GLIOBLASTOMA

This is a first-in-human study to find the safest dose of a new oral drug called ONC206 for children and young adults with aggressive brain tumors, including a type called diffuse midline glioma (DMG). The trial will test the drug alone or in combination with radiation therapy in…

This study aims to find out if performing a second brain surgery when an aggressive brain tumor (glioblastoma) comes back helps patients live longer and maintain a better quality of life. It will compare two groups: one that has surgery followed by standard drug therapy, and anot…

This study is testing a new treatment approach for a very aggressive type of brain cancer called glioblastoma. The goal is to see if giving a higher dose of radiation, along with a drug (bevacizumab) meant to protect healthy tissue, can help patients live longer without causing s…

This early-stage trial is testing a new injection called VRT106 in patients whose glioblastoma, a fast-growing brain cancer, has returned or gotten worse. The main goals are to find a safe dose and see if the treatment shows any early signs of helping. The study will enroll 42 ad…

This early-stage trial is testing a new drug called RMC-5552 in adults whose aggressive brain cancer (glioblastoma) has returned after standard treatment. The main goals are to find the safest and most effective dose and to see if the drug can help shrink tumors. The study will e…

This study is testing whether adding a substance called silibinin to the standard treatment for a fast-growing brain cancer (glioblastoma) can help control the disease for a longer period. About 110 adults with newly diagnosed cancer that has a specific marker (STAT3-positive) wi…

This early-stage study is testing a new, personalized cancer vaccine for people newly diagnosed with glioblastoma, a fast-growing brain tumor. The vaccine is custom-made for each patient using proteins from their own tumor, with the goal of training their immune system to attack …

This is a first-in-human study testing a new cell therapy called CARv3-TEAM-E for glioblastoma, an aggressive brain cancer. Researchers will collect a patient's own immune cells, genetically modify them to target cancer, and reinfuse them to see if they can safely fight the tumor…

This is a first-in-human study testing a new experimental drug called 212Pb-DOTAM-GRPR1 in adults with advanced cancers that have returned or spread. The main goal is to find a safe and tolerable dose. Researchers will also check if the drug, which delivers radiation directly to …

This study is testing a new type of cell therapy for people with advanced solid tumors that have stopped responding to standard treatments. Doctors will analyze a patient's tumor to select a specific target, then infuse specially engineered immune cells (CAR-NK cells) from a heal…

This early-stage study is testing a new combination treatment for adults with aggressive brain cancer that has returned after prior therapy. After surgeons remove as much tumor as possible, a modified virus is injected into the area to target remaining cancer cells. The main goal…

This early-stage study is testing a new personalized treatment for adults with a specific type of recurrent brain cancer called glioblastoma. Doctors take a patient's own immune cells, genetically modify them in a lab to better target the cancer, and then infuse them back into th…

This study is testing if a special food-grade egg yolk powder called Salovum® can help control glioblastoma, a very aggressive brain cancer. Researchers will measure pressure and inflammation inside the tumors of 10 patients before and after they take the powder, following a stan…

This study is testing a combination of three drugs—pembrolizumab, olaparib, and temozolomide—to see if they can help control recurrent glioblastoma, an aggressive brain tumor that has returned after initial treatment. The trial will enroll about 78 adults whose cancer has come ba…

This study is testing if a special type of PET scan (FDOPA-PET) can help doctors aim a second round of radiation therapy more precisely at recurrent glioblastoma, a very aggressive brain cancer. The goal is to see if delivering a higher, more focused dose to the exact tumor area …

This program provides access to an investigational drug called ulixertinib for patients with advanced cancers that have specific genetic changes (MAPK pathway mutations). It is for people who have run out of other treatment options. The drug aims to control the cancer's growth, e…

This study is testing whether a more intensive combination of radiation therapy and chemotherapy can better control certain aggressive brain tumors. It will involve about 40 adults with specific types of fast-growing brain cancer. Researchers aim to see if this stronger treatment…

This study is testing if a new, non-invasive ultrasound device, used with a light-sensitive drug, can help control a fast-growing brain cancer called glioblastoma. After standard surgery and chemo-radiation, about 100 patients will be randomly assigned to receive either the real …

This study is testing a new way to treat glioblastoma, a very aggressive brain cancer. During surgery to remove the main tumor, doctors will place a special balloon in the empty space and deliver a single dose of radiation directly to the area. After recovering, patients will rec…

