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New pill aims to stop chemo sickness in its tracks

NCT ID NCT07169851

Symptom relief Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 8 times

Summary

This study tests an experimental drug called LY3537021 to see if it can better control nausea and vomiting caused by chemotherapy in adults with cancer. About 204 participants will receive either the drug or a placebo, and researchers will track who has no vomiting and does not need rescue medication. The study lasts about 2 months and focuses on improving comfort during cancer treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 204 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Chemotherapy-naive participants, planned to receive AC or cisplatin-based chemotherapy greater than or equal to (≥)70 milligrams per square meter (mg/m²), on Day 1 of each cycle, with no multiple administrations during the CINV observation period, from Day 2 to Day 5 of each cycle. * Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2. Exclusion Criteria: * Have symptomatic or untreated central nervous system (CNS) metastases. * Have an established diagnosis of uncontrolled diabetes mellitus. * Have a history of, or current evidence of, a clinically significant cardiac condition or QT/QTcF-related conditions. * Have another etiology for nausea and vomiting, or receives medications with know or potential antiemetic activity * Signs, symptoms or history of thyroid tumors * Receives treatment with a gastric inhibitory polypetide (GIP) or glucagon-like peptide-1 (GLP-1) receptor agonist within 4 weeks prior to chemotherapy. * Have participated in a clinical study involving study intervention within 30 days of Cycle 1 Day 1 (C1D1). If the previous study intervention has a long half-life, within 3 months or 5 halflives, whichever is longer, of C1D1. * Are pregnant, breastfeeding, or intend to become pregnant during the study or within 30 days of the last dose of study intervention.

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Conditions

The condition(s) this trial relates to.

cancer Drug-Related Side Effects and Adverse Reactions Nausea neoplasm Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Drug-related side effects and adverse reactions Nausea Neoplasms Vomiting

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    68 sites in 10 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AULSS8 Berica-Ospedale S.Bortolo

    RECRUITING

    Vicenza, 36100, Italy

  • Adana Medical Park Seyhan Hastanesi

    RECRUITING

    Adana, 01140, Turkey (Türkiye)

  • Ankara Bilkent Şehir Hastanesi

    RECRUITING

    Ankara, 06800, Turkey (Türkiye)

  • Antalya Egitim ve Arastırma Hastanesi

    RECRUITING

    Antalya, 07100, Turkey (Türkiye)

  • Aou Ospedali Riuniti Umberto I

    RECRUITING

    Ancona, 60126, Italy

  • Asante Rogue Regional Medical Center

    RECRUITING

    Medford, Oregon, 97504, United States

  • Azienda Ospedaliera Universitaria Pisana

    NOT_YET_RECRUITING

    Pisa, 56126, Italy

  • Azienda Ospedaliero Universitaria

    NOT_YET_RECRUITING

    Modena, 41125, Italy

  • BASS Cancer Center

    RECRUITING

    Walnut Creek, California, 94598, United States

  • BRCR Global - Tamarac

    RECRUITING

    Tamarac, Florida, 33321, United States

  • Ballarat Health Services

    RECRUITING

    Ballarat Central, 3350, Australia

  • Bendigo Health Care Group

    RECRUITING

    Bendigo, 3550, Australia

  • Cancer Care Northwest

    RECRUITING

    Spokane, Washington, 99202, United States

  • Cancer and Blood Specialty Clinic

    RECRUITING

    Los Alamitos, California, 90720, United States

  • Centre Hospitalier d'Annecy

    RECRUITING

    Epagny Metz-Tessy, 74370, France

  • Centrul de Oncologie "Sfântul Nectarie"

    RECRUITING

    Craiova, 200542, Romania

  • Chang Gung Medical Foundation-Linkou Branch

    RECRUITING

    Taoyuan, 333, Taiwan

  • Chi Mei Hospital - Liouying Branch

    RECRUITING

    Tainan, 73657, Taiwan

  • City of Hope Orange County Lennar Foundation Cancer Center

    RECRUITING

    Irvine, California, 92618, United States

  • Clavis Medical

    RECRUITING

    Miami Lakes, Florida, 33014, United States

  • Clinique Victor Hugo Le Mans

    RECRUITING

    Le Mans, 72000, France

  • Community Cancer Trials of Utah

    RECRUITING

    Ogden, Utah, 84405, United States

  • Dicle Üniversitesi

    RECRUITING

    Diyarbakır, 21200, Turkey (Türkiye)

  • E-Da Cancer Hospital

    RECRUITING

    Kaohsiung City, 82445, Taiwan

  • Ege Universitesi Hastanesi

    NOT_YET_RECRUITING

    Bornova, 35100, Turkey (Türkiye)

