NEOPLASMS

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors, including mesothelioma, that have returned or spread after standard therapy. The treatment involves collecting a patient's own immune cells, modifying them in a lab to better re…

This early-stage study tests a new treatment called IL-5 CAR-T cell therapy for people with a rare and hard-to-treat blood cancer called eosinophilic leukemia. The therapy uses a patient's own immune cells, modified in a lab to target and attack cancer cells. The study aims to se…

This study tests two drugs, elacestrant and abemaciclib, in people whose breast cancer has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. About 73 adults with ER-positive, HER2-negative breast cancer will take part. The study is cur…

This early-phase trial tests a new oral drug, Aza-TdC, in adults with advanced solid tumors that have not responded to standard treatments. The drug aims to 'turn back on' genes that may slow tumor growth. The main goals are to check the drug's safety and find the best dose.

This early-stage study tests a virus (JNJ-87704916) that is injected directly into tumors to kill cancer cells. It is being tested alone and with another drug (cetrelimab) in people with advanced solid tumors who have run out of standard treatments. The main goals are to check sa…

This early-stage study tests a new drug called AST-201 in about 70 adults with advanced solid tumors that have a specific protein (GPC3). The main goal is to check the drug's safety and find the right dose. Researchers will also look at how the drug moves through the body and whe…

This study tests a new medicine, GSK5764227, that delivers a toxin directly to cancer cells to destroy them while leaving healthy cells alone. It is given together with standard treatments to people with advanced solid tumors (colorectal or prostate cancer). The main goals are to…

This early-phase study tests an experimental drug called JNJ-87890387 in people with advanced solid tumors (kidney, ovarian, uterine, colorectal, or lung cancer) that have spread or cannot be removed. The main goals are to find a safe dose and check for side effects. About 200 pa…

This study creates a common framework to test multiple new cancer drugs in children and young adults more efficiently. About 105 participants with measurable or evaluable tumors will join, and their continued participation depends on how long the treatment helps. The goal is to s…

This early-stage study tests an experimental drug called JNJ-88549968 in people with certain blood cancers (myelofibrosis or essential thrombocythemia) that have a specific CALR gene mutation. The drug is a bispecific antibody designed to redirect the body's immune T-cells to att…

This early-stage study tests a new drug (RO7673396) in people with advanced solid tumors that have RAS mutations and haven't responded to standard treatments. The study has two parts: first, finding a safe dose, and second, checking if the drug shrinks tumors when given alone or …

This early-stage study tests an experimental pill called ABSK021 in people with advanced solid tumors (including a rare joint tumor called TGCT) who have run out of standard options. The main goal is to check safety and find the right dose, while also seeing if the drug can shrin…

This study tests an experimental oral drug (GSK5460025) in adults with advanced solid tumors that have specific genetic features (dMMR or MSI-H), which often make them harder to treat. The drug is given alone or with other cancer medicines to see if it can shrink tumors and how s…

This study is testing an experimental chemotherapy drug, JNJ-1761981 ER, that is injected directly into tumors. The goal is to find a safe and effective dose for people with advanced solid tumors who have not responded to other treatments. About 66 participants will take part in …

This study tests whether giving two immunotherapy drugs (nivolumab with or without relatlimab) before surgery can eliminate bladder cancer completely, allowing some patients to avoid bladder removal. About 90 adults with stage II-IIIa bladder cancer will receive the drugs and the…

This study tests whether adding focused ultrasound (NaviFUS) to the standard drug Avastin can help people with recurrent glioblastoma, a serious brain cancer. About 32 adults whose tumor has come back after prior treatment will be randomly assigned to get Avastin alone or Avastin…

This early-stage study tests a new drug, GSK5764227, alone or with other cancer medicines, in adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors. About 59…

This early-stage study tests a new drug called GSK5533524 in about 97 adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors or slow cancer growth. Researchers will also m…

