GLIOBLASTOMA

This study tests a new combination of drugs for children and young adults (ages 6–25) with brain cancers like medulloblastoma or glioblastoma that have come back or not responded to treatment. The goal is to find a safe dose of ibrutinib when added to an immunotherapy drug (indox…

This study tests a new way to treat glioblastoma, an aggressive brain cancer. Right after surgery to remove the tumor, doctors will give a single dose of targeted radiation inside the brain using a special balloon device. Then patients will receive standard chemotherapy and radia…

This study tests whether adding the immunotherapy drug pembrolizumab to standard treatment (tumor-treating fields plus chemotherapy) helps people with newly diagnosed glioblastoma live longer. About 741 adults will be randomly assigned to receive either the active drug or a place…

This study tests two drug combinations given after radiation for children and young adults with aggressive brain tumors (high-grade glioma or DIPG). One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The goal is to see if these combinations …

This large international study is testing several potential treatments at once for glioblastoma, an aggressive brain cancer. It includes both people newly diagnosed and those whose cancer has returned. The goal is to find which therapies work best by quickly adapting the trial ba…

This study tests a combination of three drugs (trimipramine, atezolizumab, and bevacizumab) in people whose glioblastoma brain tumor has returned after standard treatment. About 59 participants will receive the treatment for up to 2 years. The goal is to see if the combination ca…

This study tests a new drug, VRT106, in 42 adults with glioblastoma that has come back or worsened. The goal is to see if it is safe and can shrink tumors or help people live longer. Participants receive the drug by injection, and doctors monitor side effects and how well it work…

This early-phase study tests whether combining laser interstitial thermal therapy (LITT) with the chemotherapy drug lomustine is safe and feasible for adults whose glioblastoma has returned. About 20 participants will receive the laser treatment followed by chemotherapy within a …

This study tests the drug lorlatinib in children (ages 1 to 21) with a newly diagnosed high-grade glioma that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor and to check its safety when given with or after other …

This early-phase study tests a new drug called RSC-1255, alone or with hydroxychloroquine, in people with advanced solid tumors (like lung, colon, pancreatic cancer, or glioblastoma) that have stopped responding to standard treatments. The goal is to find a safe dose and see if t…

This early-stage study tests a radioactive drug called 131I-TLX101 given alongside standard treatments for people with newly diagnosed glioblastoma, an aggressive brain cancer. The main goal is to find a safe dose and check for side effects. About 12 adults who have had surgery f…

This study tests a combination of two drugs—Lutathera (a targeted radiation therapy) and olaparib (a PARP inhibitor)—in children and teens aged 3 to 18 with solid tumors that have come back or not responded to standard treatment. The goal is to find the safest dose and see if the…

This study tests combinations of experimental drugs (nogapendekin alfa inbakicept, PD-L1 t-haNK, bevacizumab) and tumor treatment fields in people whose glioblastoma has returned or worsened. The goal is to see if these treatments are safe and can help control the cancer. About 3…

This early-phase study tests whether giving the immunotherapy drug ipilimumab before standard surgery and chemoradiation is safe and helpful for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 16 adults will receive up to two doses of ipilimumab befor…

This study tests whether adding a cannabis-based mouth spray (Nabiximols) to standard chemotherapy can help people with a returning, aggressive brain tumor (glioblastoma) live longer. About 120 adults whose tumor has returned after initial treatment will be randomly assigned to r…

This early-phase trial tests two existing drugs, perampanel (used for epilepsy) and senicapoc (previously tested for blood disorders), alone and together, in adults with newly diagnosed glioblastoma. The goal is to see if these drugs are safe and can reach the brain to slow tumor…

This study tests if adding a special radiation tile (GammaTile) during brain tumor surgery can help people with a new glioblastoma diagnosis live longer. About 766 adults will be randomly assigned to standard treatment or standard treatment plus the tile. The goal is to see if th…

