, aggressive brain tumors that have specific genetic changes.
What could go wrong
This is a very early, small pilot study with only 15 participants, so results may not apply broadly. The drug may cause side effects or fail to control the tumor long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anaplastic astrocytoma astrocytoma (excluding glioblastoma) diffuse intrinsic pontine glioma diffuse midline glioma, H3 K27-altered glioblastoma glioma glioma susceptibility 1 grade III glioma infant-type hemispheric glioma malignant glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANAPLASTIC ASTROCYTOMA DIFFUSE INTRINSIC PONTINE GLIOMA DIFFUSE MIDLINE GLIOMA, H3K27-ALTERED GLIOBLASTOMA GLIOBLASTOMA MULTIFORME HIGH GRADE GLIOMA INFANT TYPE HEMISPHERIC GLIOMA WHO GRADE III GLIOMA WHO GRADE IV GLIOMA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Ann & Robert H. Lurie Children's Hospital of Chicago

    NOT_YET_RECRUITING

    Chicago, Illinois, 60611, United States

    Contact Email: •••••@•••••

  • Children's Hospital Colorado

    NOT_YET_RECRUITING

    Aurora, Colorado, 80045, United States

    Contact Email: •••••@•••••

  • Children's Hospital of Philadelphia

    NOT_YET_RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact Email: •••••@•••••

  • Children's National Medical Center

    NOT_YET_RECRUITING

    Washington D.C., District of Columbia, 20010, United States

    Contact Email: •••••@•••••

  • Cincinnati Children's Hospital Medical Center

    RECRUITING

    Cincinnati, Ohio, 45229, United States

    Contact Email: •••••@•••••

  • Dana-Farber Cancer Institute

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02215, United States

    Contact Email: •••••@•••••

  • Duke University Health System

    NOT_YET_RECRUITING

    Durham, North Carolina, 27708, United States

    Contact Email: •••••@•••••

  • Hopp Children's Cancer Center at NCT Heidelberg (KiTZ)

    NOT_YET_RECRUITING

    Heidelberg, Baden-Wurttemberg, 69120, Germany

    Contact Email: •••••@•••••

  • Montreal Children's Hospital

    NOT_YET_RECRUITING

    Montreal, Quebec, H4A3J1, Canada

    Contact Email: •••••@•••••

  • Nationwide Children's Hospital

    RECRUITING

    Columbus, Ohio, 43235, United States

    Contact Email: •••••@•••••

  • Perth Children's Hospital

    NOT_YET_RECRUITING

    Perth, Western Australia, 6000, Australia

    Contact Email: •••••@•••••

  • Princess Máxima Center

    NOT_YET_RECRUITING

    Utrecht, 3720, Netherlands

    Contact Email: •••••@•••••

  • Queensland Children's Hospital

    NOT_YET_RECRUITING

    South Brisbane, Queensland, 4101, Australia

    Contact Email: •••••@•••••

  • Seattle Children's Hospital

    NOT_YET_RECRUITING

    Seattle, Washington, 98105, United States

    Contact Email: •••••@•••••

  • Starship Children's Hospital

    NOT_YET_RECRUITING

    Auckland, Grafton, 1023, New Zealand

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sydney Children's Hospital

    NOT_YET_RECRUITING

    Randwick, New South Wales, 2031, Australia

    Contact Email: •••••@•••••

  • Texas Children's Hospital

    NOT_YET_RECRUITING

    Houston, Texas, 77030, United States

    Contact Email: •••••@•••••

  • The Hospital for Sick Children (SickKids)

    NOT_YET_RECRUITING

    Toronto, Ontario, M5G1X8, Canada

    Contact Email: •••••@•••••

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