This study is testing whether adding the drug ruxolitinib to the standard treatment (radiation plus temozolomide) works better for people newly diagnosed with glioblastoma, a serious type of brain cancer. About 190 adults will be randomly assigned to receive either the standard t…

This trial is testing if adding a cannabis-based mouth spray (Nabiximols) to standard chemotherapy (temozolomide) helps people with a specific type of recurrent brain tumor (glioblastoma) live longer. About 120 participants will be randomly assigned to receive either the real can…

This is a first-in-human study testing a new type of cell therapy for adults with recurrent or progressive glioblastoma or other high-grade brain tumors. The therapy uses modified natural killer (NK) immune cells designed to recognize two specific markers on the patient's tumor. …

This study is testing whether adding a drug called ibrutinib to an existing experimental treatment can help the body's immune system fight brain cancer more effectively. It is for children and young adults (ages 6-25) whose brain cancer has come back or hasn't responded to standa…

This study is testing if methimazole, a drug normally used for thyroid conditions, can help control the growth of glioblastoma, an aggressive brain cancer. Researchers believe the drug might work by boosting the body's natural production of a protective compound called hydrogen s…

This study is testing several combination treatments for adults whose glioblastoma brain cancer has returned or progressed after initial treatment. The trial has two parts: one testing three drugs together, and another comparing two different combinations that include a special c…

This study aims to find out if the cancer drug trastuzumab deruxtecan (T-DXd) can get into brain tumors when given through an IV. Researchers will measure how much of the drug reaches the tumor during surgery in 30 adults with certain HER2-positive brain cancers or recurrent glio…

This early-stage study is testing the safety of a radioactive drug called 131I-TLX101 when added to standard treatment for newly diagnosed glioblastoma, an aggressive brain cancer. Researchers will give increasing doses to 12 patients who have recently had surgery but haven't sta…

This study aims to find better treatments for children and young adults newly diagnosed with aggressive brain tumors. Researchers will analyze the genetic makeup of each patient's tumor to match them with a targeted therapy that might work best for their specific cancer. The goal…

This early-stage study is testing the safety and best dose of an experimental drug called CUE-102 in adults whose glioblastoma brain cancer has returned for the first time. CUE-102 is designed to activate the body's immune system to fight the tumor. The study will enroll about 18…

This early-stage trial is testing whether a new drug called RZ-001, when combined with an existing antiviral medication (valganciclovir), can help control glioblastoma, an aggressive brain cancer. The study will first determine safe doses and then see if the treatment shows signs…

This early-stage study is testing whether two experimental drugs, ABBV-637 and ABBV-155, are safe and tolerable when given alone or combined with another drug called ERAS-801. The trial involves 60 adults with recurrent glioblastoma, a fast-growing brain cancer, who have a specif…

This is the first study in people testing an experimental pill called ONC206 for adults with recurrent brain tumors that have few treatment options. The main goal is to find the highest safe dose and understand the side effects. Researchers will enroll about 102 patients to test …

This large, late-stage trial is testing whether adding the immunotherapy drug pembrolizumab to the standard treatment of Optune (a wearable device that uses electric fields) and chemotherapy helps people with newly diagnosed glioblastoma live longer. The study will involve 741 ad…

This study is testing a targeted drug called lorlatinib in children and young adults (ages 1-21) newly diagnosed with aggressive brain tumors (high-grade gliomas) that have specific genetic changes called ALK or ROS1 fusions. The main goals are to see if the drug can control the …

This study is testing if a drug called niraparib helps adults with a newly diagnosed, aggressive brain tumor (glioblastoma) live longer than the current standard drug, temozolomide. About 450 participants will be randomly assigned to receive one of these two drugs, taken daily al…

This study is testing two different drug combinations to see if they can help children and young adults with aggressive brain tumors live longer. The trial is for patients who have just finished radiation therapy. One group receives two drugs (ribociclib and everolimus), while an…

This program provides access to an experimental drug called AVM0703 for patients with various solid tumors and blood cancers. It is for people who may not have other treatment options. The drug aims to help the body's immune system fight cancer, and early reports show mostly mild…