This program provides an experimental drug called AVM0703 to people with various cancers, including brain tumors, breast cancer, and leukemia. It is available in the US when a doctor requests it. So far, 37 patients have received the treatment, and side effects have been mostly m…

This early-phase study tests a new treatment for people with recurrent high-grade brain tumors (astrocytomas). A specially designed virus carrying two 'suicide' genes is injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the sa…

This early-phase study tests whether adding the drug azeliragon to standard chemoradiotherapy can help the immune system fight glioblastoma, an aggressive brain cancer. About 12 adults with newly diagnosed tumors will receive either standard treatment or standard treatment plus a…

This study tests a drug called ivonescimab in people whose glioblastoma (a type of brain cancer) has come back after standard treatment. The first part finds the safest dose, and the second part checks if that dose can control the tumor. About 45 adults with recurrent glioblastom…

This study tests several new drugs, alone or with standard chemotherapy, for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 460 adults who have had surgery but not yet radiation or other treatments will take part. The goal is to see if these experime…

This study tests an experimental drug called BDTX-1535 in people with aggressive brain tumors (high-grade glioma or glioblastoma) that have a specific change in the EGFR gene. The drug aims to block a growth signal that these tumors rely on. The study will first measure how much …

This study tests a combination of three drugs (pembrolizumab, olaparib, and temozolomide) in people whose glioblastoma brain tumor has come back after initial treatment. The goal is to see if the combination can shrink the tumor or slow its growth. About 78 adults will take part,…

This study tests if methimazole, a drug used for thyroid conditions, can help people with progressive glioblastoma (a serious brain cancer). Researchers will give different doses to find a safe and effective level. The goal is to see if the drug can slow tumor growth and improve …

This study tests whether adding silibinin (a milk thistle extract) to standard chemoradiation and maintenance therapy can delay tumor growth in people with a specific type of newly diagnosed glioblastoma. About 110 participants will receive either silibinin or a placebo alongside…

This early-stage trial tests a new treatment called E-SYNC CAR T cells for people with a specific form of glioblastoma, an aggressive brain cancer. The therapy involves taking a patient's own immune cells, modifying them in a lab to better recognize and attack the tumor, and infu…

This early-stage trial tests an oral drug called ONC206 in adults with brain tumors that have come back. The main goal is to find the safest dose and understand side effects. About 102 participants will receive the drug weekly or multiple days per week.

This study follows children who previously took dabrafenib and/or trametinib for certain brain tumors. It aims to see how safe these drugs are over the long term by tracking side effects and monitoring growth. About 163 children are enrolled, and the study is no longer recruiting…

This study tests a new drug, TLX101-Tx, which delivers radiation directly to glioblastoma cells, combined with standard chemotherapy (lomustine) in 50 adults whose brain cancer has returned after initial treatment. The goal is to see if the combination helps control the tumor bet…

This early-stage trial tests a new drug called Peposertib, combined with radiation and chemotherapy, for people with a fast-growing brain cancer (glioblastoma) that has a specific genetic marker (MGMT unmethylated). The goal is to find the best dose and see if the drug can reach …

This study tests a more intense treatment for a fast-growing type of brain cancer called IDH wildtype glioma. It combines higher doses of radiation with the chemotherapy drug temozolomide to try to stop the tumor from growing longer. The trial will enroll 40 adults with this spec…

This early-stage trial tests a new treatment for children and young adults (up to age 21) with certain brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a p…

This study tests whether adding focused ultrasound (NaviFUS) to the standard drug Avastin can help people with recurrent glioblastoma, a serious brain cancer. About 32 adults whose tumor has come back after prior treatment will be randomly assigned to get Avastin alone or Avastin…

This program provides ulixertinib, an experimental drug, to adults with advanced solid tumors that have specific genetic changes (MAPK pathway mutations) and who have run out of standard treatments. The goal is to control the cancer, not cure it. Participants may take ulixertinib…

This study tests a new treatment called EBNK-001, which uses donor natural killer (NK) cells to fight advanced solid tumors. About 83 adults with cancers like lung, breast, or colorectal cancer that have not responded to standard treatments will receive the NK cells along with ch…

