New antibody therapy targets rare blood cancers in first human trial

NCT ID NCT06150157

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This early-stage study tests a new drug called JNJ-88549968, a bispecific antibody designed to direct the body's immune T cells to attack cancer cells with a specific CALR mutation. The trial will enroll about 220 adults with essential thrombocythemia or myelofibrosis who carry this mutation. The main goals are to check the drug's safety, find the best dose, and see how the body processes it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: JNJ-88549968 (a bispecific antibody that redirects T cells to attack cancer cells), sometimes given with ruxolitinib or momelotinib
What this could lead to: If successful, this could lead to a new targeted treatment option for people with certain rare blood cancers that have not responded to standard therapies.
What could go wrong: This is a very early Phase 1 trial focused on safety and dosing, so it is unknown if the drug will work. Side effects like cytokine release syndrome and other immune reactions are possible risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

essential thrombocythemia myelofibrosis myeloproliferative neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESSENTIAL THROMBOCYTHEMIA MYELOFIBROSIS MYELOPROLIFERATIVE DISORDERS NEOPLASMS

Contacts and locations

Locations

CH LYON SUD - Hematology
RECRUITING

Pierre-Bénite, 69495, France
Carmel Medical Center
RECRUITING

Haifa, 3436212, Israel
Charite Campus Benjamin Franklin
RECRUITING

Berlin, 12203, Germany
Churchill Hospital
RECRUITING

Oxford, OX3 7LE, United Kingdom
City of Hope
RECRUITING

Duarte, California, 91010, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Guy's and St Thomas' Hospital
RECRUITING

London, SE1 9RT, United Kingdom
Hadassah University Hospita Ein Kerem
RECRUITING

Jerusalem, 9112001, Israel
Hopital Saint Louis
RECRUITING

Paris, 75475, France
Hosp. Clinico Univ. de Valencia
RECRUITING

Valencia, 46010, Spain
Hosp. Univ. Germans Trias I Pujol
RECRUITING

Badalona, 08916, Spain
Institut Universitaire du Cancer Toulouse Oncopole
RECRUITING

Toulouse, 31059, France
Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences
RECRUITING

Tianjin, 301617, China
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Juntendo University Hospital
RECRUITING

Bunkyō City, 113 8431, Japan
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Med. Universitatsklinik Essen
RECRUITING

Essen, 45147, Germany
Medizinische Hochschule Hannover
RECRUITING

Hanover, 30625, Germany
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Moffit Cancer center
RECRUITING

Tampa, Florida, 33612, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
National Cancer Center Hospital East
RECRUITING

Kashiwa, 277 8577, Japan
Peking Union Medical College Hospital
RECRUITING

Beijing, 100032, China
Policlinico Sant'Orsola Malpighi
RECRUITING

Bologna, 40138, Italy
Policlinico di Milano
RECRUITING

Milan, 21022, Italy
Princess Margaret Cancer Centre University Health Network
RECRUITING

Toronto, Ontario, M5G 1Z5, Canada
START New Jersey
RECRUITING

East Brunswick, New Jersey, 08816, United States
Sarah Cannon Cancer Institute
RECRUITING

Nashville, Tennessee, 37203, United States
Sheba Medical Center
RECRUITING

Ramat Gan, 5266202, Israel
Start Midwest
RECRUITING

Grand Rapids, Michigan, 49546, United States
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 64239, Israel
UCHealth Cancer Care Anschutz Medical Campus University of Colorado Cancer Center
RECRUITING

Aurora, Colorado, 80045, United States
Universitaetsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Universitaetsklinikum Regensburg
RECRUITING

Regensburg, 93053, Germany
Universitaetsklinikum der RWTH Aachen
RECRUITING

Aachen, 52074, Germany
University College London Hospitals Nhs Foundation Trust
RECRUITING

London, NW1 2PG, United Kingdom
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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