This early-stage trial is testing whether two existing drugs—one for epilepsy and one previously studied for blood disorders—can help control aggressive brain cancer when added to standard treatment. Researchers will give 27-36 adults with newly diagnosed glioblastoma these drugs…

This study is testing a new drug called IVONESCIMAB for people whose glioblastoma brain cancer has returned after standard treatment. The first phase aims to find the safest and most effective dose. The second phase will see if that dose can help control the cancer's growth and e…

This study is testing whether adding an old antidepressant drug (trimipramine) to two existing cancer drugs can help control recurrent glioblastoma, a very aggressive brain tumor. It will involve 59 patients whose cancer has returned after standard treatment. The main goals are t…

This study is testing a new type of treatment called EBNK-001, which uses donated immune cells (Natural Killer cells) to fight cancer. It is for adults with advanced solid tumors that have grown or returned after standard treatments. The main goals are to find a safe dose and see…

This study is testing whether doctors can safely reduce the area of brain tissue exposed to radiation during glioblastoma treatment. Researchers want to see if using a smaller radiation target can decrease side effects like fatigue, memory problems, and headaches while maintainin…

This early-stage study is testing the safety of a two-part treatment for adults whose glioblastoma, a fast-growing brain cancer, has returned. First, doctors use a laser to heat and destroy the tumor. About a week later, patients take a chemotherapy pill called lomustine. The mai…

This early-stage study is testing an experimental drug called BDTX-1535 in people with aggressive brain tumors (high-grade glioma or glioblastoma) that have specific genetic changes in a protein called EGFR. The research aims to see if the drug reaches brain tumor tissue effectiv…

This early study is testing whether the drug troriluzole can help control recurrent glioblastoma, an aggressive brain cancer. About 27 adults whose cancer has returned will receive the drug either before and after standard tumor-removal surgery, or only after surgery, to see if i…

This study is testing whether placing tiny radiation seeds (GammaTile) directly into the brain during tumor removal surgery helps people with newly diagnosed glioblastoma live longer compared to standard treatment. The trial will enroll 766 adults who are medically fit for surger…

This study is testing a two-step treatment for brain tumors (gliomas) that have come back. First, doctors use a laser to heat and destroy tumor tissue. Then, patients receive a short, intense course of radiation therapy. The goal is to see if this combination can control the tumo…

This large international trial is testing several different treatments for glioblastoma (GBM), a fast-growing brain cancer. It aims to find which therapies work best for newly diagnosed patients and for those whose cancer has returned. The trial uses a smart, flexible design to q…

This study is testing whether starting a chemotherapy drug called temozolomide sooner after surgery and continuing it for a longer period helps adults with a newly diagnosed, aggressive brain cancer called glioblastoma live longer. It compares this more intensive approach to the …

This early-stage trial is testing a new drug called Peposertib, given alongside standard radiation and chemotherapy, for people newly diagnosed with a fast-growing type of brain tumor (glioblastoma). The main goals are to find the safest dose of Peposertib and see if it can get i…

This study is testing whether a special egg powder supplement can help people with glioblastoma, a serious brain cancer, live longer. About 300 newly diagnosed patients will take either the egg powder or a placebo daily during their standard chemotherapy and radiation treatments.…

This study is testing if a newer type of radiation (proton beams) causes fewer side effects than standard radiation (photon beams) for people with glioblastoma, a serious brain cancer. About 326 adults with this cancer will be randomly assigned to receive one of the two radiation…

This early-stage trial is testing a new oral drug called RSC-1255 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how well the drug is tolerated, both alone and combined with another medicati…

This study is testing several new drugs to see if they can help control glioblastoma, an aggressive brain cancer. It will compare these new drugs against standard chemotherapy (temozolomide) in about 460 adults who have recently had surgery. The goal is to see if matching specifi…

This early-stage study is testing a new type of personalized immune therapy called B7-H3-CAR T cells for children and young adults (up to age 21) with brain tumors that have come back or haven't responded to standard treatments. The therapy involves collecting a patient's own imm…

This global Phase 3 trial is testing whether adding a new targeted radiation therapy (TLX101-Tx) to standard chemotherapy (lomustine) works better than chemotherapy alone for adults whose aggressive brain cancer (glioblastoma) has returned for the first time. The new therapy aims…

This early study is testing if adding an experimental drug called azeliragon to the standard initial treatment for glioblastoma (a type of brain cancer) can change the immune environment inside the tumor. Researchers want to see if it reduces certain immune-suppressing cells and …