This early-stage trial tests a new drug called RZ-001 combined with valganciclovir in people with glioblastoma, an aggressive brain cancer. The study aims to find the safest dose and see if the treatment can shrink tumors or help people live longer. About 43 adults whose tumors h…

This early-phase study tests a new treatment called CARv3-TEAM-E T cells for people with glioblastoma, a fast-growing brain cancer that has come back. The therapy uses a patient's own immune cells, modified in a lab to better recognize and attack the tumor. The main goals are to …

This study tests a different way of giving the chemotherapy drug temozolomide to people aged 65 and older with a type of brain cancer called glioblastoma that has a marker making standard treatment less effective. The goal is to see if this daily dosing can help slow the cancer a…

This early-phase study tests a drug called WSD0628 combined with radiation therapy for people whose high-grade glioma (a type of brain tumor) has come back after prior treatment. The main goal is to find the safest dose and check for side effects. About 94 adults with recurrent g…

This study tests a treatment using donor immune cells (CAR-NK cells) designed to attack cancer. The specific target on the cancer cells is chosen based on a biopsy of the tumor or a blood test. The goal is to see if this approach is safe and can shrink or control advanced solid t…

This study tests a new treatment for aggressive brain tumors (glioblastoma) that uses a radioactive substance attached to a targeting molecule to deliver radiation directly to cancer cells. It is for adults aged 18-80 who have completed standard therapy but need extra treatment. …

This early-phase study tests a new treatment for adults with glioblastoma or high-grade glioma that has come back after standard therapy. The treatment uses specially engineered natural killer (NK) cells designed to target two different markers on tumor cells at once, which may h…

This study tests a new gene therapy (HSV-tk) plus valacyclovir, given alongside standard radiation and chemotherapy, for people newly diagnosed with aggressive brain tumors (glioblastoma or anaplastic astrocytoma). The goal is to see if this combination can help patients live lon…

This study tests whether a daily egg powder enriched with a natural protein called antisecretory factor can help people with newly diagnosed glioblastoma live longer. About 300 participants will receive either the active egg powder or a placebo alongside standard chemotherapy and…

This early-phase study tests a new two-drug combination for adults whose high-grade glioma (a fast-growing brain tumor) has returned after standard treatments. The drugs are temozolomide (given in low, frequent doses) and abexinostat (an experimental pill). The main goal is to fi…

This study tests a treatment plan for people whose brain tumors (gliomas) have come back after standard therapy. The approach uses laser heat to destroy tumor tissue, followed by a short course of focused radiation. The goal is to control the tumor and see if the combination is s…

This study tests a drug called PLX038 in adults with brain or spinal cord tumors, especially those with changes in the MYC or MYCN genes. The goal is to see if the drug can shrink tumors or stop them from growing. Participants receive the drug through an IV every 3 weeks for up t…

This early-stage study tests whether using sound waves (NaviFUS system) can help the drug bevacizumab work better for people with recurrent glioblastoma, an aggressive brain cancer. About 10 adults whose cancer has returned after standard treatments will receive the drug plus sou…

This study tests whether giving radiation in a smaller, more focused area can reduce side effects and improve quality of life for people with glioblastoma, an aggressive brain cancer. About 347 participants will receive standard chemoradiotherapy, but half will get a smaller radi…

This study tests a new drug that delivers radiation directly to cancer cells with a specific marker (GRPR). It is for adults with advanced cancers like prostate, breast, lung, or colon cancer that have come back or spread. The main goal is to find a safe dose and check for side e…

This study tests a new treatment for glioblastoma, an aggressive brain cancer. It combines an investigational drug (5-ALA) with a non-invasive ultrasound device to target tumor cells. About 103 patients who have completed standard therapy will be randomly assigned to receive eith…

This early-phase study tests an experimental oral drug called GLIX1 in 30 adults whose aggressive brain tumor (high-grade glioma) has come back or worsened after standard treatments. The main goals are to find a safe dose and check for any signs that the drug can control the dise…

