NEOPLASMS

This early-stage study is testing a new type of personalized cell therapy for people with advanced solid tumors, including mesothelioma, that have come back or spread after standard treatments. Doctors collect a patient's own immune cells, genetically modify them in a lab to bett…

This study is testing a new smartphone app designed to help people with cancer take their oral medication correctly. The app tracks pill-taking, monitors symptoms, and connects patients with support for side effects and costs. Researchers are enrolling 35 English- or Spanish-spea…

This study is testing a new drug called Pocenbrodib to see if it is safe and can help control advanced prostate cancer that has spread and is no longer responding to standard hormone treatments. Researchers will give Pocenbrodib alone or combined with other cancer drugs to about …

This early-stage study is testing the safety and initial effectiveness of a new cell therapy called IL-5 CAR-T for adults with a rare and aggressive blood cancer called eosinophilic leukemia that has not responded to standard treatments. Doctors will collect a patient's own immun…

This study is testing whether giving two immunotherapy drugs before surgery can shrink bladder tumors enough to avoid removing the bladder entirely. The trial will enroll 90 adults with muscle-invasive bladder cancer who are not receiving standard chemotherapy. Researchers will c…

This is an early-stage study to test the safety and find the right dose of a new personalized cell therapy called JV-394. It is for adults with specific types of T or NK cell lymphomas that have come back or not responded to at least one prior treatment. The therapy involves coll…

This study is testing whether a coordinated care program helps older adults complete their planned digestive cancer chemotherapy. It will enroll 144 participants aged 75 and older who are starting treatment. The goal is to see if early support from a team of specialists helps pat…

This study offers a fertility preservation option for young female cancer patients. It involves surgically removing and freezing a piece of ovarian tissue before cancer treatments like chemotherapy, which can damage fertility. The frozen tissue can later be transplanted back to p…

This study is testing the safety of an experimental virus therapy called G207 for children and young adults with recurrent or hard-to-treat brain tumors in the cerebellum. The virus is designed to infect and kill cancer cells while sparing healthy ones. Researchers will also test…

This trial is a flexible 'master protocol' designed to test multiple new cancer drugs for children and young adults more efficiently. It will enroll about 105 participants with various cancers. As new promising drugs emerge, they can be added to the trial for testing, allowing re…

This is the first study in people to test a new drug called JNJ-88549968 for blood cancers with a specific genetic change (CALR mutation). The main goals are to find a safe dose and understand how the body handles the drug. The drug works by guiding a patient's own immune cells t…

This study is testing whether adding a new drug called SLC-3010 to an existing cancer drug (axitinib) works better than using axitinib alone. It is for adults with advanced kidney cancer that has worsened after their first treatment. The main goal is to see if the combination hel…

This study is testing whether a combination of two existing cancer drugs, nilotinib and paclitaxel, can help control rare cancers that have stopped responding to standard treatments. It is for adults with specific rare, advanced solid tumors, including certain ovarian cancers, an…

This study is observing how well the drug vorolanib works and how safe it is for patients with advanced kidney cancer that has spread or cannot be removed by surgery. It involves 39 adults who are receiving vorolanib as their second treatment option. Researchers will track how lo…

This early-stage study is testing a new oral drug called GSK5460025, given alone or with other cancer treatments, in adults with advanced solid tumors that have specific genetic characteristics (dMMR or MSI-H). The main goals are to find a safe dose, see how the body processes th…

This early-stage study is testing a new experimental drug called GSK5764227 in adults with advanced solid tumors that have spread or cannot be surgically removed. Researchers want to find the safest dose and see how the drug behaves in the body when given alone or combined with o…

This early-stage study is testing a new experimental drug called JNJ-87890387 in people with advanced solid tumors that have spread or cannot be surgically removed. The main goals are to find a safe dose and understand how the body handles the drug. The trial is enrolling 200 adu…

This is an early-stage study to find a safe dose of a new drug called RO7673396 for people with advanced solid tumors that have a specific genetic change called a RAS mutation. The study will first test increasing doses to see what is safe, then test that dose to see if it helps …

This is an early-stage study to test the safety and determine the best dose of a new oral medication called ABSK021 in people with advanced solid tumors that have stopped responding to standard treatments. The trial will enroll about 276 participants, including those with a rare …

This early-stage study is testing a new treatment called JNJ-87704916, which is a modified virus designed to infect and kill cancer cells. It will be injected directly into tumors of patients with advanced solid tumors who have run out of standard treatment options. The main goal…

This early-stage trial is testing a new oral drug called Aza-TdC in adults with advanced solid tumors that have worsened after standard treatments. The main goal is to find a safe dose and see how well the body handles the drug. Researchers hope the medication can turn back on ce…

This early-stage study is testing the safety and finding the right dose of a new oral drug called nenocorilant when given alongside an existing immunotherapy drug (nivolumab). It will involve about 50 adults with advanced solid tumors that have stopped responding to standard trea…

This study is testing a two-step treatment for brain tumors (gliomas) that have come back. First, doctors use a laser to heat and destroy tumor tissue. Then, patients receive a short, intense course of radiation therapy. The goal is to see if this combination can control the tumo…