This study is testing a special microscope called the CONVIVO system. It is used during brain tumor surgery to help surgeons see the difference between healthy brain tissue and tumor tissue in real time. The images from the device are compared to standard lab tests from small tis…

This study is testing a new ultrasound fluid called SonoClear® to see if it helps surgeons get clearer pictures of brain tumors during surgery. Up to 15 adult patients with brain tumors in Germany will have their surgery imaged with both the new fluid and the standard fluid for c…

This study is testing a new noninvasive method called 'sonobiopsy' that uses focused ultrasound to help detect genetic markers from brain tumors in blood samples. Researchers want to see if this approach can provide detailed information about glioblastoma tumors without requiring…

This study is testing if the blood-thinning medication apixaban can safely prevent dangerous blood clots in people newly diagnosed with aggressive brain tumors (grade 4 glioma). It will involve about 40 adult patients who are starting radiation and chemotherapy. The main goal is …

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study is testing whether a short, personalized video can reduce anxiety for brain cancer patients and their caregivers during radiation treatment. The video uses the patient's own brain scan to explain their specific tumor and potential symptoms. Researchers want to see if t…

This study is testing whether a 6-week group program led by occupational therapists can help adults with primary brain tumors feel better and manage daily life while they are receiving cancer treatment. About 96 participants will be randomly assigned to either join the weekly gro…

This study aims to understand how aggressive brain tumors communicate with healthy brain cells using electrical signals. During brain surgery, researchers will safely record electrical activity from the tumor area and take small tissue samples. The goal is to learn if specific el…

This study aims to understand why some glioblastoma brain tumors respond better than others to TTFields treatment. Researchers will collect blood samples and existing tumor tissue from 80 newly diagnosed patients to look for biological markers that predict treatment success. The …

This study aims to find early signs from brain scans that can predict whether patients with recurrent glioblastoma (an aggressive brain cancer) will survive at least 6 months while taking the drug bevacizumab (Avastin). Researchers will scan patients' brains shortly after startin…

This study aims to understand what factors influence survival and quality of life for adults with glioblastoma, a serious brain cancer. Researchers will ask 200 participants to complete online surveys about their health history and lifestyle. Participants can also choose to provi…

This study is testing a new artificial intelligence (AI) tool designed to help match people with advanced cancer to suitable clinical trials. It will enroll up to 50,000 patients to see if using this AI system makes it easier for patients to find and join trials. The researchers …

This study is testing a tiny catheter placed during brain surgery to collect fluid from the tumor area. The goal is to find chemical markers in the fluid that could help doctors better understand, diagnose, and monitor brain tumors in the future. The procedure is done during a pa…

This study aims to see if a special fluorescent dye used during brain surgery can help create a blood test for glioblastoma, a very aggressive brain tumor. Researchers will collect blood and urine samples from about 30 patients before and after they receive the dye to measure its…

This early study aims to see how two new radioactive tracers travel through the body and gather in tumors. Researchers will give a single, tiny dose of one tracer to up to 32 patients with various solid tumors and then use PET/CT scans to track where it goes. The main goal is to …

This study aims to understand the biology of glioblastoma, a serious brain cancer, by analyzing MRI scans. Researchers will study 50 adults with this cancer who are scheduled for surgery. The goal is to find patterns in the scans that might predict which patients could benefit fr…

This study is testing three new types of MRI scans to see if they can help researchers understand the immune cells and environment around a brain tumor called glioblastoma. The goal is to find a less invasive way than surgery to learn why some of these tumors are resistant to tre…

This study aims to better understand glioblastoma, an aggressive brain cancer, by collecting and preserving tumor tissue during standard surgery. Researchers will take samples from different parts of the same tumor to study how they differ in structure and genetics. The goal is t…

This study aims to understand how often a protective fluid around the brain leaks after surgery to remove a brain tumor. Researchers will follow 200 adult patients to see who develops a leak, identify what factors make it more likely, and track how doctors manage it. The goal is …

This study aims to learn more about glioblastoma, an aggressive brain cancer, by using two types of specialized PET scans and a powerful MRI machine. Researchers will scan up to 15 adults with new or returning glioblastoma who are already scheduled for surgery. The goal is to see…