This phase 3 trial tests whether a device called SonoCloud-9 can temporarily open the blood-brain barrier, allowing more chemotherapy (carboplatin) to reach brain tumors in people with recurrent glioblastoma. About 560 participants will be randomly assigned to receive either carb…

This study tests an experimental drug called ONC206, alone or with radiation, in children and young adults with a rare and aggressive brain tumor called diffuse midline glioma (DMG) or other recurring brain cancers. The goal is to find the best dose and see if it is safe. ONC206 …

This early-phase study tests an experimental drug called CUE-102 in 18 adults whose glioblastoma (a type of brain cancer) has returned after initial treatment. The main goal is to check the drug's safety and find the best dose. Participants must have a specific genetic marker (HL…

This study tests a new drug, niraparib, against the standard treatment temozolomide in adults with a newly diagnosed, hard-to-treat type of glioblastoma (a brain cancer). About 450 participants will be randomly assigned to one of the two drugs, taken daily during radiation. The m…

This study tests whether adding the drug ruxolitinib to standard treatment (radiation and temozolomide) helps people with newly diagnosed glioblastoma live longer. About 190 adults will be randomly assigned to receive either the standard treatment alone or standard treatment plus…

This early-stage study tests whether two experimental drugs, ABBV-637 and ABBV-155, are safe when given alone or with another drug called ERAS-801 for people whose glioblastoma has come back. About 60 adults with a specific type of brain tumor (EGFR gene amplified) will take part…

This study tests whether giving a higher dose of radiation along with a drug called bevacizumab can help people with a fast-growing brain tumor called glioblastoma live longer. The drug is meant to protect healthy tissue from the extra radiation. About 146 adults aged 18 to 70 wi…

This study tests a special microscope called CONVIVO that lets surgeons see brain tissue up close during surgery. The goal is to help them tell the difference between normal brain and tumor tissue right away. About 30 adults with different types of brain tumors will take part. Th…

This study tests sonobiopsy, a noninvasive technique that uses focused ultrasound to release tumor DNA into the bloodstream for easier detection. About 40 adults with suspected glioblastoma will undergo the procedure before standard surgery. The goal is to see if this method can …

This study tests whether the blood thinner apixaban can safely prevent blood clots in people with newly diagnosed grade 4 glioma (a type of brain cancer). About 40 participants will take apixaban while receiving standard radiation and chemotherapy. The main goal is to check for b…

This study tests whether a custom video that shows symptoms specific to a patient's brain tumor can lower anxiety during radiation treatment. About 117 patients with newly diagnosed gliomas and their caregivers will take part. The video is made from the patient's own MRI scan and…

This study tests whether proton beam radiation causes fewer side effects than standard photon radiation in people with glioblastoma, a fast-growing brain tumor. About 326 adults who need radiation after surgery or biopsy will be randomly assigned to one of the two methods. The ma…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if patients prefer home care and if it is safe. Participants will receive their usual cancer drugs either at home or in the clini…

This study tests a 6-week occupational therapy group program for adults with primary brain tumors who are on active treatment. The program covers fatigue management, cognitive strategies, relaxation, and peer support. Researchers want to see if it improves quality of life and dai…

This study is testing whether a blood or urine test can detect signals from brain tumors, especially glioblastoma. Researchers will use a special dye (5-ALA) that makes tumor cells glow during surgery to help link what's seen in the blood to the actual tumor. The goal is to devel…

This pilot study will use two types of PET scans and a powerful 7Tesla MRI to create detailed metabolic profiles of glioblastoma, both in newly diagnosed and recurrent tumors. Researchers will compare the scan results with lab tests on tumor tissue to better understand how these …

This study is for children, teens, and young adults (ages 1 to 39) newly diagnosed with a high-grade glioma, a serious type of brain tumor. Researchers will analyze the tumor's genetic makeup to see if it matches a specific treatment plan in a future study. The goal is to learn m…

This study aims to find early signs in the brain that can predict if a glioblastoma patient will survive at least 6 months after starting bevacizumab. Researchers will use special MRI scans to measure certain chemicals in the tumor. The goal is to help doctors decide which patien…

This study watches 200 adults having brain tumor surgery to see how often cerebrospinal fluid leaks occur, what makes them more likely, and how doctors treat them. The goal is to find ways to reduce leaks and help patients heal better.

