Laser and radiation combo takes on recurrent brain tumors

NCT ID NCT04181684

Recruiting now Disease control Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study is testing a two-step treatment for people whose gliomas (a type of brain tumor) have come back after standard therapy. First, doctors use a laser guided by MRI to destroy as much tumor as possible. Then, they give a short course of focused radiation. The main goal is to see if this combination is safe and can help control the tumor's growth. About 32 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Laser interstitial thermal therapy (LITT) and hypofractionated radiation therapy
What this could lead to: If successful, this combination could offer a new treatment option to control recurrent gliomas and extend time without tumor progression.
What could go wrong: This is a small, early pilot study with only 32 participants. It focuses on safety first, so it's too soon to know if it will improve survival. There are risks from both the laser procedure and radiation.

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm glioblastoma glioma neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN TUMOR GLIOBLASTOMA GLIOMA NEOPLASMS

Contacts and locations

Locations

Baltimore Washington Medical Center
RECRUITING

Glen Burnie, Maryland, 21061, United States
Central Maryland Radiation Oncology
RECRUITING

Columbia, Maryland, 21044, United States
UCH Kaufman Cancer Center
RECRUITING

Bel Air, Maryland, 21014, United States
University of Maryland Greenebaum Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States

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