This early-phase study tests a new treatment called JV-394 for people with T/NK cell lymphoma that has come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified to attack cancer cells. The main goals are to find the safest dose an…

This study looks at a way to help young women and girls with cancer keep their ability to have children. Doctors will freeze a piece of their ovary before cancer treatment starts. Later, after treatment, the tissue can be put back into the body. The goal is to see if this method …

This study looks at how well the drug vorolanib works for people with advanced kidney cancer that has spread or cannot be removed by surgery. It is for patients who need a second treatment after the first one stopped working. Researchers will track how long patients live without …

This study tests a new drug called nenocorilant combined with an immunotherapy (nivolumab) in people with advanced solid tumors that have not responded to standard treatments. The goal is to find the best dose and see if the combination can shrink tumors or slow their growth. Abo…

This study tests whether adding the experimental drug SLC-3010 to the standard drug axitinib works better than axitinib alone for people with advanced clear cell kidney cancer that has worsened after first treatment. About 78 adults will be randomly assigned to one of the two gro…

This study tests a new drug called pocenbrodib, either by itself or combined with other treatments, in people with a type of advanced prostate cancer that no longer responds to hormone therapy. The goal is to find the safest dose and see if it helps shrink tumors or lower PSA lev…

This study tests a treatment plan for people whose brain tumors (gliomas) have come back after standard therapy. The approach uses laser heat to destroy tumor tissue, followed by a short course of focused radiation. The goal is to control the tumor and see if the combination is s…

This early-stage study tests whether using sound waves (NaviFUS system) can help the drug bevacizumab work better for people with recurrent glioblastoma, an aggressive brain cancer. About 10 adults whose cancer has returned after standard treatments will receive the drug plus sou…

This study offers female cancer patients a way to preserve their fertility. Doctors freeze a piece of ovarian tissue before cancer treatment starts, then transplant it back after treatment ends. The goal is to help these patients become pregnant naturally. The study tracks surgic…

This study tests two drugs, nilotinib and paclitaxel, together in people with rare advanced cancers that have not responded to standard treatments. The goal is to see if the combination can shrink or stop tumor growth. About 82 adults with specific rare cancers like certain ovari…

This early-stage trial tests a specially engineered virus, G207, in children and young adults whose cerebellar brain tumors have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a single low dose of radiation is given to help t…

This study tests a new injection called [18F]LY4214835 to see if it is safe and can help detect cancer in the body. About 41 healthy volunteers and people with cancer will receive the injection and be monitored for side effects and how the substance spreads. The goal is to improv…

This study looks at whether adding a special type of mammogram (contrast-enhanced mammography, or CEM) every two years to the standard yearly 3D mammogram can find breast cancer earlier in women who have already had breast cancer. About 1,500 women aged 30-79 who are at least one…

This study aims to see if a new imaging agent called [18F]RCCB6 can improve the detection of kidney cancer, especially the most common type (clear cell renal cell carcinoma). Researchers will enroll 300 adults with confirmed or suspected kidney cancer to measure how well the trac…

This study aims to see how well a robotic system works for finding and taking samples from suspicious spots in the lungs. It will observe 3,000 adults who are already scheduled to have this procedure as part of their regular care. The main goal is to measure how often the biopsy …

This study tests a mobile health app designed to help cancer patients remember to take their oral anticancer medications and report any side effects. Researchers will enroll 35 English- or Spanish-speaking adults with cancer who are starting or recently started a new oral therapy…

This study tests a nurse-led program to help cancer patients be more physically active while receiving treatment in an outpatient clinic. The goal is to see if the program is practical and can improve patients' well-being and mood. About 50 adults with cancer will take part, and …

This study tests an experimental drug called LY3537021 to see if it can better control nausea and vomiting caused by chemotherapy. About 204 adults with cancer who are starting chemotherapy will receive either the drug or a placebo. The goal is to reduce the need for rescue medic…