This study collects samples of glioblastoma (a type of brain tumor) and blood from 120 adults during standard surgery. Researchers will examine tissue from different parts of the same tumor to see how they differ. The goal is to learn more about the tumor's structure and behavior…

This study compares two common methods of closing the skin after brain tumor surgery: running stitches (absorbable) and individual stitches (non-absorbable). The goal is to see which method leads to fewer wound problems like infection or fluid leaks. About 382 adults having plann…

This study looks at how much of the drug T-DXd gets into brain tumors after being injected into the body. It includes 30 adults with brain cancer that has the HER2 protein. Researchers will measure drug levels in the tumor during surgery to see if it could be a useful treatment.

This study will collect blood and tumor samples from 80 people with newly diagnosed glioblastoma to look for biological markers that predict how the tumor responds to TTFields (electric field therapy). Participants will receive standard treatment plus TTFields, and samples will b…

This study is testing whether an artificial intelligence (AI) tool can help match people with advanced cancer to the right clinical trials. Researchers will enroll up to 50,000 participants to see if the AI improves trial enrollment rates and patient outcomes. The goal is to make…

This study looks at whether having surgery to remove a returning glioblastoma brain tumor helps people live longer and feel better compared to skipping surgery. About 120 adults whose cancer came back after standard treatment will be randomly assigned to either have surgery plus …

This study is testing whether a small device called a microdialysis catheter can safely collect fluid samples from brain tumors during surgery. The goal is to measure biomarkers—natural substances that show how the tumor behaves. Researchers hope this information will lead to bet…

This study looks at MRI scans and a protein called decorin in 50 patients with glioblastoma, a serious brain cancer. The goal is to find out which patients might benefit from a drug called bevacizumab. Researchers will compare imaging and tissue samples to better understand tumor…

This study tests whether using a special PET scan (FDOPA-PET) to guide radiation therapy can help people with recurrent glioblastoma, an aggressive brain cancer. About 54 adults whose tumor has returned after prior radiation will receive targeted radiation based on the PET images…

This study is for people newly diagnosed with a type of aggressive brain cancer called glioblastoma. Researchers will take a sample of the tumor during surgery and grow the cells in a lab to test which drugs kill them best. Based on those results, participants may receive a perso…

This study tests three advanced MRI methods to look at the cells and proteins around glioblastoma brain tumors without needing surgery. Researchers want to understand why some tumors are harder to treat. About 15 adults with suspected glioblastoma will have these special scans be…

This study is testing whether a new radioactive imaging agent can safely and clearly show tumors in people with many types of solid cancers. About 32 adults will receive a single injection of the agent and then have PET/CT scans to see where it goes in the body. The goal is to le…

This early-phase study tests if recording electrical activity in and around high-grade glioma tumors during surgery is safe and feasible. Researchers will take small tissue samples from areas with unusual activity and track tumor progression on follow-up MRI scans. The goal is to…

This study tests a special egg yolk powder called Salovum® in 10 adults with suspected glioblastoma, a serious brain cancer. Researchers want to see if the powder can reduce pressure inside the tumor and change inflammation levels. Participants take the powder after a biopsy whil…

This study tests the drug troriluzole in people with recurrent glioblastoma, a type of brain cancer. Participants take the drug before surgery to see how it affects brain activity and glutamate levels in the tumor. The goal is to learn more about the drug's effects, not to treat …

This observational study aims to identify factors that influence survival and quality of life in adults with glioblastoma, a severe brain cancer. Researchers will examine genetic, immune, occupational, and medical history data from 200 participants. Participants complete an onlin…