This study is testing whether two drugs, elacestrant and abemaciclib, work together to control breast cancer that has spread to the brain. It will involve about 73 adults whose cancer is fueled by estrogen and has spread to the brain. The first part finds the safest dose, and the…

This early-stage trial is testing a new cancer medicine called GSK5764227, which works like a targeted delivery system to bring a toxin directly to cancer cells while trying to avoid healthy ones. The study will combine this experimental drug with standard cancer treatments in 84…

This study aims to find the best screening methods to detect precancerous anal lesions in people at high risk for anal cancer. Researchers will test several screening markers and analyze biological samples from 500 participants with weakened immune systems or a history of other H…

This study is observing how well a robotic system works in real hospitals to help doctors locate and take samples from suspicious spots in the lungs. It will follow 3,000 patients who are already scheduled to have this robotic-assisted biopsy procedure. The main goal is to see ho…

This study is testing a new type of PET/CT scan that uses a special tracer called [18F]RCCB6. The goal is to see if this scan can more accurately detect and diagnose kidney cancer, especially a common type called clear cell renal cell carcinoma. Researchers will enroll 300 partic…

This study is testing a new, non-invasive pad device to see if it can collect enough cells from the uterus to help detect cancer or pre-cancer. Participants will wear the pad for a few hours and then answer questions about how comfortable and easy it was compared to standard test…

This study is testing if adding a special type of mammogram that uses contrast dye every two years helps find returning breast cancer more effectively in women with a personal history of the disease. It will involve 1,500 women who get their regular annual mammogram plus this ext…

This study offers ovarian tissue freezing to young female cancer patients (ages 0-35) to preserve their ability to have children later in life. The procedure is designed for patients who need to start cancer treatments like chemotherapy or radiation immediately, as it does not re…

This is a small pilot study to see if a future larger trial is possible. It will test two different schedules of a gentle self-massage technique called manual lymphatic drainage. The goal is to see if this massage can reduce swelling in the face and neck (lymphedema) that sometim…

This study is testing a new drug, LY3537021, to see if it works better than a placebo at preventing nausea and vomiting caused by certain strong chemotherapy drugs. It will involve about 204 adults with cancer who are new to chemotherapy. Participants will be randomly assigned to…

This study is testing whether a new program led by nurses can help cancer patients stay physically active while receiving outpatient treatment like chemotherapy. The program, called OnkoMoveNurse, provides safe exercises and support. Researchers will enroll about 50 patients to s…

This study is testing whether online health education workshops are a practical way to support French adolescents and young adults with cancer. Researchers will offer three digital workshops to 48 participants to help them manage the challenges of their diagnosis and treatment. T…

This study aims to monitor the long-term safety and effectiveness of gene-modified T-cell therapy in people who have already received this treatment for cancer in a previous clinical trial. It will follow over 1,500 participants, including children and adults, for up to 15 years …

This study is creating and testing an online learning tool designed to help people with cancer improve their skills at finding and understanding reliable health information on the internet. Researchers will enroll 660 cancer patients and randomly assign them to either use the int…

This study aims to find new markers in blood that could help doctors monitor how well cancer treatments are working. Researchers will collect blood samples from 2,000 cancer patients before, during, and after treatment to identify proteins that signal treatment response or diseas…

This study is testing a new imaging agent called [18F]LY4214835 to see if it is safe and to measure how much radiation it delivers to different organs. It involves both healthy volunteers and people with cancer who will receive a single injection and be followed for about 35 days…

This large international study is collecting information on a new, more precise type of radiation therapy that uses real-time MRI scans to guide treatment. It aims to see if this advanced technology helps people with many types of cancer live longer, better control their tumors, …

This study aims to create a better tool to predict which cancer patients might develop heart problems from certain powerful chemotherapy drugs. Researchers will use a computer program (machine learning) to analyze data from 600 patients receiving treatment. The goal is to identif…

This study collects blood, bone marrow, urine, and tissue samples from people with cancer, blood disorders, or their compatible family members. The samples are used for laboratory research to better understand these diseases, evaluate current treatments, and identify potential ne…

This study collects tissue and fluid samples from adults and children with cancer. The goal is to gather these samples for research to help scientists better understand cancer and develop new tests and models for future treatments. Samples are collected during procedures patients…

This study aims to understand why a small percentage of cancer patients experience unexpectedly severe side effects from radiation therapy. Researchers will compare blood samples from 40 patients who had severe reactions with those who did not. The goal is to find immune system m…

This study aims to better understand Li-Fraumeni syndrome (LFS), a rare genetic condition that greatly increases a person's risk of developing many types of cancer. Researchers will follow 5,000 individuals and families with LFS over many years to learn about the types of cancers…

This study aims to monitor the long-term safety of people who have already received a specific type of cell therapy for cancer. It will follow up to 250 participants for 15 years after their last treatment to check for any delayed side effects. This is an observational study, mea…

This study is creating a digital program designed to help East Asian immigrants with cancer talk with their families about their future care wishes. Researchers will first interview religious leaders to understand cultural barriers, then develop and test the program with 27 patie…

This study aims to collect and analyze information from 40,000 cancer patients receiving different types of radiation therapy. Researchers will track treatment results and side effects to understand what works best. The goal is to use this information to improve future patient ca…