This study looks at whether a special type of massage, called manual lymph drainage, can help reduce swelling in the face and neck caused by radiation therapy for head and neck cancer. Researchers will test if it's possible to run a larger study by enrolling 40 people who complet…

This study looks at whether an early, coordinated care program can help people aged 75 and older with digestive cancer finish their planned chemotherapy or targeted therapy. About 144 participants will be randomly assigned to either the special program or standard care. The main …

This study collects tumor samples and medical information from 1,500 people with pancreatic cancer. The goal is to build a large biobank that researchers can use to better understand the disease and develop new treatments. Participants do not receive any experimental therapy; the…

This study aims to find proteins and other markers in the blood that can help doctors diagnose cancer, choose the right treatments, and monitor how well a patient responds to therapy. Researchers will analyze blood samples from 2,000 adults who either have cancer or are suspected…

This study looks at how immunotherapy for advanced cancer changes a person's physical fitness and quality of life. About 67 adults will do fitness tests and fill out questionnaires before starting treatment and again 12 weeks later. Researchers will also track their health for up…

This study is creating a digital program to help East Asian immigrants who have cancer start conversations with their family about future medical care. Researchers will test how easy and acceptable the tool is for 84 participants, including patients and religious leaders. The goa…

This study follows children and adults who have already received gene-modified T cells in a previous trial. It does not give any new treatment but checks for long-term side effects, how long the modified cells last, and overall survival. The goal is to understand the lasting safe…

This study gathers information from 40,000 people receiving radiation therapy for cancer. Researchers will analyze the data to understand what works best and how to reduce side effects. The goal is to improve future treatment and care for patients.

This study collects tissue and fluid samples (like blood, urine, and tumor biopsies) from up to 5,000 children and adults with cancer. The samples are used for research to better understand cancer and develop new tests or treatments. Participants do not receive any experimental t…

This study follows up to 250 people who have already received ADP adoptive cell therapy for cancer. The goal is to track any delayed side effects or serious health issues for up to 15 years after their last treatment. Participants do not receive new therapy but provide blood samp…

This study looks at new ways to screen for anal precancer in people at high risk, such as those with weakened immune systems. Researchers will test different screening methods to see which ones work best. They will also study DNA and immune factors linked to the condition. The go…

This study is creating and testing an interactive online learning tool to help people with cancer improve their ability to find and understand health information on the internet. About 660 adults with any type of cancer will take part. Some will use the online tool, some will get…

This study aims to create a computer-based tool that can predict which cancer patients are at high risk of heart damage from certain treatments. Researchers will follow 600 patients in France for one year, collecting health data to train a machine learning model. The goal is to h…

This study follows up to 5,000 people with Li-Fraumeni syndrome (LFS), a genetic condition that raises the risk for several cancers. Researchers collect medical and family history, blood samples, and questionnaires to better understand cancer patterns, genetic causes, and emotion…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study looks at whether online health education workshops are practical and helpful for teenagers and young adults (ages 15-25) who have cancer. About 48 participants from across France will take part in three digital sessions designed to teach skills for managing daily life …

This study aims to find markers in the immune system that can predict how well a cancer patient responds to radiation therapy. Researchers will analyze blood samples from 40 adults who have already completed radiotherapy without major side effects. The goal is to personalize futu…

This study collects blood, bone marrow, urine, and tissue samples from people with cancer or blood disorders, as well as from their healthy family members who are stem cell donors. The samples are used in lab research to better understand diseases, improve treatments, and find ne…

This study looks at different scoring systems to see which best predicts whether a person will need intensive care after cancer surgery. Researchers will follow 500 adults having cancer surgery and compare the accuracy of these tools. The goal is to help doctors plan better and u…

This study enrolls people with cancer who are already participating in other studies at the National Cancer Institute. Researchers will collect and link medical records and research samples from all of a participant's past, current, and future studies. The goal is to better under…