  • FutureMeds - Madrid

    RECRUITING

    Madrid, 28003, Spain

  • Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi

    RECRUITING

    Gaziantep, 27310, Turkey (Türkiye)

  • Goulburn Valley Health

    RECRUITING

    Shepparton, 3630, Australia

  • Himeji Medical Center

    RECRUITING

    Himeji, 670-8520, Japan

  • Hope and Healing Cancer Services

    RECRUITING

    Hinsdale, Illinois, 60521, United States

  • Hospital General Universitario Gregorio Marañon

    RECRUITING

    Madrid, 28009, Spain

  • Hospital Universitari Sant Joan de Reus

    RECRUITING

    Reus, 43204, Spain

  • Hospital Universitario Fundación Jiménez Díaz

    RECRUITING

    Madrid, 28040, Spain

  • Hospital Universitario Virgen de la Victoria

    RECRUITING

    Málaga, 29010, Spain

  • Hospital de Mataró

    RECRUITING

    Mataró, 08304, Spain

  • Hospital de la Santa Creu i Sant Pau

    RECRUITING

    Barcelona, 08041, Spain

  • Indiana University Melvin and Bren Simon Cancer Center

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Jiangmen Center Hospital

    RECRUITING

    Jiangmen, China

  • John Peter Smith Hospital

    RECRUITING

    Fort Worth, Texas, 76104, United States

  • Kelsey-Seybold Clinic

    NOT_YET_RECRUITING

    Houston, Texas, 77025, United States

  • Kyoto University Hospital

    RECRUITING

    Kyoto, 606-8507, Japan

  • Latrobe Regional Health

    RECRUITING

    Traralgon, 3844, Australia

  • Laura and Isaac Perlmutter Cancer Center

    RECRUITING

    New York, New York, 10016, United States

  • Marin Cancer Care

    RECRUITING

    Greenbrae, California, 94904, United States

  • National Cheng Kung University Hospital

    RECRUITING

    Tainan, 704, Taiwan

  • New York Cancer and Blood Specialists

    NOT_YET_RECRUITING

    Shirley, New York, 11967, United States

  • North Mississippi Hematology and Oncology Associates

    RECRUITING

    Tupelo, Mississippi, 38801, United States

  • Oncology Specialists of Charlotte

    RECRUITING

    Charlotte, North Carolina, 28207, United States

  • Ovidius Clinical Hospital OCH

    RECRUITING

    Ovidiu, 905900, Romania

  • SC Memorial Healthcare International SRL

    RECRUITING

    Bucharest, 013812, Romania

  • Sainte Catherine Institut du Cancer Avignon Provence

    RECRUITING

    Avignon, 84918, France

  • Sakarya Training and Research Hospital

    RECRUITING

    Sakarya, 54100, Turkey (Türkiye)

  • Shizuoka Cancer Center

    RECRUITING

    Nagaizumi-cho,Sunto-gun, 411-8777, Japan

  • Southern Oncology Specialists

    RECRUITING

    Huntersville, North Carolina, 28078, United States

  • Spitalul Clinic Colentina

    RECRUITING

    Bucharest, 020125, Romania

  • Spitalul Clinic Colțea

    RECRUITING

    Bucharest, 030171, Romania

  • Summit Cancer Care, PC

    RECRUITING

    Savannah, Georgia, 31405, United States

  • T.C. Sağlik Bakanliği- Marmara Üniversitesi İstanbul Pendik Eğitim Ve Araştirma Hastanesi

    RECRUITING

    Pendik, 34899, Turkey (Türkiye)

  • Taipei Veterans General Hospital

    RECRUITING

    Taipei, 11217, Taiwan

  • The Cancer Institute Hospital of JFCR

    RECRUITING

    Kōtoku, 135-8550, Japan

  • The First Affiliated Hospital of Henan University of Science &Technology

    RECRUITING

    Luoyang, 471003, China

  • The First People's Hospital of Changde City

    RECRUITING

    Changde, 415003, China

  • Trakya University

    RECRUITING

    Edirne, 22030, Turkey (Türkiye)

  • UCHealth Harmony

    RECRUITING

    Fort Collins, Colorado, 80528, United States

  • WA Country Health Service Trial Centre

    RECRUITING

    Perth, 6102, Australia

  • World Research Link

    RECRUITING

    Baytown, Texas, 77521, United States

  • Zhejiang Provincial People's Hospital

    RECRUITING

    Hangzhou, 310014, China

  • Zhujiang Hospital

    RECRUITING

    Guangzhou, 510280, China

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